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Antioxidant

A technology of antioxidants and compounds, used in anti-inflammatory agents, anti-toxic agents, digestive systems, etc., can solve problems such as difficult and safe use

Active Publication Date: 2011-10-12
MORINAGA MILK IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such antioxidants may be carcinogens (eg, Non-Patent Document 3) and are difficult to use safely

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0280] ApoE gene-deficient mice with atherosclerosis were used as model animals to test cyclolanostane compounds, 4-methyl-7-encholestanol compounds, and cyclolanostane compounds and 4-methyl-7-encholestanol compounds The effect of a mixture of stanol compounds in inhibiting the formation of lipid peroxides.

[0281] (1) Sample preparation

[0282] 9,19-Cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol prepared in Preparation Example 1 above were used as Test Sample 1 and Test Sample 2, respectively.

[0283] 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol, and 4-methylstigmasterol of the test sample test sample test sample prepared in Preparation Example 2 above -7-en-3-ol was used as Test Sample 3, Test Sample 4 and Test Sample 5, respectively.

[0284] The mixture of the cyclolanostane compound and the 4-methyl-7-encholestanol compound (cyclolanostane compound: 4-methyl-7-encholestane) of the test sample prepared in Preparation Example 3 above Alcohol compo...

Embodiment 2

[0299]In Example 2, using known arteriosclerosis model animals, ApoE gene-deficient mice, by calculating the number of atherosclerotic lesions (plaques) in the arteries, cyclolanostane compounds, 4-methyl-7-ene Cholesterol compounds, and a mixture of cyclolanostane compounds and 4-methyl-7-ene cholestanol compounds have the effect of reducing the risk of arteriosclerosis by inhibiting the action of lipid peroxides.

[0300] (1) Sample preparation

[0301] Test samples 1-6, control samples and negative samples were prepared in the same manner as in Example 1 above, and used for testing respectively.

[0302] (2) Test method

[0303] Six-week-old male ApoE gene-deficient mice (purchased from SLC Japan) were initially fed with a high-cholesterol diet (manufactured by Research Diets) for 2 weeks and divided into groups of 15 mice each.

[0304] Using a medical probe, each group of mice was orally given a sample solution containing a test sample, a control sample or a negative sa...

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Abstract

Provided is an antioxidant which is highly safe, inhibits oxidation of biological components, in particular, lipids and is usable as a drug, a food or a drink, a food additive, an external skin preparation and so on. A compound selected from a cyclolanostane compound and a rophenol compound is used as the active ingredient of an antioxidant.

Description

technical field [0001] The present invention relates to antioxidants useful as medicines, foods or beverages, food additives, external preparations for skin, and the like. Background technique [0002] "Oxidative stress" is defined as a state in which a living body has a tendency to oxidize due to a dysregulation between the production of reactive oxygen species (ROS) in the living body and the anti-oxidative defense mechanism. That is, excessive production of ROS or decreased antioxidant capacity leads to oxidative stress. [0003] ROS oxidize lipids, especially low-density lipoprotein (LDL) of phospholipids (phopholipid) to form lipid peroxides and oxidized LDL, and oxidatively denature and inactivate proteins, causing oxidative damage to DNA. It is therefore considered that oxidative stress is involved in the occurrence of various diseases such as arteriosclerosis, cancer, various lifestyle-related diseases, Alzheimer's disease and Parkinson's disease and accelerates agi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00A61K31/575A61K36/00A61P1/16A61P9/10A61P27/12A61P39/06C07J53/00A23L29/10
CPCA61K31/575A61P1/16A61P17/00A61P17/14A61P19/02A61P25/16A61P25/28A61P27/02A61P27/12A61P29/00A61P35/00A61P37/06A61P39/06A61P43/00A61P9/00A61P9/10
Inventor 田中美顺野间口光治江原达弥
Owner MORINAGA MILK IND CO LTD
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