Traditional Chinese medicine preparation for treating ankylosing spondylitis
A technology of ankylosing spondylitis and traditional Chinese medicine preparations, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., and can solve the problems of expensive immunosuppressants, unfavorable drug safety, and large side effects problem, to achieve the effect of inhibiting ankle swelling, low toxic and side effects, and low cost
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Embodiment 1
[0016] Embodiment 1, the preparation of the traditional Chinese medicine preparation for the treatment of ankylosing spondylitis
[0017] Raw material composition:
[0018] component
prescription 1
prescription 2
prescription 3
prescription 4
prescription 5
Salvia (g)
196
206
216
226
236
64
59
54
57
40
Angelica (g)
120
104
108
102
96
Achyranthes (g)
140
150
162
170
180
Pueraria (g)
196
206
216
226
236
[0019] Formulation preparation:
[0020] A. Preparation of traditional Chinese medicine extracts: According to the composition of the raw materials of prescriptions 1 to 5, firstly take four medicinal materials except Panax notoginseng, add water equivalent to 10 times the total weight of the medicinal materials, soak for 30 minutes, decoct for 2 hours, filter, collect Filtrate; add water equivalent to 10 times th...
Embodiment 2
[0022] Embodiment 2, the pharmacodynamics study of the traditional Chinese medicine preparation for the treatment of ankylosing spondylitis
[0023] 1. Effects on adjuvant-induced ankle swelling in rats
[0024] Male SD rats weighing about 180 g were taken and randomly divided into 5 groups: model control group, high, medium and low dose groups of traditional Chinese medicine preparations and positive drug (Tongluo Kaibi Tablet) control group, with 10 rats in each group. Before the test, the ankle joint circumference (cm) of the left and right hind limbs of all rats was measured with a soft ruler as the basic value, and then 0.1 ml of Freund's complete adjuvant was injected intradermally into the right hind foot pad of all rats to induce inflammation. From the second day after the induction of inflammation, the model control group was gavaged with normal saline at a dose of 1.5 mL / 100g (body weight); the high, medium and low dose groups of traditional Chinese medicine preparat...
Embodiment 3
[0047] Example 3. Toxicological study of traditional Chinese medicine preparations for the treatment of ankylosing spondylitis
[0048] According to the "Technical Guidance Principles for Acute Toxicity Research of Traditional Chinese Medicines and Natural Medicines", acute toxicity research was carried out on the traditional Chinese medicine preparation for treating ankylosing spondylitis according to the present invention. The Kunming mice, half male and half female, were randomly divided into two groups: the experimental group and the control group. Fasting for 12 hours before the experiment, the experimental group was given the granule solution prepared in Example 1 according to prescription 3 by gavage at the maximum dose (equivalent to 350.6 g / kg of crude drug, equivalent to 138 times the daily oral dose of an adult). The control group was given an equal volume of normal saline, once in the morning and once in the evening. The body weight, appearance, behavior, excretio...
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