Application of epigallocatechin gallate stearates and medicinal composition for treating psoriasis

A technology of epigallocatechin and gallate, which can be used in drug combinations, medical preparations containing active ingredients, skin diseases, etc. It can solve the problems of patients' intolerance, inability to effectively prolong the remission period of patients, and difficulties in wide application, etc. problems, to achieve the effect of improving or disappearing pathological state and symptoms, good development and application prospects, and avoiding adverse reactions

Inactive Publication Date: 2013-12-25
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drug treatment of psoriasis includes systemic and local treatment of chemical drugs, traditional Chinese medicines, biological agents and their combined application; Cyclosporine, etanercept, dexamethasone and other glucocorticoids all have shortcomings: most of the therapeutic effects can only achieve short-term clinical curative effect, and cannot effectively prolong the remission period of patients, making it difficult to control recurrence and even more difficult to cure the disease; Most drugs have adverse reactions of varying degrees, which are difficult for patients to tolerate [see "Inner Mongolia Medical Journal" 2012,44(6):707-719 "Progress in the Treatment of Psoriasis"]; and some drugs are expensive; from the perspective of safety consideration, topical over systemic therapy
The literature has reported the effective therapeutic effect of tea polyphenols on animal models of psoriasis [see "Experimental Dermatology" 2007;16:678–684. "Green tea polyphenol induces caspase14in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model”], the disadvantage is that tea polyphenols are easily oxidized, resulting in poor stability and poor fat solubility, resulting in weak membrane penetration ability, which brings difficulties to its wide application
[0006] Fat-soluble tea polyphenols are high-level fatty acid esters of tea polyphenols developed by researchers in order to overcome the above-mentioned shortcomings of tea polyphenols through chemical modification. Epigallocatechin Gallate Stearates (EGCGS) is a product of fat-soluble tea polyphenols, based on its excellent safety and antioxidant properties , At present, the epigallocatechin gallate stearate circulating on the market is mainly used as an antioxidant for edible oils and foods, and there is no application of epigallocatechin gallate stearate to treat psoriasis disease report

Method used

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  • Application of epigallocatechin gallate stearates and medicinal composition for treating psoriasis
  • Application of epigallocatechin gallate stearates and medicinal composition for treating psoriasis
  • Application of epigallocatechin gallate stearates and medicinal composition for treating psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 0.2% Epigallocatechin Gallate Stearate Gel

[0023] Prescription Composition:

[0024]

[0025] Preparation:

[0026] Accurately weigh each component according to the prescription amount; take Carbomer 934P and sprinkle it on the surface of purified water that has been boiled and cooled, and swell overnight to obtain a transparent gel matrix. Slowly add triethanolamine under stirring to make the pH value of the matrix 7, and set aside; Dissolve epigallocatechin gallate stearate and ethylparaben in absolute ethanol; transfer the above solution to a spare gel matrix, mix well, stir in a water bath at 80°C for 1 hour, add propylene glycol, Glycerin, laurocaprazine, mix evenly, add purified water to 1000.0g, stir evenly, and obtain.

Embodiment 2

[0028] 1% Epigallocatechin Gallate Stearate Gel

[0029] Prescription Composition:

[0030]

[0031] Preparation:

[0032] Accurately weigh each component according to the prescription amount; take Carbomer 934P and sprinkle it on the surface of purified water that has been boiled and cooled, and swell overnight to obtain a transparent gel matrix. Slowly add triethanolamine under stirring to make the pH value of the matrix 7, and set aside; Dissolve epigallocatechin gallate stearate and ethylparaben in absolute ethanol; transfer the above solution to a spare gel matrix, mix well, stir in a water bath at 80°C for 1 hour, add propylene glycol, Glycerin, laurocaprazine, mix evenly, add purified water to 1000.0g, stir evenly, and obtain.

Embodiment 3

[0034] 5% Epigallocatechin Gallate Stearate Gel

[0035] Prescription Composition:

[0036]

[0037]

[0038] Preparation:

[0039] Accurately weigh each component according to the prescription amount; take Carbomer 934P and sprinkle it on the surface of purified water that has been boiled and cooled, and swell overnight to obtain a transparent gel matrix. Slowly add triethanolamine under stirring to make the pH value of the matrix 7, and set aside; Dissolve epigallocatechin gallate stearate and ethylparaben in absolute ethanol; transfer the above solution to a spare gel matrix, mix well, stir in a water bath at 80°C for 1 hour, add propylene glycol, Glycerin, laurocaprazine, mix evenly, add purified water to 1000.0g, stir evenly, and obtain.

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PUM

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Abstract

The invention discloses application of epigallocatechin gallate stearates and a medicinal composition for treating psoriasis and belongs to the technical field of theepigallocatechin gallate stearates. The epigallocatechin gallate stearates and the medicinal composition comprising the epigallocatechin gallate stearates can be used for treating psoriasis.

Description

technical field [0001] The invention belongs to the technical field of epigallocatechin gallate stearate, and in particular relates to the application of epigallocatechin gallate stearate and a pharmaceutical composition for treating psoriasis. Background technique [0002] Psoriasis (Psoriasis), commonly known as psoriasis, is an immune abnormal chronic inflammatory proliferative skin disease determined by polygenic inheritance and stimulated by multiple environmental factors; the main pathological change of psoriasis is epidermal keratinocyte hyperplasia Excessive and abnormal differentiation, parakeratosis, lack of granular layer, skin neovascularization and inflammatory cell infiltration, etc. Its clinical manifestation is mainly that the skin of the affected area repeatedly produces multiple layers of silvery white dry scales, and there are extensive infiltrating erythema and obvious bleeding points under the scales. Most patients have pruritus symptoms. [0003] The e...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P17/06
Inventor 张涛
Owner JIANGHAN UNIVERSITY
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