Composition for preventing and treating fatty liver and preparation method thereof

A composition and fatty liver technology, applied in the field of chemistry, can solve less obvious problems, achieve the effects of alleviating liver damage, improving memory and spirit, and improving blood lipid metabolism

Active Publication Date: 2013-12-11
江苏赛谷细胞工程研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing methods generally prevent fatty liver by changing living habits and dietary structure, but the effect varies from person to person and is not obvious; fatty liver is treated by adjusting diet, increasing exercise, and combining drugs. Drugs are often used to protect liver cells, remove fat Drugs and antioxidants, such as vitamin B, C, E, lecithin, ursodeoxycholic acid, silymarin, inosine, coenzyme A, reduced glutathione, taurine, carnitine orotate, Liver Tylenol, and certain lipid-lowering drugs, etc.
Although there are many above-mentioned drugs, most of them still need further verification of their efficacy and safety. Therefore, they must be selected correctly under the guidance of a doctor and must not be abused.

Method used

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  • Composition for preventing and treating fatty liver and preparation method thereof
  • Composition for preventing and treating fatty liver and preparation method thereof
  • Composition for preventing and treating fatty liver and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019]

[0020] Preparation method: Use vinegar as a solvent and add various raw materials to prepare a 100ml solution.

[0021] Animal experiment

[0022] Eighteen healthy 4-week-old male mice with C57BL / B6 background were randomly and double-blindly divided into three groups, the control group, the prevention group, and the treatment group, each with 6 mice. The control group was given a 60% high-fat diet for four weeks; the prevention group was given the formula of Example 1 while the high-fat diet was given, once a day, 200ul each time, for four consecutive weeks; the treatment group, the mice were given a high-fat diet for four weeks Example 1 Gavage once a day, 200ul each time, for 7 days. The control group was given the same amount of saline by gavage. Mice eat and drink freely during the experiment, fasting overnight at the end of the day can not help but water. The blood was taken from the abdominal aorta after intraperitoneal injection of 3% sodium pentobarbital anesth...

Embodiment 2

[0035]

[0036] The preparation method and the treatment effect are similar to those in Example 1, which can obviously inhibit the progress of fatty liver.

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PUM

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Abstract

The invention relates to a composition and a preparation method thereof, and particularly relates to a composition for preventing and treating fatty liver and a preparation method thereof, belonging to the field of a chemical technology. The composition comprises ginkgo biloba extractive, allicin, vitamin C, vitamin B12 and vinegar, thus being capable of relieving lipid oxidation damage of the liver, enhancing the oxidation resistance of the liver, inhibiting the activity of Kupffer cells, lowering the inflammatory reaction, protecting the liver, reducing serum free fatty acid (FFA), reducing accumulation of liver fat, and preventing the fatty liver.

Description

Technical field [0001] The invention relates to a composition and a preparation method, in particular to a composition for the prevention and treatment of liver disease and a preparation method, and belongs to the technical field of chemistry. Background technique [0002] Fatty liver is a clinical syndrome characterized by hepatocyte steatosis and fat accumulation, the main body of the disease is in the liver lobules, and there is no history of excessive drinking. It has become a serious threat to human health worldwide. Similarly, with the improvement of living standards and changes in lifestyle and diet in my country, the incidence of fatty liver is getting higher and higher, and the age of onset tends to be younger. The pathogenesis is not yet fully understood. Oxygen stress and lipid peroxidation, insulin resistance, iron overload, cytokine action, immune response, genes and other related factors are involved in the pathogenesis. Existing methods generally prevent fatty li...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/16A61P1/16A61K31/375A61K31/714A61K31/519A61K31/255
Inventor吕凌杨豪俊刘晓珊
Owner江苏赛谷细胞工程研究院有限公司