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Peptide-crosslinked bioactive polymeric materials

A technology of cross-linked polymers and bioactive peptides, applied in the field of bioactive polymer materials

Inactive Publication Date: 2014-02-26
THE UNIVERSITY OF AKRON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, regardless of their biological origin, conventional poly(α-amino acids) possess unique physical, chemical, and biodegradable properties that limit their synthetic utility

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  • Peptide-crosslinked bioactive polymeric materials
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  • Peptide-crosslinked bioactive polymeric materials

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Embodiment Construction

[0057] The present invention describes an effort to develop a new class of crosslinked, mechanically robust polymeric materials for orthopedic applications. In addition to conferring specific osteogenic signaling motifs, this approach includes enhancing mechanical properties. To mechanically strengthen polymers and stimulate specific biological activities, the present invention includes OGP-based cross-linkers. Peptide-crosslinked phenylalanine- and leucine-based poly(esterurea) (PEU) homopolymers were synthesized and utilized 0.5% and 1.0% OGP (10-14) tethers. Furthermore, the semi-crystallinity of poly(esterureas) provides a non-chemical means in which mechanical properties, chemical stability, and biodegradation rates can be tuned. This example details chemical, mechanical, in vitro and in vivo data demonstrating the enhanced modulus, biocompatibility and resorbability of poly(ester urea) materials. Further, the data here highlight many opportunities that society will fin...

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Abstract

Provided is a method for preparing a peptide crosslinked bioactive polymeric material. The method includes reacting a hydroxy-functionalized small molecule with a amino acid to form an amino acid functionalized monomer, reacting the amino acid functionalized monomer with a urea bond former to form a amino acid-based poly(ester urea), and reacting the amino acid-based poly(ester urea) with a peptide based crosslinker to form the peptide crosslinked bioactive polymeric material.

Description

field of invention [0001] The present invention generally relates to bioactive polymeric materials. In specific embodiments, the present invention relates to bioactive polymeric materials for in vivo regenerative medicine applications. In other embodiments, the present invention relates to peptide-crosslinked polymeric materials for in vivo use, and in particular embodiments to peptide-crosslinked amino acid-based poly(esterurea) (PEU) materials that provide biological activity in vivo . In other embodiments, the present invention provides peptide cross-linked amino acid PEU materials that provide osteoinductive activity. In other embodiments, the present invention provides specific scaffold structures formed from peptide cross-linked amino acid PEU materials. Background of the invention [0002] Synthetic degradable polymers have been used in various ways for regenerative medicine and orthopedic applications. However, they generally lack the mechanical properties necess...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/00
CPCC07K7/06C08F222/385C07K7/08
Inventor M·贝克M·格雷姆F·哈里斯林飞
Owner THE UNIVERSITY OF AKRON