Application of epigallocatechin gallate stearates and medicinal composition for treating psoriasis

Abstract

The invention discloses application of epigallocatechin gallate stearates and a medicinal composition for treating psoriasis and belongs to the technical field of theepigallocatechin gallate stearates. The epigallocatechin gallate stearates and the medicinal composition comprising the epigallocatechin gallate stearates can be used for treating psoriasis.

Description

technical field [0001] The invention belongs to the technical field of epigallocatechin gallate stearate, and in particular relates to the application of epigallocatechin gallate stearate and a pharmaceutical composition for treating psoriasis. Background technique [0002] Psoriasis (Psoriasis), commonly known as psoriasis, is an immune abnormal chronic inflammatory proliferative skin disease determined by polygenic inheritance and stimulated by multiple environmental factors; the main pathological change of psoriasis is epidermal keratinocyte hyperplasia Excessive and abnormal differentiation, parakeratosis, lack of granular layer, skin neovascularization and inflammatory cell infiltration, etc. Its clinical manifestation is mainly that the skin of the affected area repeatedly produces multiple layers of silvery white dry scales, and there are extensive infiltrating erythema and obvious bleeding points under the scales. Most patients have pruritus symptoms. [0003] The e...

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Problems solved by technology

[0004] At present, the drug treatment of psoriasis includes systemic and local treatment of chemical drugs, traditional Chinese medicines, biological agents and their combined application; Cyclosporine, etanercept, dexamethasone and other glucocorticoids all have shortcomings: most of the therapeutic effects can only achieve short-term clinical curative effect, and cannot effectively prolong the remission period of patients, making it difficult to control recurrence and even more difficult to cure the disease; Most drugs have adverse reactions of varying degrees, which are difficult for patients to tolerate [see "Inner Mongolia Medical Journal" 2012,44(6):707-719 "Progress in the Treatment of Psoriasis"]; and some drugs are expensive; from the perspective of safety consideration, topical over systemic therapy

The literature has reported the effective therapeutic effect of tea polyphenols on animal models of psoriasis [see "Experimental Dermatology" 2007;16:678–684. "Green tea polyphenol induces caspase14in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model”], the disadvantage is that tea polyphenols are easily oxidized, resulting in poor stability and poor fat solubility, resulting in weak membrane penetration ability, which brings difficulties to its wide application

[0006] Fat-soluble tea polyphenols are high-level fatty acid esters of tea polyphenols developed by researchers in order to overcome the above-mentioned shortcomings of tea polyphenols through chemical modification. Epigallocatechin Gallate Stearates (EGCGS) is a product of fat-soluble tea polyphenols, based on its excellent safety and antioxidant properties , At present, the epigallocatechin gallate stearate circulating on the market is mainly used as an antioxidant for edible oils and foods, and there is no application of epigallocatechin gallate stearate to treat psoriasis disease report

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