Method for extracting alpha-mangostin from garcinia mangostana peel

A technology of mangostin and bamboo skin, applied in the direction of organic chemistry and the like, can solve the problems of large amount of reagents, long time-consuming, many steps, etc., and achieve the effects of less amount of reagents, simple steps, and short time.

Active Publication Date: 2014-11-19
三原金瑞生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of α-mangostin obtained by the method provided by this application is relatively high, and the method has many steps, takes a long time, and consumes a lot of reagents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The method for extracting α-mangostin in mangosteen bark, the steps are as follows:

[0021] 1) After crushing the mangosteen bark, reflux extraction with 9 times its weight of water for 2 times, each time for 2 hours, and then use 9 times its weight of 95% ethanol solution for reflux extraction for 2 times, each time for 2 hours, and combine the extraction of ethanol solution liquid, concentrated under reduced pressure to 2.5 times the weight of the mangosteen bark, cooled to room temperature, centrifuged, and the centrifuged slag was dried to obtain a crude extract, and the α-mangostin content of the crude extract was 75.5%;

[0022] 2) Using the fluid composed of dimethyl ether and butane in a weight ratio of 65:35 as the extractant, the crude extract is subjected to subcritical extraction, the extraction temperature is 70°C, the extraction pressure is 3.0MPa, the extraction time is 30min, and the recovered The finished product is obtained after the self-volatile ext...

Embodiment 2

[0024] The method for extracting α-mangostin in mangosteen bark, the steps are as follows:

[0025] 1) After crushing the mangosteen bark, reflux extraction with 8 times its weight of water for 2 times, each time for 3 hours, then use 8 times its weight of 90%-95% ethanol solution for reflux extraction twice, each time for 3 hours, and combine ethanol The extract of the solution is concentrated under reduced pressure to twice the weight of the mangosteen bark, cooled to room temperature, centrifuged, and the centrifuged slag is dried to obtain a crude extract, and the α-mangostin content of the crude extract is 77%;

[0026] 2) Using the fluid composed of dimethyl ether and butane in a weight ratio of 70:30 as the extractant, the crude extract is subjected to subcritical extraction. The extraction temperature is 70°C, the extraction pressure is 3.2MPa, and the extraction time is 20min. The finished product is obtained after the self-volatile extractant, the product yield of th...

Embodiment 3

[0028] The method for extracting α-mangostin in mangosteen bark, the steps are as follows:

[0029] 1) After crushing the mangosteen bark, reflux extraction with 9 times its weight of water for 2 times, each time for 1 hour, and then use 9 times its weight of 95% ethanol solution for reflux extraction once, each time for 2 hours, extract the ethanol solution The liquid is concentrated under reduced pressure to 2.5 times the weight of the mangosteen bark, cooled to room temperature, centrifuged, and the centrifuged residue is dried to obtain a crude extract, and the α-mangostin content of the crude extract is 70%;

[0030] 2) Using the fluid composed of dimethyl ether and butane in a weight ratio of 60:35 as the extractant, the crude extract is subjected to subcritical extraction, the extraction temperature is 72°C, the extraction pressure is 2.8MPa, the extraction time is 30min, and the recovered The finished product is obtained after the self-volatile extractant, the product ...

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PUM

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Abstract

The invention discloses a method for extracting alpha-mangostin from garcinia mangostana peel. The method includes the following steps that 1) the garcinia mangostana peel is crushed, reflux extraction is conducted once or twice with water of 8-10 times of weight, then reflux extraction is conducted for one to three times with a 90%-95% ethanol solution of 8-10 times of weight, an extracting solution of the ethanol solution is combined, the extracting solution is concentrated to be twice or three times of the weight of the garcinia mangostana peel, centrifuging is carried out, and after centrifugal residues are dried, a crude extract is obtained; 2) subcritical extraction is conducted by using the fluid which is formed by dimethyl ether and butane according to the weight ratio of 60-70 : 30-40 as an extraction agent, the extraction temperature is 68-72 DEG C, the extraction pressure is 2.8-3.2MPa, and the extraction time is 20-40min. According to the method for extracting the alpha-mangostin from the garcinia mangostana peel, water extraction and alcohol extraction are used for obtaining the crude extract first in the extracting process, the content of the alpha-mangostin of the crude extract is 70%-80%, then subcritical extraction is conducted, and the content of the alpha-mangostin is further made to reach 98%. The method is short in time, small in dosage of reagents, simple in step and high in yield and content, a subcritical extraction agent is volatilized directly to obtain a product, and thus the method is more suitable for industrial production.

Description

technical field [0001] The invention relates to a preparation method of a plant extract, in particular to a method for extracting α-mangostin from mangosteen bark. Background technique [0002] Mangosteen (Garcinia mangostana), also known as mangosteen, mangosteen, mangosteen, mangosteen, phoenix fruit, is the fruit of the evergreen tree mangosteen of the genus Garcinia in the family Guttiferae. Because mangosteen peel contains α-mangostin and other active ingredients, it is often used to treat abdominal pain, diarrhea, dysentery, infectious wounds, suppuration, chronic ulcers, leucorrhea, gonorrhea and other diseases. In recent years, α-mangostin in mangosteen peel has become a research hotspot. At present, many patent documents of α-mangostin extracted from mangosteen peel have been disclosed. [0003] For example, CN101396101B discloses a mangosteen extract rich in α-, β- and γ-mangostin and its production process, including crushing, multi-stage extraction, vacuum conc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/86
Inventor 文继承蒋元勇朱昂辉雍小军易华李丽金
Owner 三原金瑞生物工程有限公司
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