Matched artemisia apiacea and agastache rugosaus combination medicine, preparation method and application thereof

A technology of cyanol medicine and medicine, which is applied in the field of preparation of cyanolium to combination medicines, can solve the problems of mechanism of action, characteristics and application in the primary stage, and achieve good effect of activity

Inactive Publication Date: 2013-12-25
CHONGQING ACAD OF CHINESE MATERIA MEDICA +3
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With the in-depth research on the pharmacological effects of artemisinin drugs, it has been confirmed that they have anti-malarial, anti-pregnancy, anti-fibrosis, anti-schistosomiasis, anti-toxoplasma gondii, anti-arrhythmia and tumor cytotoxic effects; although these drugs It has a wide range of effects, but its mechanism of action, characteristics and applications are still in its infancy

Method used

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  • Matched artemisia apiacea and agastache rugosaus combination medicine, preparation method and application thereof
  • Matched artemisia apiacea and agastache rugosaus combination medicine, preparation method and application thereof
  • Matched artemisia apiacea and agastache rugosaus combination medicine, preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 Qinghuo extract

[0021] Respectively pulverize the dry product raw materials of Huoxiang and Artemisia annua, respectively weigh 200g after crossing a 40-mesh sieve, and extract Huoxiang volatile oil and Artemisia annua volatile oil respectively by the volatile oil extraction method of "The Pharmacopoeia of the People's Republic of China" (2010 edition); The residues of the two medicinal materials were evaporated to dryness, refluxed and extracted with 70% ethanol 5 times the weight of the medicinal materials for 3 times, the extracts were combined respectively, dried, and the extract was prepared to obtain the alcohol extract of Huoxiang and artemisinin. Weigh a certain amount of Huoxiang volatile alcohol extract, Artemisia annua alcohol extract, Huoxiang volatile oil and Artemisia annua volatile oil according to the ratio of 1:1 of Huoxiang and Artemisia annua to obtain the mixed group I of Qinghuo extract; The volatile oil of fenugree...

Embodiment 2

[0027] The comparison of embodiment 2 medicines to the volatile oil composition of Psyllium

[0028] Gas chromatography / mass spectrometry (GC / MS) method is used to separate and detect the mixed group A of Qinghuo volatile oil, the mixed group B of Qinghuo volatile oil, the mixed group C of the volatile oil of Qinghuo and the mixed group D of the volatile oil of Qinghuo in the embodiment 1. Volatile oil components, and the two-dimensional GC-MC data were processed using the chemometric resolution method (crave). The chromatographic conditions are: chromatographic column: DB-1 (30m×0.2mm); heating program: the initial temperature is 60° C., and it is maintained for 4 minutes. Rise to 220°C at 4°C / min and maintain for 2min; carrier gas (He) flow rate 1.0mL / min; inlet temperature 280°C; split ratio 100:1; injection volume 10μL. The mass spectrometry conditions are: electron bombardment (EI) ion source; electron energy 70eV, ion source temperature 200°C, interface temperature 250°...

Embodiment 3

[0048] Example 3 Application of the mixed group of Qinghuo extract in relieving cough and reducing phlegm

[0049] According to prior art studies, it has been proved that the volatile oils of Artemisia annua and Huoxiang all have the activity of relieving cough and relieving asthma. The Artemisia annua volatile oil and Huoxiang volatile oil prepared in embodiment 1 are respectively used as Artemisia annua volatile oil group and Huoxiang volatile oil group;

[0050] Take 80 female mice weighing 18-20 g, and randomly divide them into 8 groups, 10 in each group, which are blank control group (equal volume of distilled water), Artemisia annua volatile oil group, Huoxiang volatile oil group, and Qinghuo extract mixed group II , medicine pair Qinghuo extract mixed group IV, Qinghu extract mixed group VI and positive control group (dextromethorphan hydrobromide tablets). Animals were administered by intragastric administration according to body weight (5g raw medicinal material / kg),...

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Abstract

The invention provides a matched artemisia apiacea and agastache rugosaus combination medicine, a method for preparing isatin through fresh folium isatidis as the raw material and the application of the matched artemisia apiacea and agastache rugosaus combination medicine. The matched artemisia apiacea and agastache rugosaus combination medicine is characterized in that isatin is added to fresh folium isatidis; after indoxyl is generated, oxygen is supplied to the indoxyl through dissolved oxygen in original soak solution, therefore, through the control of the pH of the system and the control of oxygen in the enzymolysis process, a reaction is carried out in the direction of forming of the isatin; the method is easy, convenient to adopt and controllable; because the fresh folium isatidis directly serves as the reaction material, production cost is effectively reduced; because further oxidization and generation of indoxyl free radicals are controlled to prevent isatin from being generated again and the isatin is directly added to the reaction raw materials, forward-direction balancing of the reaction is achieved.

Description

technical field [0001] The invention relates to a combination of traditional Chinese medicinal materials and medicines, more specifically, a combination medicine of qinghuo medicines, a preparation method and an application thereof. Background technique [0002] Artemisia annua is an annual herb of the genus Artemisia in the family Asteraceae. It has the effects of clearing away heat and relieving heat, and eliminating steam and intercepting malaria. The volatile oil is one of its main effective parts. Huoxiang is an annual or perennial herb of Lamiaceae. Its main component contains volatile oil of Huoxiang, which has antibacterial and antiseptic effects, and also has a therapeutic effect on superficial skin fungal infections. According to reports, the clinical application of Artemisia annua and Huoxiang can enhance the efficacy of clearing heat, relieving summer heat and antimalarial. [0003] The medicinal ingredients in Artemisia annua can be divided into two parts: vola...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/532A61K36/282A61P17/00A61P11/06A61P11/10
Inventor 杨大坚陈新滋卞兆祥吕爱平陈士林徐宏喜陈国庆张毅
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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