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Nonoxynol vaginal expansion suppository, as well as preparation method and detection method thereof

The technology of vaginal expansion suppository and nonoxynol is applied in the directions of suppository delivery, pharmaceutical formulation, material inspection product, etc., which can solve the problems of difficult cleaning, no obvious improvement in suppository stability, small contact surface of active ingredients, etc., to prevent outflow. Effect

Active Publication Date: 2014-04-30
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Nonoxynol suppository is included in the Chinese Pharmacopoeia 2010 edition two, in addition CN101327187 also discloses a kind of nonoxynol suppository, and this suppository comprises the nonoxynol ether of 1 weight part, the polyethylene glycol 1000 of 2 weight parts and 13 parts by weight of mixed fatty acid glycerides; the suppository has improved the irritation of the common nonoxynol suppository to the vagina, but the stability of the suppository has not been significantly improved; meanwhile, the common nonoxynol suppository is used for intravaginal administration It must be placed deep into the vagina 5 minutes before intercourse, otherwise it will easily lead to contraceptive failure; in addition, ordinary nonoxynol suppositories are not easy to clean and easily contaminate clothes; the active ingredient has a small contact surface with the human body, resulting in insufficient absorption. Technical problems such as not giving full play to the best curative effect of the prescription

Method used

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  • Nonoxynol vaginal expansion suppository, as well as preparation method and detection method thereof
  • Nonoxynol vaginal expansion suppository, as well as preparation method and detection method thereof
  • Nonoxynol vaginal expansion suppository, as well as preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090]

[0091] Preparation:

[0092] 1) Preparation of drug-containing matrix:

[0093] a. placing propylene glycol stearate and cocoa butter in a water bath for heating and melting, and mixing uniformly to obtain a melt;

[0094] B. take the nonoxynol ether of recipe quantity, mix with the melt of step a, make the matrix containing medicine;

[0095] 2) Pour the drug-containing matrix into the suppository mold, insert the tampon, cool and shape, and make 100 stick-shaped suppositories, each weighing about 2.0g.

Embodiment 2

[0097]

[0098] Preparation:

[0099] 1) Preparation of drug-containing matrix:

[0100] a. Place the semi-synthetic fatty acid glyceride in a water bath to heat and melt, add isopropyl lanolin ester under stirring, and mix evenly to obtain a melt;

[0101] B. take the nonoxynol ether of recipe quantity, mix with the melt of step a, make the matrix containing medicine;

[0102] 2) Pour the drug-containing matrix into the suppository mold, insert the tampon, cool and shape, and make 100 spherical suppositories, each weighing about 0.5g.

Embodiment 3

[0104]

[0105] Preparation:

[0106] 1) Preparation of drug-containing matrix:

[0107] a. Put polyethylene glycol 4000 and polyethylene glycol 6000 in a water bath to heat and melt, add isopropyl lanolate under stirring, and mix evenly to obtain a melt;

[0108] b. Put maltodextrin in a mortar, slowly add nonoxynol ether under grinding, continue grinding, then add lactitol, continue grinding for 0.5h, take it out, and pass through a 120-mesh sieve to obtain the ground product;

[0109] c. Add the grind in step b to step a, and mix evenly to prepare a drug-containing matrix;

[0110] 2) Pour the drug-containing matrix into the suppository mold, insert the tampon, cool and shape, and make 100 cylindrical suppositories, each weighing about 2.3g.

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Abstract

The invention relates to a nonoxynol vaginal expansion suppository, as well as a preparation method and a detection method thereof. The expansion suppository comprises nonoxynol, a matrix and an expandable expansion carrier, wherein a medicine-containing matrix formed by the nonoxynol and the matrix is coated on the surface of the expansion carrier; isopropyl lanolate, carbomer, stearyl alcohol and lauric isopropanolamide are further added in the medicine-containing matrix, and the prepared expansion suppository has the advantages of high stability, good bioavailability and small vaginal irritation; and furthermore, the nonoxynol vaginal expansion suppository further applies six unique advanced technologies and further has the beneficial effects of preventing medicine liquid from flowing to the outside, washing vagina, keeping an acidic environment of the vagina and the like.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a nonoxynol vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] Nonoxynol ether is an anhydrous mixture formed by polycondensation of nonylphenol and ethylene oxide. It is a colorless to white viscous liquid, odorless, and easily condenses below 10°C; nonoxynol ether belongs to the category of non-ionic surfactants Birth control pills mainly kill sperm or prevent sperm from swimming by reducing the surface tension of sperm lipid membrane and changing sperm osmotic pressure, so that sperm cannot enter the cervix and cannot fertilize eggs, so as to achieve the purpose of contraception. At present, clinically commonly used nonoxynol preparations include nonoxynol vaginal tablets, nonoxynol suppositories and nonoxynol films, wherein the vaginal tablets are slow to take effect due to the disintegration process; the fil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K31/085A61K47/14A61K47/40A61K47/18A61K47/32G01N33/15G01N5/04A61P15/18
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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