26 results about "Glycemic efficacy" patented technology

The invention discloses a marine-derived bioactive peptide with a blood sugar reducing effect, a preparation and application, and belongs to the technical field of bioactive peptides. The amino acid sequence of the bioactive peptide is at least one of FYP, FPF and YAPFPK. Three bioactive peptides with the blood sugar reducing effect are separated and purified from oysters through enzymolysis, ultrafiltration, gel chromatography, liquid chromatography-mass spectrometry and bioinformatics technologies. According to the present invention, chemical synthesis is performed according to the identified peptide fragment sequence, the hypoglycemic activity of the synthesized single peptide fragment and the compounded peptide fragment is detected, and the bioactive peptides have good alpha-glucosidase inhibition activity, such that the bioactive peptides have good application prospects in the preparation of the products with the hypoglycemic effect, and can be widely used in the preparation of the products with the hypoglycemic effect. And a foundation is laid for high value-added utilization of oysters and promotion of research, development and application of functional active peptides.

The invention discloses a cane molasses extract with a blood sugar reducing effect as well as a preparation method and application thereof, and belongs to the field of functional foods. According to the invention, cane molasses is subjected to dissolution, centrifugation, ultrafiltration impurity removal, desalination and nanofiltration concentration, and is mixed with calcium chloride, so that the cane molasses extract with the effect of reducing blood sugar is prepared. Experimental results prove that the cane molasses extract prepared by the invention has the characteristics of low glycemic index (GI), carbohydrate digestive enzyme inhibition, high temperature resistance, long-term storage resistance and the like, can also effectively repair pancreas and liver injury and regulate intestinal flora, and has a comprehensive hypoglycemic effect. The food with low glycemic index is prepared on the basis of the high sucrose carrier for the first time, and the food has sweet taste and the function of reducing blood sugar. The invention provides a new raw material scheme for the preparation of dietary supplement food and hypoglycemic drugs for hyperglycemia people, and has prominent practical application value and wide application prospect.

The application discloses application of Xintong preparation in preparation of a medicine for treating diabetes and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The Xintong preparation is prepared from 13 raw medicinal materials of Huangqi, Gegen, Danshen, Dangshen, Maidong, Heshouwu, Yinyanghuo, Dangui, Zaokesheng, Haizao, Kelp, Muli and Zhishi, has the effects of benefiting qi and activating blood, reducing phlegm and dredging collaterals. Pharmacodynamic experiments show that the Xintong preparation has the effect of reducing blood sugar, can effectively improve the physical conditions of polydipsia, polyphagia, polyuria and emaciation and lack of strength of an animal model of diabetes, significantly reduces the fasting blood sugar and serum insulin level, improves the oral glucose tolerance, has a definite treatment effect on type II diabetes, and expands the clinical application range of the Xintong preparation, and has a wide market application prospect.

The invention discloses a fish-derived active peptide with antioxidant and hypoglycemic effects, a preparation and application, and belongs to the technical field of biological active peptides. The fish-derived active peptide with the effects of resisting oxidation and reducing blood sugar is at least one of peptide fragments with amino acid sequences as shown in SEQ ID NO: 1-SEQ ID NO: 3. According to the invention, three active peptides with antioxidant and hypoglycemic effects are extracted from salmon by-products by adopting protease enzymolysis, LC-MS / MS, a bioinformatics method and other methods, and the active peptides have high DPPH clearance rate, ABTS free radical clearance rate and alpha-glucosidase and alpha-amylase inhibition rate. Therefore, the compound has an important application prospect in the development of products with the effects of resisting oxidation and reducing blood sugar.

The invention discloses a collagen peptide with a blood sugar reducing effect as well as a preparation method and application of the collagen peptide. According to the preparation method provided by the invention, the zymolyte with strong DPP-IV inhibition activity is prepared, and the DPP-IV inhibition rate of the zymolyte under the final concentration of 1mg / mL reaches 69% (the IC50 value is 500mu g / mL); the zymolyte is rich in polypeptide consisting of 4-9 amino acid residues, and the content of the polypeptide accounts for 45%; animal experiments prove that the zymolyte can regulate fasting blood-glucose of mice with type 2 diabetes, improve the oral glucose tolerance and protect the liver. The preparation method provided by the invention is simple in process, enzymolysis controlled release of the target polypeptide is realized, the whole process flow can meet food-grade requirements, and the preparation method can be applied to health-care products and foods related to blood sugar reduction.

