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Application of fluevirosines A in preparation of medicine inhibiting tubercle bacillus

An anti-tuberculosis and drug technology, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as difficulties in tuberculosis prevention and control, and the management of tuberculosis patients is not very standardized.

Inactive Publication Date: 2015-05-20
QINGDAO MUNICIPAL HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. However, due to the lack of standardized treatment and management of tuberculosis patients, irregular chemotherapy, and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be more diverse. Drug resistance at the same time, which has caused great difficulties in the prevention and control of tuberculosis

Method used

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  • Application of fluevirosines A in preparation of medicine inhibiting tubercle bacillus
  • Application of fluevirosines A in preparation of medicine inhibiting tubercle bacillus
  • Application of fluevirosines A in preparation of medicine inhibiting tubercle bacillus

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Experimental program
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Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of the compound Fluevirosines A tablet involved in the present invention:

[0012] Take 5 grams of compound Fluevirosines A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Fluevirosines A capsules involved in the present invention:

[0014] Take 5 grams of compound Fluevirosines A, add 180 grams of starch, mix well, and pack into capsules to make 1000 capsules.

experiment example 1

[0015] Experimental example 1: Determination of the absolute concentration of Fluevirosines A against BCG by solid medium dilution method

[0016] Scrape the BCG culture from the slant, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1) Turbidity, that is, to prepare 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0017] Make Fluevirosines A into a high-concentration stock solution with DMSO, dilute the stock solution to the required concentration with 5% Tween-80 sterile ultrapure water, and add the diluted Fluevirosines A to 4ml Middlebrook7H11 agar medium according to the required dose (The medium has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly to make Fluevirosines A, the concentrations are 6.0ug / ml, 4.0ug / ml, 3.0ug / ml, 2...

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Abstract

The invention discloses the application of fluevirosines A in preparation of the medicine inhibiting the tubercle bacillus. The fluevirosines A has remarkable activity for inhibiting the tubercle bacillus and good application prospect. The fluevirosines A belongs to a brand new matrix type, has the advantages of being high in inhibitory activity to the tubercle bacillus and prominent in substantive features, and makes remarkable progress in prevention and treatment of infection of the tubercle bacillus.

Description

technical field [0001] The present invention relates to a new application of the compound Fluevirosines A, in particular to the application of the Fluevirosines A in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. However, due to the lack of standardized treatment and management of tuberculosis patients, irregular chemotherapy, and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be more diverse. Drug resistance at the same time has caused great difficulties in the prevention and control of tuberculosis. Therefore, finding new anti-tuberculosis drugs, especially anti-multidrug resistance anti-tuberculosis drugs, is of great significance to protect people's health. [0003] The compound Fluevirosines A involved in the present invention is a compound published in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/407A61P31/06
Inventor 宫巧俐谢平鲁峻王欣
Owner QINGDAO MUNICIPAL HOSPITAL
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