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Traditional Chinese medicine preparation for treating ankylosing spondylitis

A technology of ankylosing spondylitis and traditional Chinese medicine preparations, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations containing active ingredients, etc., and can solve the problems of expensive immunosuppressants, unfavorable drug safety, and large side effects problem, to achieve the effect of inhibiting ankle swelling, low toxic and side effects, and low cost

Inactive Publication Date: 2016-08-24
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, traditional anti-inflammatory drugs often have limited curative effects, although immunosuppressants have relatively good curative effects but are expensive, and other types of drugs except natural plants have large side effects, which is not conducive to drug safety.

Method used

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  • Traditional Chinese medicine preparation for treating ankylosing spondylitis
  • Traditional Chinese medicine preparation for treating ankylosing spondylitis
  • Traditional Chinese medicine preparation for treating ankylosing spondylitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, the preparation of the traditional Chinese medicine preparation for the treatment of ankylosing spondylitis

[0017] Raw material composition:

[0018] component

prescription 1

prescription 2

prescription 3

prescription 4

prescription 5

Salvia (g)

196

206

216

226

236

Panax notoginseng (g)

64

59

54

57

40

Angelica (g)

120

104

108

102

96

Achyranthes (g)

140

150

162

170

180

Pueraria (g)

196

206

216

226

236

[0019] Formulation preparation:

[0020] A. Preparation of traditional Chinese medicine extracts: According to the composition of the raw materials of prescriptions 1 to 5, firstly take four medicinal materials except Panax notoginseng, add water equivalent to 10 times the total weight of the medicinal materials, soak for 30 minutes, decoct for 2 hours, filter, collect Filtrate; add water equivalent to 10 times th...

Embodiment 2

[0022] Embodiment 2, the pharmacodynamics study of the traditional Chinese medicine preparation for the treatment of ankylosing spondylitis

[0023] 1. Effects on adjuvant-induced ankle swelling in rats

[0024] Male SD rats weighing about 180 g were taken and randomly divided into 5 groups: model control group, high, medium and low dose groups of traditional Chinese medicine preparations and positive drug (Tongluo Kaibi Tablet) control group, with 10 rats in each group. Before the test, the ankle joint circumference (cm) of the left and right hind limbs of all rats was measured with a soft ruler as the basic value, and then 0.1 ml of Freund's complete adjuvant was injected intradermally into the right hind foot pad of all rats to induce inflammation. From the second day after the induction of inflammation, the model control group was gavaged with normal saline at a dose of 1.5 mL / 100g (body weight); the high, medium and low dose groups of traditional Chinese medicine preparat...

Embodiment 3

[0047] Example 3. Toxicological study of traditional Chinese medicine preparations for the treatment of ankylosing spondylitis

[0048] According to the "Technical Guidance Principles for Acute Toxicity Research of Traditional Chinese Medicines and Natural Medicines", acute toxicity research was carried out on the traditional Chinese medicine preparation for treating ankylosing spondylitis according to the present invention. The Kunming mice, half male and half female, were randomly divided into two groups: the experimental group and the control group. Fasting for 12 hours before the experiment, the experimental group was given the granule solution prepared in Example 1 according to prescription 3 by gavage at the maximum dose (equivalent to 350.6 g / kg of crude drug, equivalent to 138 times the daily oral dose of an adult). The control group was given an equal volume of normal saline, once in the morning and once in the evening. The body weight, appearance, behavior, excretio...

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Abstract

The invention discloses a traditional Chinese medicinal preparation for treating ankylosing spondylitis. The preparation is prepared from the following raw materials in parts by weight: 196-236 parts of salviae miltiorrhizae, 40-64 parts of pseudo-ginseng, 96-120 parts of Chinese angelica, 140-180 parts of achyranthes root, 196-236 parts of kudzuvine root. The preparation method comprises the following steps: decocting four medicinal materials except pseudo-ginseng, combining decoctions, concentrating at 70 DEG C and reduced pressure to enable the relative density to be 1.36-1.40; adding the pseudo-ginseng, and uniformly mixing to obtain a traditional Chinese medicinal extract; mixing the traditional Chinese medicinal extract and cane sugar powder in a weight ratio of 1: (1-3); adding dextrin which is 0.5-1 time of the weight of the mixture, uniformly mixing, granulating, drying, screening, and drying to obtain granules. The traditional Chinese medicinal preparation is unique in compatibility, simple in preparation method, exact in curative effect and low in toxic and side effect, can remarkably inhibit adjuvant ankle swelling, ear swelling due to croton oil, writhing response caused by acetic acid and cotton ball hyperblastosis, and can be used in clinical treatment of ankylosing spondylitis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine preparation. Background technique [0002] Ankylosing spondylitis (anky losing spondy litis AS) is a systemic chronic progressive immune disease of unknown etiology that mainly invades the axial joint. The pathogenesis may be related to genetics, autoimmune dysfunction, infection and endocrine disorders. After the disease, the patient's self-care ability and work ability will be greatly affected, and it will also bring a heavy burden to the family and society. [0003] Currently, there is no specific and ideal treatment for this disease. There are five main types of drugs for treatment: non-steroidal anti-inflammatory drugs, slow-acting anti-rheumatic drugs, immunosuppressants, glucocorticoids and natural plants; the main treatment mechanisms are anti-inflammatory / anti-inflammatory and analgesic, inhibiting body immunity Functio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P19/08A61P19/02A61P29/00
Inventor 何威邢茂胡雪莲张恩娟雷健李曼
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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