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A kind of topical sustained-release preparation for treating periodontal disease

A local drug delivery and sustained-release preparation technology, which is applied to medical preparations containing no active ingredients, medical preparations containing active ingredients, antibacterial drugs, etc., can solve problems such as poor adhesion of periodontal pockets, and achieve uniform drug delivery. medicine, easy application, good curative effect

Active Publication Date: 2015-07-29
哈药集团中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention solves the problem of poor adhesion of sustained-release preparations in periodontal pockets, and provides a locally administered sustained-release preparation for the treatment of periodontal disease

Method used

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  • A kind of topical sustained-release preparation for treating periodontal disease
  • A kind of topical sustained-release preparation for treating periodontal disease
  • A kind of topical sustained-release preparation for treating periodontal disease

Examples

Experimental program
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Effect test

specific Embodiment approach 1

[0016] Specific embodiment 1: A kind of topical sustained-release preparation for treating periodontal disease according to this embodiment is composed of 1 to 5 parts of antibiotics, 50 to 200 parts of organic solvents and 50 to 200 parts of α-cyanide base acrylate composition.

[0017] The drug sustained-release preparation of this embodiment can be firmly attached to the periodontal pocket and will not fall off with the movement of the oral cavity. good.

[0018] In this embodiment, α-cyanoacrylate is used as the main matrix, and α-cyanoacrylate is used as a chemical adhesive, which can be used for bonding surgical incisions in surgical operations. The compound is an instant adhesive that cures within seconds when exposed to water for an extremely strong bond. At the same time, in the body fluid environment, α-cyanoacrylate will gradually degrade and disappear. Long-chain cyanoacrylates such as α-n-butyl cyanoacrylate and α-n-octyl cyanoacrylate are commonly used in medi...

specific Embodiment approach 2

[0021] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is that the local administration sustained-release preparation for treating periodontal disease is composed of 1-4 parts of antibiotics, 50-150 parts of organic solvent and Composed of 50-150 parts of α-cyanoacrylate. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0022] Specific embodiment 3: The difference between this embodiment and specific embodiment 1 or 2 is that the local administration slow-release preparation for treating periodontal disease is composed of 1-3 parts of antibiotics, 50-120 parts of organic It consists of a solvent and 50-120 parts of α-cyanoacrylate. Others are the same as in the first or second embodiment.

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Abstract

The invention provides a local medicine delivery sustained-release preparation for treating periodontosis, and relates to a local medicine delivery sustained-release for periodontosis, and the preparation is used for solving the problem that a sustained-release preparation is poor in adhesive force. The sustained-release preparation is prepared from the following components in parts by weight: 1-5 parts of antibiotics, 50-200 parts of organic solvent, and 50-200 parts of alpha-cyanoacrylate; or prepared from 1-5 parts of antibiotics, 50-200 parts of a frame component, 50-200 parts of organic solvent, and 50-200 parts of alpha-cyanoacrylate. The sustained-release preparation can be firmly adhered in a periodontal pocket, cannot fall off along with motion of an oral cavity, has an excellent sustained-release effect, can achieve the aim of long-time uniform delivery, is easily applied by patients, and is excellent in curative effect. The local medicine delivery sustained-release preparation is applicable to the field of odontopathy treatment.

Description

technical field [0001] The invention relates to a sustained-release preparation for local administration of periodontal disease. Background technique [0002] Periodontal disease is a common oral disease, one of the main causes of adult tooth loss, and a major oral disease that endangers human teeth and general health. According to the third national oral health epidemiological survey in 2005, 80%-97% of Chinese adults suffer from periodontal disease in varying degrees. [0003] The harm of periodontal disease is not limited to the oral cavity, but is closely related to many systemic diseases, such as cardiovascular disease, diabetes, adverse pregnancy, lung infection, digestive tract disease, rheumatoid arthritis, etc. [0004] Periodontal disease is extremely harmful to human health, so research on the treatment of periodontal disease continues to deepen. However, periodontal disease is still an extremely difficult disease to treat clinically. [0005] Local periodontal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K45/00A61P31/04A61P1/02
Inventor 刘玠刘秋丽赵鲁元陈玉颜莉解黎雯李殿明崔仁海王英新
Owner 哈药集团中药有限公司
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