The invention belongs to the technical field of fermentation, and particularly relates to medicinal and edible fermentation liquor with a blood sugar reducing effect as well as a preparation method and application of the medicinal and edible fermentation liquor. The fermentation liquor is prepared from the following components in parts by weight: 50 to 75 parts of fructus corni, 45 to 65 parts of stigma croci, 40 to 60 parts of fructus physalis pubescentis, 35 to 50 parts of rumex hanus, 13 to 20 parts of an enzyme preparation and 0.17 to 0.25 part of a leavening agent. The obtained fermentation liquor has the effect of inhibiting alpha-glucosidase through in-vitro verification, the fasting blood glucose level of rats with type 2 diabetes mellitus can be reduced through rat experiment verification, and the effect of reducing blood glucose can be achieved through a PI3K / Akt channel.

This invention provides *Pediococcus lactis* SHI03 and its application in alleviating insulin resistance and type 2 diabetes, belonging to the field of microbial technology. This invention provides *Pediococcus lactis* SHI03, with accession number CCTCC No: M 20242686, and confirms that this strain possesses in vitro α-glucosidase inhibitory activity, exhibiting excellent probiotic and hypoglycemic effects. This invention further provides microbial products containing *Pediococcus lactis* SHI03, including *Pediococcus lactis* SHI03 fermentation broth, *Pediococcus lactis* SHI03 fermentation supernatant, and *Pediococcus lactis* SHI03 cells, and their applications in alleviating high-fat diet-induced insulin resistance and reducing fasting blood glucose in type 2 diabetic mice.

This invention discloses the application of chestnut total burdock ethanol extract in the preparation of hypoglycemic drugs. In this invention, the chestnut total burdock ethanol extract with hypoglycemic effect is obtained by reflux extraction of chestnut total burdock with 70% ethanol. This extract can significantly inhibit the activity of α-glucosidase and has a significant inhibitory effect on postprandial blood glucose levels in T2DM model mice, exhibiting a significant hypoglycemic effect in vivo.

The present application provides a traditional Chinese medicine composition with blood sugar lowering efficacy and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines; the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: birch juice 140-200 parts, jujube fruit 20-40 parts, rehmannia 20-40 parts, adenosma 18-26 parts, periploca 18-26 parts, ophiopogon 18-26 parts, bamboo shavings 12-19 parts, leech 12-19 parts, psyllium 12-19 parts, dogwood 10-14 parts, gordon euryale seed 10-14 parts. In the traditional Chinese medicine composition, the blood sugar lowering effect is mainly achieved by repairing the function of islet beta cells, promoting the regeneration of islet beta cells, improving sugar metabolism, increasing the sensitivity of insulin or improving insulin resistance, so that the overall prescription achieves the effects of invigorating the spleen and lung, nourishing yin and reducing fire, benefiting the stomach and producing saliva, astringing the spleen essence, promoting transportation and transformation, tonifying the kidney and strengthening the body, and relieving polydipsia and restlessness.

The invention provides low-GI coarse cereal and mixed bean brewing powder and a preparation method and application thereof.The preparation method comprises the steps that firstly, tartary buckwheat bran is treated with atmospheric pressure cold plasma, composite cellulose enzymolysis and calcium ion induction gelation are combined, a porous shear thinning gel structure is formed through directional freezing and thawing, and the problem of caking during brewing is solved; secondly, a two-stage fermentation process is adopted, monascus and lactobacillus casei are inoculated in the initial stage, a monascus secretase system is used for breaking cell walls to release sugar, a hypha network is constructed, and embedding of rosa roxburghii tratt pomace polyphenol and synthesis of monacolin K and GABA are synchronously achieved; in the later period, propionibacterium freudenreichii is inoculated to convert lactic acid to generate propionic acid, insulin sensitivity is improved through GABA, and the propionic acid activates GLP-1 to delay gastric emptying, so that the GI value of the product is remarkably reduced. The finally prepared product is fast to brew and disperse and smooth in taste, has the effects of lowering cholesterol and regulating blood sugar, and provides novel healthy food for people with diabetes and metabolic syndromes.

