Application of hydrogen sulfide and donor thereof sodium hydrosulfide to preparation of medicament for treating diabetes

A diabetes drug, sodium hydrosulfide technology, applied in the direction of drug combination, urinary system diseases, metabolic diseases, etc., can solve problems such as adverse side effects, inappropriate use, etc., to increase insulin levels, reduce oxidative stress, and prevent diabetic kidney disease Sign effect
CN103622992AActive Publication Date: 2014-03-12FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2014-03-12

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Abstract

The invention belongs to the field of pharmacy, relates to novel medicinal application of hydrogen sulfide and a donor thereof sodium hydrosulfide to pharmacy, and in particular relates to application of hydrogen sulfide and donor thereof sodium hydrosulfide to preparation of medicament for treating diabetes. The invention adopts the exogenous hydrogen sulfide and its donor sodium hydrosulfide (NaHS) for insulin sensibilization and tests for regulating blood sugar level and increasing insulin level for type II diabetes. Through correlation test of skeletal muscle and adipose cells with insulin resistance, insulin tolerance test by using animal model for diabetes insulin resistance, glucose consumption experiment, animal model experiment for diabetes insulin resistance and NaHS intervention animal experiment, the results show that NaHS can promote glucose uptake in the presence of insulin, thus indicating insulin enhancement effect. The invention of hydrogen sulfide and the donor thereof sodium hydrosulfide can be used as insulin sensitizers and medicaments for regulating blood sugar level and increasing insulin level for type II diabetes.
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Description

technical field

[0001] The invention belongs to the field of medicine and pharmacy, and relates to the new medicinal application of hydrogen sulfide and its donor sodium hydrosulfide in pharmacy, in particular to the application of hydrogen sulfide and its donor sodium hydrosulfide in the preparation of medicines for treating diabetes. The hydrogen sulfide and its donor sodium hydrosulfide can be used as an insulin sensitizer and a drug for lowering blood sugar and increasing insulin level for type II diabetes. Background technique

[0002] The prior art discloses hydrogen sulfide (H 2 S) is a metabolite of cysteine ​​in the human body. Its content in the human body is very low, about 20-50 μmol / L, and it is not easy to be controlled artificially. It is also reported in the literature that H 2 S is a new type of endogenous gas molecule involved in the regulation of cardiovascular activity, and has the purpose of promoting angiogenesis in cardiovascular diseases.

[0003] A...

Claims

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