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Preparation method for ZCHH tablets and method for reversing drug tolerance of MRSA (Methicillin-Resistant Staphylococcus Aureus) by using ZCHH and antibiotic together

A technology of antibiotics and drug resistance, applied in biochemical equipment and methods, antibacterial drugs, medical preparations containing active ingredients, etc., to achieve simple production process, reduce drug resistance, save human resources and capital investment

Inactive Publication Date: 2014-01-01
曾春晖
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Problems solved by technology

[0026] The purpose of the embodiments of the present invention is to provide a preparation method of ZCHH tablets and a method for reversing MRSA drug resistance by combining ZCHH and antibiotics, aiming to solve the problem of how to reverse the blind area of ​​MRSA drug resistance faced by human beings with scientific and rational combination drugs

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  • Preparation method for ZCHH tablets and method for reversing drug tolerance of MRSA (Methicillin-Resistant Staphylococcus Aureus) by using ZCHH and antibiotic together
  • Preparation method for ZCHH tablets and method for reversing drug tolerance of MRSA (Methicillin-Resistant Staphylococcus Aureus) by using ZCHH and antibiotic together

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[0049] Such as figure 1Shown, the preparation method of the ZCHH tablet that the embodiment of the present invention provides comprises the following steps:

[0050] Mix the medicine ZCHH and lactose evenly, the weight ratio of ZCHH and lactose is 40:9;

[0051] Make wet granules with 10% starch slurry, pass through a 16-mesh sieve, and dry the wet granules at 60-70°C;

[0052] Whole grains, adding 1% magnesium stearate of the total weight of the grains;

[0053] Compression molding is made into ZCHH tablets.

[0054] figure 2 The flow chart of the method for reversing MRSA drug resistance provided by the invention is shown by using ZCHH in combination with antibiotics. For ease of illustration, only the parts relevant to the present invention are shown.

[0055] Such as figure 2 As shown, another object of the embodiments of the present invention is to provide a method for reversing MRSA drug resistance by using ZCHH and antibiotics in combination. The method for reve...

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Abstract

The invention discloses a preparation method for ZCHH tablets and a method for reversing the drug tolerance of MRSA (Methicillin-Resistant Staphylococcus Aureus) by using ZCHH and an antibiotic together. The preparation method comprises the following steps: thoroughly mixing ZCHH with lactose according to the weight ratio of the ZCHH to the lactose of 40 to 9; preparing wet granules with starch slurry of 10%; treating the wet granules with a 16-mesh sieve; drying at 60-70 DEG C; after granule straightening, adding magnesium stearate of which the weight is 1% of that the granules to the granules; compressing to form the ZCHH tablets. The method for reversing the drug-tolerance of the MRSA by using the ZCHH and the antibiotic together comprises the following steps: MRSA strains are isolated clinically; only ZCHH as well as both ZCHH and a beta-lactam antibiotic are applied to in vitro bacteriostasis; only ZCHH as well as both ZCHH and a beta-lactam antibiotic are applied to in vivo bacteriostasis; the structural hierarchies of the cell walls and cell membranes of the MRSA bodies are observed; statistical analysis is performed on the in vivo and in vitro antibiosis effects of the ZCHH and the beta-lactam antibiotics which are used together. According to the invention, the dead zone of action mechanism that the drug tolerance of the MRSA is reversed through drug combination is filled up, and an important theoretical basis is provided for clinical medication.

Description

technical field [0001] The invention belongs to the field of combination medicine, and in particular relates to a preparation method of ZCHH tablet and a method for reversing MRSA drug resistance by combined use of ZCHH and antibiotics. Background technique [0002] MRSA is an abbreviation for methicillin-resistant Staphylococcus aureus. Staphylococcus aureus is a very common germ. According to surveys, about 25-30% of people grow this germ in their nasal cavity, and it is often found on the skin of healthy people. Sometimes it gets into the body and causes an infection. The infection can range from mild sores and pimples on the skin to pneumonia or blood infection. Infections caused by staph bacteria are usually treated with the penicillin-type antibiotic methicillin, which is very effective in most cases. But some strains of staph have developed resistance to methicillin, known as MRSA. [0003] The prevalence of Methicillin-resistant Staphylococcus (MRSA) infection ha...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/352A61K45/00A61P31/04C12Q1/18
Inventor 曾春晖杨柯李先梅谭娥玉蔡妮娜徐明光陈益清颜欣秦树森
Owner 曾春晖
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