15 results about "Glycemic efficacy" patented technology

The application discloses application of Xintong preparation in preparation of a medicine for treating diabetes and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The Xintong preparation is prepared from 13 raw medicinal materials of Huangqi, Gegen, Danshen, Dangshen, Maidong, Heshouwu, Yinyanghuo, Dangui, Zaokesheng, Haizao, Kelp, Muli and Zhishi, has the effects of benefiting qi and activating blood, reducing phlegm and dredging collaterals. Pharmacodynamic experiments show that the Xintong preparation has the effect of reducing blood sugar, can effectively improve the physical conditions of polydipsia, polyphagia, polyuria and emaciation and lack of strength of an animal model of diabetes, significantly reduces the fasting blood sugar and serum insulin level, improves the oral glucose tolerance, has a definite treatment effect on type II diabetes, and expands the clinical application range of the Xintong preparation, and has a wide market application prospect.

The invention discloses a fish-derived active peptide with antioxidant and hypoglycemic effects, a preparation and application, and belongs to the technical field of biological active peptides. The fish-derived active peptide with the effects of resisting oxidation and reducing blood sugar is at least one of peptide fragments with amino acid sequences as shown in SEQ ID NO: 1-SEQ ID NO: 3. According to the invention, three active peptides with antioxidant and hypoglycemic effects are extracted from salmon by-products by adopting protease enzymolysis, LC-MS / MS, a bioinformatics method and other methods, and the active peptides have high DPPH clearance rate, ABTS free radical clearance rate and alpha-glucosidase and alpha-amylase inhibition rate. Therefore, the compound has an important application prospect in the development of products with the effects of resisting oxidation and reducing blood sugar.

This invention provides *Pediococcus lactis* SHI03 and its application in alleviating insulin resistance and type 2 diabetes, belonging to the field of microbial technology. This invention provides *Pediococcus lactis* SHI03, with accession number CCTCC No: M 20242686, and confirms that this strain possesses in vitro α-glucosidase inhibitory activity, exhibiting excellent probiotic and hypoglycemic effects. This invention further provides microbial products containing *Pediococcus lactis* SHI03, including *Pediococcus lactis* SHI03 fermentation broth, *Pediococcus lactis* SHI03 fermentation supernatant, and *Pediococcus lactis* SHI03 cells, and their applications in alleviating high-fat diet-induced insulin resistance and reducing fasting blood glucose in type 2 diabetic mice.

This invention discloses the application of chestnut total burdock ethanol extract in the preparation of hypoglycemic drugs. In this invention, the chestnut total burdock ethanol extract with hypoglycemic effect is obtained by reflux extraction of chestnut total burdock with 70% ethanol. This extract can significantly inhibit the activity of α-glucosidase and has a significant inhibitory effect on postprandial blood glucose levels in T2DM model mice, exhibiting a significant hypoglycemic effect in vivo.

The present application provides a traditional Chinese medicine composition with blood sugar lowering efficacy and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines; the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: birch juice 140-200 parts, jujube fruit 20-40 parts, rehmannia 20-40 parts, adenosma 18-26 parts, periploca 18-26 parts, ophiopogon 18-26 parts, bamboo shavings 12-19 parts, leech 12-19 parts, psyllium 12-19 parts, dogwood 10-14 parts, gordon euryale seed 10-14 parts. In the traditional Chinese medicine composition, the blood sugar lowering effect is mainly achieved by repairing the function of islet beta cells, promoting the regeneration of islet beta cells, improving sugar metabolism, increasing the sensitivity of insulin or improving insulin resistance, so that the overall prescription achieves the effects of invigorating the spleen and lung, nourishing yin and reducing fire, benefiting the stomach and producing saliva, astringing the spleen essence, promoting transportation and transformation, tonifying the kidney and strengthening the body, and relieving polydipsia and restlessness.

