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Hyaluronic acid decomposition inhibitor comprising rosemary extract and retinol acetate

A technology of rosemary extract and retinyl acetate is applied in the directions of skin care preparations, medical preparations containing active ingredients, active ingredients of hydroxyl compounds, etc. Effects of preventing aging and enhancing hyaluronidase inhibitory effect

Inactive Publication Date: 2014-03-12
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In this document, although there are records about hyaluronidase inhibitory substances extracted by any of rosemary, thyme or melissa, their mixtures, and mixtures with other antiallergic agents, but for exerting more than There is no description of such mixtures as synergistic effects of additive effects

Method used

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  • Hyaluronic acid decomposition inhibitor comprising rosemary extract and retinol acetate
  • Hyaluronic acid decomposition inhibitor comprising rosemary extract and retinol acetate
  • Hyaluronic acid decomposition inhibitor comprising rosemary extract and retinol acetate

Examples

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Embodiment

[0053] Next, although an Example is given and this invention is demonstrated further in detail, the technical scope of this invention is not limited at all by this. In addition, the compounding quantity is all mass %.

manufacture example

[0054] Production example: Production of rosemary extract

[0055] A 50% by mass 1,3-butanediol aqueous solution was added to what finely chopped 10 kg of rosemary leaves, and the mixture was immersed at room temperature for 7 to 10 days. After dipping, filter to remove unnecessary substances, and further incubate the filtrate at low temperature for 7 to 10 days. After incubation, filtration was performed to remove unnecessary substances to obtain rosemary extract BG.

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PUM

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Abstract

The present invention relates to the provision of a hyaluronidase inhibitor having an excellent hyaluronidase inhibitory activity. More specifically, a hyaluronidase inhibitor is provided, which comprises a rosemary extract that has a hyaluronidase inhibitory activity and retinol acetate that can enhance the hyaluronidase inhibitory activity of the rosemary extract.

Description

technical field [0001] The present invention relates to a hyaluronidase inhibitor having an excellent hyaluronidase inhibitory effect. Background technique [0002] In recent years, research progress related to aging. As for the cause of skin aging, aging is an important factor macroscopically, but other factors such as dryness, oxidation, and sunlight (ultraviolet rays) can also be cited as direct factors related to skin aging. As specific phenomena of skin aging, reduction of mucopolysaccharides represented by hyaluronic acid, cross-linking reaction of collagen, cell damage by ultraviolet rays, and the like are known. [0003] Among them, among linear polymer polysaccharides in which β-D-N-acetylglucosamine and β-D-glucuronic acid are alternately combined, they are widely present in mammalian connective tissue together with chondroitin sulfate and the like. Hyaluronic acid, one of the glycosaminoglycans, has the functions of maintaining water in the intercellular space, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K8/67A61K8/97A61K36/00A61P37/08A61Q19/00
CPCA61K8/97A61K8/671A61Q19/08A61K8/9789A61K2800/782A61P1/02A61P17/00A61P17/02A61P17/10A61P17/16A61P19/08A61P29/00A61P37/08A61P43/00A61Q19/007A61K31/07A61K36/53A61Q19/00A61K8/67A61K2121/00
Inventor 饭野雅人落合信彦常长诚
Owner SHISEIDO CO LTD