The invention discloses a taste-masked blood sugar-reducing food-medicine homologous homogenized diet and a preparation method thereof, and belongs to the technical field of nutritional products. Comprising the following steps: performing low-temperature ultrasonic elution on food-medicine homologous raw and auxiliary materials with the blood sugar reducing effect by taking water as a solvent, and then filtering; extracting and concentrating to obtain an extract; then adding beta cyclodextrin, and carrying out wet grinding; freeze-drying and crushing the material after the reaction is finished; and mixing with other auxiliary materials to obtain the taste-masked blood sugar-reducing homologous homogenized diet with food and medicine. The traditional Chinese medicine peculiar smell of the homogenized diet with homology of medicine and food can be effectively removed through alkaloid elution and beta-cyclodextrin embedding technologies under a specific process, and a better three-level texture is presented.

The present invention discloses bioactive peptides, preparations and applications thereof with antioxidant and hypoglycemic effects, and belongs to the technical field of bioactive peptides. The bioactive peptide of the present invention is shown as at least one of SEQ ID NO: 1 to SEQ ID NO: 4. The present invention uses defatted Xanthoceras sorbifolia meal as raw material, and after high-temperature heat treatment and ultra-high pressure pretreatment, separates bioactive peptides with antioxidant and hypoglycemic effects by enzymatic hydrolysis, ultrafiltration, liquid chromatography separation technology and combined with bioinformatics technology, and preliminarily identifies its components and sequences by liquid chromatography-mass spectrometry technology. And chemical synthesis is carried out according to the identified peptide sequence to obtain 4 bioactive peptides with antioxidant and hypoglycemic effects. After testing, these peptides and their composite peptides all have good α-glucosidase and α-amylase inhibitory activity, and have good application prospects in the preparation of products with antioxidant and hypoglycemic effects.

The invention discloses an active peptide with antioxidant and hypoglycemic effects, a preparation and application, and belongs to the technical field of bioactive peptides. The amino acid sequence of the active peptide with the antioxidant and hypoglycemic effects is at least one of FDFL, FGSF and WDRFM. According to the preparation method, the small balls are taken as raw materials and are separated and purified to obtain three bioactive peptides with antioxidant and hypoglycemic effects, chemical synthesis is carried out according to the identified peptide fragment sequence, and the antioxidant and hypoglycemic effects of the synthesized single peptide fragment and the compounded peptide fragment are determined. The active peptides have relatively good DPPH (1, 1-diphenyl-2-picrylhydrazyl) clearance rate, alpha-glucosidase inhibition rate and alpha-amylase inhibition rate. Therefore, the active peptides have important application prospects in development of products with the effects of reducing uric acid and resisting oxidation.

The application belongs to the technical field of food additives, and particularly discloses a high-purity Hericium erinaceus and a method for extracting and applying beta-glucan from mycelium of the Hericium erinaceus, which comprises the following steps: pretreating the Hericium erinaceus and the mycelium thereof, extracting with hot water, alcohol precipitation, and removing protein by Seavg method to obtain high-purity beta-glucan. The method for extracting provided by the application improves the utilization of polysaccharides in the Hericium erinaceus and the mycelium thereof, and the content of beta-glucan in the polysaccharides obtained from the Hericium erinaceus and the mycelium thereof is greater than 80%. It is proved by the example of making grain bread that the high-purity beta-glucan can significantly improve the water retention and oxidation resistance of grain products, not only improves the quality characteristics of biscuits, but also has certain antioxidant and hypoglycemic effects.

The application discloses application of Akkermansia muciniphila in preparation of a hypoglycemic product. Experiments prove that the Akkermansia muciniphila is Akkermansia muciniphila AkkTimepie001 with a preservation number of CCTCC NO: M 20231906, can effectively increase the body weight of a type 2 diabetes model mouse, improve the glucose tolerance capacity of the type 2 diabetes model mouse, and reduce the fasting blood glucose level, and confirms that the Akkermansia muciniphila has a significant blood glucose lowering effect.

The invention discloses euphausia superba active peptide with effects of dispelling effects of alcohol and reducing blood sugar, a preparation and application, and belongs to the technical field of biological active peptide. The amino acid sequence of the euphausia superba active peptide with the effects of dispelling the effects of alcohol and reducing blood sugar is at least one of FPFP, FPF and FPW. According to the invention, protease enzymolysis, LC-MS / MS, a bioinformatics method and other methods are adopted to extract and obtain three active peptides with effects of dispelling the effects of alcohol and reducing blood sugar from Antarctic krill, and single peptide fragments and compound combinations of the active peptides have high alpha-glucosidase inhibition rate, alpha-amylase inhibition rate and ADH activation rate. Therefore, the active peptide not only can be used as a natural hangover alleviating agent in food and medicines, but also can be used as a natural hypoglycemic agent in medicines; the method has an important application prospect in the development of products with the effects of dispelling the effects of alcohol and reducing blood sugar.

