Application of tnf-alpha receptor-antibody fusion protein in preparation of medicine for treating diabetic peripheral neuropathy

A fusion protein and α-receptor technology, which can be applied to nervous system diseases, drug combinations, peptide/protein components, etc., and can solve problems such as no related reports

Inactive Publication Date: 2015-09-02
JINSHAN HOSPITAL FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no relevant report on the use of TNF-α receptor-antibody fusion protein to inhibit TNF-α in the treatment of DPN.

Method used

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  • Application of tnf-alpha receptor-antibody fusion protein in preparation of medicine for treating diabetic peripheral neuropathy
  • Application of tnf-alpha receptor-antibody fusion protein in preparation of medicine for treating diabetic peripheral neuropathy
  • Application of tnf-alpha receptor-antibody fusion protein in preparation of medicine for treating diabetic peripheral neuropathy

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Experimental program
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Embodiment Construction

[0026] The specific embodiments provided by the present invention will be described in detail below in conjunction with the accompanying drawings.

[0027] 1. Experimental materials

[0028] Experimental animals: Wistar rats aged 6 weeks (140-160g), male, 60 in total, purchased from the Animal Center of Shanghai Medical College, Fudan University. The use of animals complied with the regulations of the Shanghai Municipal Animal Management Committee. Raised in single cages, the breeding room was quiet, the temperature was kept at 20±2°C, the relative humidity was 60%, the light time was 12h / day, clean drinking water, standard feeding before modeling.

[0029] Clean-grade rat common maintenance feed was purchased from the Animal Center of Shanghai Medical College, Fudan University; high-fat, high-sugar feed, that is, 10% lard and 20% sucrose were added to the clean-grade rat normal maintenance feed , mixed and dried, then irradiated and sterilized.

[0030] Rabbit anti-rat MBP...

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Abstract

The invention provides an application of a TNF (tumor necrosis factor)-alpha receptor-antibody fusion protein, including application of TNF-alpha receptor-antibody fusion protein in preparation of medicaments for treating diabetic peripheral neuropathy (DPN), delaying diabetic peripheral neuropathy and increasing nerve conduction velocity or relieving nerve demyelination. The application provided by the invention has the advantages that the TNF-alpha receptor-antibody fusion protein is applied to a DPN rat model to inhibit the function of TNF-alpha, and the influences of the TNF-alpha receptor-antibody fusion protein on the nerve conduction velocity of a DPN rat, nervous tissue pathological alteration and myelin basic protein expression are observed, so that the action of the TNF-alpha in the pathogenesis of the DPN is made clear, and the effects of the TNF-alpha receptor-antibody fusion protein in delaying the development of peripheral neuropathy of the DPN rat, improving the expression of sciatic nerve morphology of the DPN rat and relieving demyelination of sciatic nerve are proved. Thus, the TNF-alpha receptor-antibody fusion protein has a wide application prospect in the preparation of medicaments for treating diabetic peripheral neuropathy.

Description

technical field [0001] The present invention relates to the use of cytokine TNF-alpha receptor-antibody fusion protein, specifically, the application of TNF-alpha receptor-antibody fusion protein in the preparation of drugs for treating diabetic peripheral neuropathy. Background technique [0002] Diabetes is a common chronic metabolic disease and one of the most prevalent diseases in the world. With the rapid development of social economy, the change of people's lifestyle and the aging of the population, the incidence of diabetes is increasing year by year. According to statistics, the number of diabetic patients in the world has exceeded 100 million. With the rising incidence of diabetes, the incidence of diabetic neuropathy is also increasing. Diabetic neuropathy can be divided into the following categories according to nerve anatomy: peripheral neuropathy, autonomic neuropathy, cranial neuropathy, spinal cord lesions, and brain lesions. Among them, Diabetic Peripheral ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P3/10A61P25/02A61P25/00
Inventor 施晓红陈英辉许国雄李炳陈碧琴
Owner JINSHAN HOSPITAL FUDAN UNIV
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