The invention discloses an active peptide with antioxidant and hypoglycemic effects, a preparation and application, and belongs to the technical field of bioactive peptides. The amino acid sequence of the active peptide with the antioxidant and hypoglycemic effects is at least one of FDFL, FGSF and WDRFM. According to the preparation method, the small balls are taken as raw materials and are separated and purified to obtain three bioactive peptides with antioxidant and hypoglycemic effects, chemical synthesis is carried out according to the identified peptide fragment sequence, and the antioxidant and hypoglycemic effects of the synthesized single peptide fragment and the compounded peptide fragment are determined. The active peptides have relatively good DPPH (1, 1-diphenyl-2-picrylhydrazyl) clearance rate, alpha-glucosidase inhibition rate and alpha-amylase inhibition rate. Therefore, the active peptides have important application prospects in development of products with the effects of reducing uric acid and resisting oxidation.

The application belongs to the technical field of food additives, and particularly discloses a high-purity Hericium erinaceus and a method for extracting and applying beta-glucan from mycelium of the Hericium erinaceus, which comprises the following steps: pretreating the Hericium erinaceus and the mycelium thereof, extracting with hot water, alcohol precipitation, and removing protein by Seavg method to obtain high-purity beta-glucan. The method for extracting provided by the application improves the utilization of polysaccharides in the Hericium erinaceus and the mycelium thereof, and the content of beta-glucan in the polysaccharides obtained from the Hericium erinaceus and the mycelium thereof is greater than 80%. It is proved by the example of making grain bread that the high-purity beta-glucan can significantly improve the water retention and oxidation resistance of grain products, not only improves the quality characteristics of biscuits, but also has certain antioxidant and hypoglycemic effects.

The application discloses application of Akkermansia muciniphila in preparation of a hypoglycemic product. Experiments prove that the Akkermansia muciniphila is Akkermansia muciniphila AkkTimepie001 with a preservation number of CCTCC NO: M 20231906, can effectively increase the body weight of a type 2 diabetes model mouse, improve the glucose tolerance capacity of the type 2 diabetes model mouse, and reduce the fasting blood glucose level, and confirms that the Akkermansia muciniphila has a significant blood glucose lowering effect.

The invention discloses euphausia superba active peptide with effects of dispelling effects of alcohol and reducing blood sugar, a preparation and application, and belongs to the technical field of biological active peptide. The amino acid sequence of the euphausia superba active peptide with the effects of dispelling the effects of alcohol and reducing blood sugar is at least one of FPFP, FPF and FPW. According to the invention, protease enzymolysis, LC-MS / MS, a bioinformatics method and other methods are adopted to extract and obtain three active peptides with effects of dispelling the effects of alcohol and reducing blood sugar from Antarctic krill, and single peptide fragments and compound combinations of the active peptides have high alpha-glucosidase inhibition rate, alpha-amylase inhibition rate and ADH activation rate. Therefore, the active peptide not only can be used as a natural hangover alleviating agent in food and medicines, but also can be used as a natural hypoglycemic agent in medicines; the method has an important application prospect in the development of products with the effects of dispelling the effects of alcohol and reducing blood sugar.

The invention discloses a low-GI polygonatum sibiricum rice cake and a preparation method thereof, and belongs to the technical field of food processing, and the low-GI polygonatum sibiricum rice cake comprises the following raw materials in parts by weight: 100 parts of water-milled polished round-grained rice flour, 30-40 parts of cooked soybean powder, 15-20 parts of starch acetate, 5-10 parts of xanthan gum, 5-15 parts of polygonatum sibiricum powder and 30-70 parts of water. The preparation method comprises the following steps of mixing the raw materials, performing high-pressure steaming, performing extrusion, and performing water-cooling forming so as to obtain the low-GI rhizoma polygonati rice cake. The rice cake can provide enough energy and nutrition, and the traditional Chinese medicinal material polygonatum kingianum which has the effect of reducing blood sugar is added, so that the taste of the traditional rice cake is enriched. Moreover, the method disclosed by the invention is short in production period, relatively low in cost, simple in process and suitable for industrial flow line production.

