Application of green tea polyphenols palmitates and medicinal composition for treating psoriasis

Abstract

The invention discloses application of green tea polyphenols palmitates and a medicinal composition for treating psoriasis and belongs to the technical field of the green tea polyphenols palmitates. The green tea polyphenols palmitates and the medicinal composition comprising the green tea polyphenols palmitates can be used for treating psoriasis.

Description

technical field [0001] The invention belongs to the technical field of tea polyphenol palmitate, and in particular relates to the application of tea polyphenol palmitate and a pharmaceutical composition for treating psoriasis. Background technique [0002] Psoriasis (Psoriasis), commonly known as psoriasis, is an immune abnormal chronic inflammatory proliferative skin disease determined by polygenic inheritance and stimulated by multiple environmental factors; the main pathological change of psoriasis is epidermal keratinocyte hyperplasia Excessive and abnormal differentiation, parakeratosis, lack of granular layer, skin neovascularization and inflammatory cell infiltration, etc. Its clinical manifestation is mainly that the skin of the affected area repeatedly produces multiple layers of silvery white dry scales, and there are extensive infiltrating erythema and obvious bleeding points under the scales. Most patients have pruritus symptoms. [0003] The etiology of psorias...

AI Technical Summary

Problems solved by technology

[0004] At present, the drug treatment of psoriasis includes systemic and local treatment of chemical drugs, traditional Chinese medicines, biological agents and their combined application; although there are many existing therapeutic drugs, commonly used Glucocorticoids such as retinoic acid, dithranol, methotrexate, cyclosporine, etanercept, and dexamethasone all have shortcomings: most of the therapeutic effects can only achieve short-term clinical curative effect, and cannot effectively prolong In the remission period of the patient, it is difficult to control the recurrence, and it is even more difficult to cure the disease; most drugs have adverse reactions of varying degrees, which are difficult for patients to tolerate [see "Inner Mongolia Medical Journal" 2012, 44 (6): 707-719 "Psoriasis progress in treatment"]; and some drugs are expensive; in terms of safety, topical medication is better than systemic therapy

The literature has reported the effective therapeutic effect of tea polyphenols on animal models of psoriasis [see "Experimental Dermatology" 2007;16:678–684. "Green tea polyphenol induces caspase14in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model”], the disadvantage is that tea polyphenols are easily oxidized, resulting in poor stability and poor fat solubility, resulting in weak membrane penetration ability, which brings difficulties to its wide application

[0006] Fat-soluble tea polyphenols are fatty acid esters of more than 8 carbons of tea polyphenols developed by researchers in order to overcome the above-mentioned shortcomings of tea polyphenols through chemical modification. It is a monoesterification of the corresponding components of tea polyphenols , a mixture of diesters or polyesters; Green Tea Polyphenols Palmitate (GTPP) is a product of fat-soluble tea polyphenols. Based on its excellent safety and antioxidant properties, it is currently , the tea polyphenol palmitate circulating in the market is mainly used as an antioxidant for edible oils and esters, and there is no report on the application of tea polyphenol palmitate in the treatment of psoriasis

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