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Antitumor compounds derived from G. nujiangnsis, and preparation method and application thereof

A compound, anti-tumor technology, applied in the field of natural compounds

Inactive Publication Date: 2014-11-05
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Nujiang Garcinia (G.nujiangensis) is a unique plant in my country. It is distributed in the northwest of Yunnan Province and Tibet. It grows in areas with an altitude of 800 meters to 1,700 meters. Related reports on the preparation of antitumor active substances from Huang Zhong

Method used

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  • Antitumor compounds derived from G. nujiangnsis, and preparation method and application thereof
  • Antitumor compounds derived from G. nujiangnsis, and preparation method and application thereof
  • Antitumor compounds derived from G. nujiangnsis, and preparation method and application thereof

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Embodiment

[0018] 1. Preparation of anti-tumor compounds

[0019] a) The Nujiang Garcinia (collected from Nujiang Prefecture, Yunnan Province in August 2010, the plant sample was identified by Professor Zhou Yuanchuan of Yunnan College of Traditional Chinese Medicine, and the sample was kept in the Chinese Medicine Innovation Laboratory of Shanghai University of Traditional Chinese Medicine, marked as GN0001) and extracted with acetone , The volume of acetone used for each soaking is 5 times the mass of Garcinia Nujiangensis to be extracted. Each soaking for one week, a total of 3 soaking extractions; the acetone soaking extracts are combined and concentrated under reduced pressure until there is no acetone smell; The concentrated solution was extracted with dichloromethane 4 times, and the dichloromethane extract was concentrated under reduced pressure to obtain the extract;

[0020] b) The obtained extract is separated by silica gel column chromatography: gradient elution is carried out wit...

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Abstract

The invention discloses two antitumor compounds derived from G. nujiangnsis, and a preparation method and an application thereof. The antitumor compounds are obtained by extracting from G. nujiangnsis, and have the following chemical structural formulas represented by formula A and formula B. Pharmacological tests prove that, the antitumor compounds both have significant antitumor activity, especially, the compound represented by the formula A has a significant inhibiting activity on brain glioma, pancreatic cancer, lung cancer, gastric cancer, melanoma, breast cancer and liver cancer; the compound represented by the formula B has significant inhibiting activity on brain glioma, pancreatic cancer, gastric cancer, melanoma, breast cancer and liver cancer; the compound represented by the formula A or / and the compound represented by the formula B are expected to be used as active ingredients to be used in preparing antitumor medicine preparations, and have medicinal prospects.

Description

Technical field [0001] The invention relates to an antitumor compound and a preparation method and application thereof, in particular to two antitumor compounds derived from Nujiang Garcinia and a preparation method and application thereof, belonging to the technical field of natural compounds. Background technique [0002] The structure of natural products has novel and diverse characteristics. Active natural products with novel structures are one of the important sources of lead compounds. Their discovery will not only promote the progress of chemistry and pharmaceutical research, but may also lead to the discovery of new drug targets. More than 60% of the currently used anti-tumor drugs are directly or indirectly derived from natural products, such as the anti-tumor drugs paclitaxel and vinca alkaloids. Searching for lead compounds with anti-tumor activity from traditional Chinese medicines and medicinal plants, studying its mechanism of action, and developing anti-tumor ther...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/78A61P35/00
Inventor 徐宏喜夏正祥章丹丹劳远至谭红胜刘珍艳
Owner SHANGHAI UNIV OF T C M