The present application relates to the technical fields of active ingredient extraction and application, and discloses a preparation method of a blood sugar reducing traditional Chinese medicine preparation, comprising the following steps: filtering and centrifugally separating papaya milk obtained by cutting a papaya from a Chinese quince, collecting the upper liquid to obtain pretreated papaya milk; passing the pretreated papaya milk through an ultrafiltration membrane system with a molecular weight of 40000-55000 Dal, and collecting the milk permeating through the ultrafiltration membrane; passing the milk through an ultrafiltration membrane system with a molecular weight of 15000-30000 Dal, and collecting the milk intercepted by the ultrafiltration membrane; performing multi-stage freeze drying on the ultrafiltration membrane milk to obtain milk powder, and then preparing the milk powder into capsules, tablets or granules to obtain the blood sugar reducing traditional Chinese medicine preparation. The present application uses papaya milk as raw material to prepare milk powder with high blood sugar reducing activity through filtering, centrifuging and two-stage ultrafiltration membrane treatment, and the quality of the milk powder is high. The milk powder is used for preparing the blood sugar reducing traditional Chinese medicine preparation, and can improve the blood sugar reducing efficacy of the traditional Chinese medicine preparation.

The invention discloses a bifunctional active peptide having both ACE and DPP‑IV inhibitory activity and its preparation method and application, and belongs to the field of active peptide biotechnology. The present invention prepares and identifies a bifunctional new active peptide having both ACE and DPP‑IV inhibitory activity from sea cucumber hydrolysate, not only can suppress the activity of ACE, but also has DPP‑IV inhibitory activity, and its bifunctionality makes it have the application value in preparing blood pressure lowering and hypoglycemic efficacy products. The active peptide involved in the present invention, can significantly suppress the activity of ACE, while possessing DPP‑IV inhibitory activity, with the characteristics of simple structure, safety, strong activity, the effect of nutrition and health care can be played, it is expected to provide effective active ingredients for developing food and hypotensive, hypoglycemic or hypotensive and hypoglycemic efficacy products without side effects, with a wide range of applications.

The invention discloses a low-GI polygonatum sibiricum rice cake and a preparation method thereof, and belongs to the technical field of food processing, and the low-GI polygonatum sibiricum rice cake comprises the following raw materials in parts by weight: 100 parts of water-milled polished round-grained rice flour, 30-40 parts of cooked soybean powder, 15-20 parts of starch acetate, 5-10 parts of xanthan gum, 5-15 parts of polygonatum sibiricum powder and 30-70 parts of water. The preparation method comprises the following steps of mixing the raw materials, performing high-pressure steaming, performing extrusion, and performing water-cooling forming so as to obtain the low-GI rhizoma polygonati rice cake. The rice cake can provide enough energy and nutrition, and the traditional Chinese medicinal material polygonatum kingianum which has the effect of reducing blood sugar is added, so that the taste of the traditional rice cake is enriched. Moreover, the method disclosed by the invention is short in production period, relatively low in cost, simple in process and suitable for industrial flow line production.

The invention provides a composition containing medicinal and edible astragalus polysaccharide and application of the composition in reducing blood sugar. The composition provided by the invention consists of astragalus polysaccharide, tremella polysaccharide, lycium barbarum polysaccharide and angelica polysaccharide. The mass ratio of the raw materials is (1-3): (1-3): (1-3): (1-3). The hypoglycemic effect of the plant polysaccharide and the composition thereof is proved through a hyperglycemia mouse model, it is shown that the four plant polysaccharides can reduce the blood sugar of mice, after the four plant polysaccharides are compounded, the obvious synergistic interaction effect is shown, and the effect is obviously better than that of other schemes that every two plant polysaccharides are combined or combined in a stacked mode. Clinical medical manifestations of polydipsia, polyphagia, diuresis and weight loss of diabetes mellitus are slowed down and improved after polysaccharide combination treatment, a positive effect on reduction of hyperglycemia is achieved, the adopted plant polysaccharide is safe and non-toxic, blood sugar can be effectively reduced, and the diabetes mellitus health-care product has a good health-care effect on diabetes mellitus. The traditional Chinese medicine composition can also prevent acute complications caused by hyperglycemia, such as diabetic ketoacidosis, hyperglycemia syndrome and the like.

