Calculus-suppressing and pain-alleviating Chinese medicinal composition and preparation method thereof

A technology of composition and traditional Chinese medicine, applied in the directions of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc., can solve the problems of low extraction rate, unable to propose active ingredients, affecting drug efficacy, etc., and achieves remarkable analgesic effect, Significant pain relief, significant therapeutic effect

Inactive Publication Date: 2014-04-23
GUANGXI WUZHOU PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Due to the different properties of the active ingredients in the eight-flavored medicinal materials, if the preparation methods in the above patents all use water extraction, some active ingredients cannot be extracted, or the extraction rate is low, which will affect the efficacy of the drug.

Method used

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  • Calculus-suppressing and pain-alleviating Chinese medicinal composition and preparation method thereof
  • Calculus-suppressing and pain-alleviating Chinese medicinal composition and preparation method thereof
  • Calculus-suppressing and pain-alleviating Chinese medicinal composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] 1) Take the following medicinal materials in parts by weight: 456g of Desmodium glabra, 302g of Corn Stigma, 228g of Shiwei, 228g of Chicken Bone Grass, 228g of Poria Cocos, 165g of Plantain, 165g of Sea Golden Sand Grass, 228g of Imperata Rhizome;

[0078] 2) Add 0.1% sodium bicarbonate solution with mass-volume percentage to extract shiwei, Haijinsha grass, and corn silk twice, adding 0.1% sodium bicarbonate solution 20 times and 15 times the total weight of the medicinal materials respectively, each time The extraction time is 4 hours and 2 hours respectively, the extracts are combined, filtered, and the filtrate is concentrated into a liquid extract;

[0079] 3) Plantago was extracted twice with sodium bicarbonate-ethanol solution, each time adding 0.1% sodium bicarbonate 10% ethanol solution 20 times and 15 times the total weight of the medicinal materials, and the extraction time was 4 hours and 2 hours respectively. hours, combined extracts, filtered, and the fil...

Embodiment 2

[0083] 1) Take the following medicinal materials in parts by weight: 456g of Desmodium glabra, 302g of Corn Stigma, 228g of Shiwei, 228g of Chicken Bone Grass, 228g of Poria Cocos, 165g of Plantain, 165g of Sea Golden Sand Grass, 228g of Imperata Rhizome;

[0084] 2) Extract 3 times with 1% sodium bicarbonate solution of Shiwei, Haijinsha grass, and corn silk with 1% mass-volume percentage, and add 1% sodium bicarbonate in an amount of 20 times, 15 times, and 10 times the total weight of the medicinal materials respectively solution, each extraction time is 4 hours, 2 hours, and 1 hour respectively, the extracts are combined, filtered, the filtrate is concentrated to a clear paste with a relative density of 1.10 at 80°C, and dried into a liquid extract;

[0085] 3) Plantago was extracted with sodium bicarbonate-ethanol solution for 3 times, each time adding 5% sodium bicarbonate 40% ethanol solution of 20 times, 15 times and 10 times the total weight of the medicinal materials ...

Embodiment 3

[0089] 1) Take the following medicinal materials in parts by weight: 456g of Desmodium glabra, 302g of Corn Stigma, 228g of Shiwei, 228g of Chicken Bone Grass, 228g of Poria Cocos, 165g of Plantain, 165g of Sea Golden Sand Grass, 228g of Imperata Rhizome;

[0090] 2) Add 0.5% mass-volume sodium bicarbonate solution to extract Shiwei, Haijinsha grass, and corn silk for 3 times, and add 0.5% sodium bicarbonate in an amount of 20 times, 15 times, and 10 times the total weight of the medicinal materials respectively solution, each extraction time is 3 hours, 2 hours, and 1 hour respectively, the extracts are combined, filtered, and the filtrate is concentrated into a liquid extract;

[0091] 3) Plantago was extracted with sodium bicarbonate-ethanol solution for 3 times, adding 0.5% sodium bicarbonate in 30% ethanol solution of 20 times, 15 times and 10 times the total weight of the medicinal materials respectively, and each extraction time was 3 hour, 2 hours, 1 hour, combine the ...

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Abstract

The invention relates to a calculus-suppressing and pain-alleviating Chinese medicinal composition and a preparation method thereof. The method for preparing the Chinese medicinal composition mainly comprises the steps of preparing eight types of medicinal materials, namely snowbell-leaf tickclover herb, corn stigma, pyrrosia leaf, chickenbone herb, Indian buead, plantain herb, Japanese climbing fern spore and cogongrass rhizome; extracting the pyrrosia leaf, Japanese climbing fern spore and corn stigma with an alkaline aqueous solution; extracting the plantain herb with a sodium bicarbonate-ethanol solution; extracting the snowbell-leaf tickclover herb, cogongrass rhizome, chickenbone herb and Indian buead with water; finally combining liquid extracts obtained by using the three extraction methods. As proved by the results of animal pharmacological experiments and clinical tests, the Chinese medicinal composition provided by the invention has better calculus-suppressing and pain-alleviating effects than the prior art in the treatment of urinary systematic calculi.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating calculi in the urinary system, in particular to a traditional Chinese medicine composition for stone suppression and analgesia and a preparation method thereof. Background technique [0002] Urinary system stones belong to the scope of "sand stranguria", "stone stranguria" and "blood stranguria" in TCM gonorrhea, mainly including 4 syndrome types: [0003] (1) Qi stagnation and blood stasis type: Symptoms include dull pain in the waist, dull pain, normal or tight pulse, and normal tongue; or sudden interruption of urination during drowning, severe pain that extends to the waist and abdomen, and the pain is relieved after the discharge of sand and stones; or Pain in the waist and flanks, which is like twisting, causing the lower abdomen, frequent attacks, pale complexion, cold sweat, nausea, accompanied by blood in the urine or yellowish urine, dark red tongue or petechiae,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P13/04
Inventor 张栩颜郑志远刘冠萍林艳英梁云飞陈瑛兰星
Owner GUANGXI WUZHOU PHARMA GRP
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