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A kind of amphiphilic polymer coated retinoid coated micelles and cosmetic composition

A cosmetic composition, amphiphilic polymer technology, applied in the field of polymer materials and applied chemistry, can solve the problems of not being used, affecting the appearance of products, etc., and achieve the effect of improving stability

Active Publication Date: 2015-08-26
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The currently reported coatings for vitamin A are mainly made of liposomes and solid microcapsules, which can be added to cream cosmetics, but when added to lotion cosmetics, they are not used because they obviously affect the appearance of the product

Method used

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  • A kind of amphiphilic polymer coated retinoid coated micelles and cosmetic composition
  • A kind of amphiphilic polymer coated retinoid coated micelles and cosmetic composition
  • A kind of amphiphilic polymer coated retinoid coated micelles and cosmetic composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of polymer-coated retinoid coated micelles

[0023] Random polymer P(MMA- co -MAA) The preparation method of coated retinoid coated micelles is as follows: 20~100mg polymer P(MMA- co -MAA) and 1~20mg retinoids dissolved in 5mL co-solvent DMF, add this mixed solution dropwise to 20mL ultrapure water, continue to stir for 24h, put it into a dialysis bag for 3 days for dialysis, changing three times a day Water; Pass the dialysate through a 0.45μm filter membrane to remove the co-solvent to obtain a polymer-coated retinoid coated micelle solution, which is freeze-dried to become a micelle freeze-dried powder.

[0024] Weigh the oil phase (A) according to the formula and heat it until it melts. After mixing it with the water phase, shear it for 2 to 6 minutes at a speed of 10,000 to 30,000 r / min of the homogenizer. Then add the retinoid coated micellar powder and stir evenly. The oil phase includes one or more of caprylic triglyceride, capric triglyceride,...

Embodiment 2

[0025] Example 2 Lip Balm Formula

[0026]

Embodiment 3

[0027] Example 3 Cream formula

[0028]

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Abstract

The invention provides amphiphilic polymer-coated retinoid micelle and a cosmetic composition, and belongs to the technical field of high polymer materials and applied chemistry. The amphiphilic polymer-coated retinoid micelle is prepared by a dialysis method and is processed by freeze drying to prepare a powder preparation; the retinoid micelle is added to the cosmetics composition. The test result shows that the amphiphilic polymer-coated retinoid micelle can obviously improve the stability of retinoid and realizes the slow release of the retinoid. The prepared amphiphilic polymer-coated retinoid micelle can be applied to various retinoid-containing cosmetic compositions, such as paste, cream, emulsion and liquid, and overcomes the defects of the application of lipidosome and solid microcapsules in toning lotion and the like.

Description

Technical field [0001] A retinoid coated micelle coated with amphiphilic polymer and a cosmetic composition belong to the technical field of polymer materials and applied chemistry. Background technique [0002] Vitamin A is one of the essential nutrients for the human body. It has a wide range of biological functions in regulating and controlling the proliferation and differentiation, growth and development, morphogenesis, metabolism, stable balance of the internal environment, dark vision and reproduction of a variety of normal tissues and epithelial cells. Activity, especially plays a key role in maintaining the integrity of epithelial cells and activating skin cells. It can effectively increase the activity of skin cells and make the skin bright and elastic. Therefore, many cosmetics at home and abroad contain vitamin A as an active ingredient. [0003] However, vitamin A as a biologically active additive for skin care products in cosmetics also has many shortcomings, mainly d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/67A61K8/81A61K8/04A61K8/11A61Q19/00
Inventor 曹玉华卓小露倪鑫炯徐晓进曹光群
Owner JIANGNAN UNIV