The invention provides a composition containing medicinal and edible astragalus polysaccharide and application of the composition in reducing blood sugar. The composition provided by the invention consists of astragalus polysaccharide, tremella polysaccharide, lycium barbarum polysaccharide and angelica polysaccharide. The mass ratio of the raw materials is (1-3): (1-3): (1-3): (1-3). The hypoglycemic effect of the plant polysaccharide and the composition thereof is proved through a hyperglycemia mouse model, it is shown that the four plant polysaccharides can reduce the blood sugar of mice, after the four plant polysaccharides are compounded, the obvious synergistic interaction effect is shown, and the effect is obviously better than that of other schemes that every two plant polysaccharides are combined or combined in a stacked mode. Clinical medical manifestations of polydipsia, polyphagia, diuresis and weight loss of diabetes mellitus are slowed down and improved after polysaccharide combination treatment, a positive effect on reduction of hyperglycemia is achieved, the adopted plant polysaccharide is safe and non-toxic, blood sugar can be effectively reduced, and the diabetes mellitus health-care product has a good health-care effect on diabetes mellitus. The traditional Chinese medicine composition can also prevent acute complications caused by hyperglycemia, such as diabetic ketoacidosis, hyperglycemia syndrome and the like.

The invention relates to the technical field of dietary therapy sugar control or sugar reduction, in particular to natural camellia oil with a blood sugar reducing effect, and provides application of the camellia oil in preparation of drugs, functional foods or health care products for reducing blood sugar. The camellia oil is taken as a research object, and the research finds that the camellia oil can effectively reduce the fasting blood-glucose level of diabetic mice and relieve polydipsia and polyphagia symptoms, can be used for preventing or treating the type 2 diabetes and provides an important scientific basis for diet intervention prevention and treatment of the type 2 diabetes.

The invention discloses a spirulina hypoglycemic composite solid beverage and a preparation method thereof, and belongs to the technical field of functional foods. The solid beverage comprises the following raw materials in parts by weight: 1-4 parts of kiwi fruits, 1-4 parts of dendrobium officinale, 0.5-1.5 parts of Chinese wolfberry fruits, 4-6 parts of spirulina and 0.1-0.3 part of beta-cyclodextrin. The preparation method specifically comprises the following steps: (1) weighing the raw materials; (2) cleaning kiwi fruits, dendrobium officinale and Chinese wolfberry fruits, crushing and homogenizing to obtain mixed slurry; and (3) uniformly mixing spirulina, beta-cyclodextrin and the slurry, and performing vacuum freeze drying to obtain the spirulina freeze-dried powder. The obtained solid beverage is rich in nutrient substances, free of fishy smell, capable of presenting fruit fragrance, harmonious in taste, high in antioxidant activity, high in inhibitory activity on alpha-amylase and alpha-glucosidase, remarkable in blood sugar reducing effect, suitable for wider consumer groups and wide in market prospect.

The application discloses a hypoglycemic composition containing Hippophae rhamnoides L. protein peptides and application thereof, and belongs to the field of compositions. The hypoglycemic composition containing Hippophae rhamnoides L. protein peptides comprises mulberry leaf extract and Hippophae rhamnoides L. protein peptides, and the mass ratio of the two is (1:5) to (5:1). The composition is prepared by combining the mulberry leaf extract and the Hippophae rhamnoides L. protein peptides in a specific ratio, so that the synergistic effect of the two can be achieved, and good blood glucose lowering effect can be achieved in a short time, and the effect is better than that of similar natural ingredient blood glucose lowering products.

Provided are a Bacillus coagulans strain VHProbi C08 having a blood glucose reduction efficacy and an application thereof in preparation of a hypoglycemic product. The accession number of the strain is CCTCCM 2019738. Further provided is a hypoglycemic product comprising the Bacillus coagulans VHProbi C08 and / or the fermentation product of Bacillus coagulans VHProbi C08. A carbon source used in the culture medium of the strain is any one or more of fructooligosaccharide, galactooligosaccharides, and inulin.