The invention discloses a protein peptide with ACE (Angiotensin Converting Enzyme) and DPP-IV (Dipeptidyl Peptidase-IV) inhibitory activity and a screening method thereof, and belongs to the technical field of food-borne bioactive peptide development. The difunctional peptide with ACE and DPP-IV inhibitory activity is identified from potato protein for the first time, the amino acid sequence of the difunctional peptide is LRWI, FGPK, FNL, IPF, TYF or VPFY, the difunctional peptide plays a role in relieving hypertension and type 2 diabetes at the same time, and the difunctional peptide has application value in preparation of products with the efficacy of reducing blood pressure and blood sugar due to the difunctionality of the difunctional peptide.

The invention relates to the technical field of dietary therapy sugar control or sugar reduction, in particular to natural camellia oil with a blood sugar reducing effect, and provides application of the camellia oil in preparation of drugs, functional foods or health care products for reducing blood sugar. The camellia oil is taken as a research object, and the research finds that the camellia oil can effectively reduce the fasting blood-glucose level of diabetic mice and relieve polydipsia and polyphagia symptoms, can be used for preventing or treating the type 2 diabetes and provides an important scientific basis for diet intervention prevention and treatment of the type 2 diabetes.

The invention discloses a spirulina hypoglycemic composite solid beverage and a preparation method thereof, and belongs to the technical field of functional foods. The solid beverage comprises the following raw materials in parts by weight: 1-4 parts of kiwi fruits, 1-4 parts of dendrobium officinale, 0.5-1.5 parts of Chinese wolfberry fruits, 4-6 parts of spirulina and 0.1-0.3 part of beta-cyclodextrin. The preparation method specifically comprises the following steps: (1) weighing the raw materials; (2) cleaning kiwi fruits, dendrobium officinale and Chinese wolfberry fruits, crushing and homogenizing to obtain mixed slurry; and (3) uniformly mixing spirulina, beta-cyclodextrin and the slurry, and performing vacuum freeze drying to obtain the spirulina freeze-dried powder. The obtained solid beverage is rich in nutrient substances, free of fishy smell, capable of presenting fruit fragrance, harmonious in taste, high in antioxidant activity, high in inhibitory activity on alpha-amylase and alpha-glucosidase, remarkable in blood sugar reducing effect, suitable for wider consumer groups and wide in market prospect.

The application discloses a hypoglycemic composition containing Hippophae rhamnoides L. protein peptides and application thereof, and belongs to the field of compositions. The hypoglycemic composition containing Hippophae rhamnoides L. protein peptides comprises mulberry leaf extract and Hippophae rhamnoides L. protein peptides, and the mass ratio of the two is (1:5) to (5:1). The composition is prepared by combining the mulberry leaf extract and the Hippophae rhamnoides L. protein peptides in a specific ratio, so that the synergistic effect of the two can be achieved, and good blood glucose lowering effect can be achieved in a short time, and the effect is better than that of similar natural ingredient blood glucose lowering products.

The invention discloses preparation of amomum tsao-ko flower tea and application of active ingredients of the amomum tsao-ko flower tea in blood sugar reduction. The amomum tsao-ko flower tea with a potential blood sugar resisting effect is prepared by taking amomum tsao-ko flowers as a raw material through specific withering and drying steps. Three natural components capable of inhibiting the activity of alpha-glucosidase are further separated and extracted from tsaoko amomum flowers, are all diphenyl heptane compounds through identification, and can be used for reducing the peak value of postprandial blood sugar concentration so as to achieve the purpose of controlling blood sugar. Therefore, the compounds can be used for developing medicines or functional products with a hypoglycemic effect.

Provided are a Bacillus coagulans strain VHProbi C08 having a blood glucose reduction efficacy and an application thereof in preparation of a hypoglycemic product. The accession number of the strain is CCTCCM 2019738. Further provided is a hypoglycemic product comprising the Bacillus coagulans VHProbi C08 and / or the fermentation product of Bacillus coagulans VHProbi C08. A carbon source used in the culture medium of the strain is any one or more of fructooligosaccharide, galactooligosaccharides, and inulin.