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Puerarin sodium phosphate injection and preparation method thereof

A technology for sodium puerarin phosphate and puerarin phosphate, which is applied in the field of injections whose main drug is sodium puerarin phosphate and its preparation, can solve problems such as instability of puerarin injections

Active Publication Date: 2016-01-20
SHENZHEN XINGYIN PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These phenomena indicate that the puerarin injections on the market are unstable.

Method used

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  • Puerarin sodium phosphate injection and preparation method thereof
  • Puerarin sodium phosphate injection and preparation method thereof
  • Puerarin sodium phosphate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Weigh 100g of sodium puerarin phosphate, 36.0g of sodium chloride, 4.0g of sodium bisulfite, and 8.0g of benzyl alcohol, dissolve completely with 80% water for injection of the prescribed amount, adjust the pH to 6.0 with hydrochloric acid, add 4g of activated carbon, and Adsorb the pyrogen for 30 minutes under stirring, decarburize and filter, and add water for injection to 4000ml. Then it is sterilized and filtered through a 0.22 μm microporous membrane, filled into a 7ml sterilized vial (4ml / bottle), and sealed with a cap.

[0013] 1000 bottles of Puerarin Sodium Phosphate Injection were prepared in this example, and its stability and clinical drug safety were investigated through accelerated tests and animal blood vessel irritation, muscle irritation, hemolysis and anaphylaxis experiments.

[0014] Accelerated test:

[0015] A batch of samples prepared in this embodiment were put into a constant temperature and humidity chamber with a temperature of 40 ± 2°C and a ...

Embodiment 2

Embodiment 3

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PUM

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Abstract

The invention relates to a puerarin sodium phosphate injection and a preparation method thereof. The preparation consists of sodium puerarin phosphate, antiseptic, isotonic regulator, pH regulator, antioxidant, local analgesic and water for injection. The addition of antioxidants can improve the stability of the preparation, and the addition of local analgesics can reduce the pain of patients without affecting the main drug. The preparation process of the preparation mainly includes weighing, dissolving, pyrogen adsorption by activated carbon, filtering, constant volume, terminal filtering, sub-packaging and sealing and capping. The preparation is used for auxiliary treatment of coronary heart disease, angina pectoris, myocardial infarction, retinal artery and vein occlusion, sudden deafness and ischemic cerebrovascular disease, etc. The preparation has stable quality, definite curative effect and is favorable for patients to accept.

Description

technical field [0001] The invention relates to the field of preparations, in particular to an injection whose main drug is puerarin sodium phosphate and a preparation method thereof. Another authorized invention patent of our company, CN10171267.6, has disclosed the structure and preparation method of puerarin sodium phosphate. Background technique [0002] Puerarin is the main active ingredient in the traditional Chinese medicine puerarin, a flavonoid glycoside, chemically named 7,4'-dihydroxy-8-β-D-glucose isoflavone, and the molecular formula is C 21 h 20 o 9 , molecular weight 416.38, CAS number 82373-94-3. Puerarin has the functions of improving immunity, enhancing myocardial contractility, protecting myocardial cells, lowering blood pressure, and anti-platelet aggregation. It is widely used in the treatment of clinical hypertension, coronary heart disease, acute cerebral infarction, diabetes and other diseases. [0003] However, the water solubility of puerarin i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/665A61P9/12A61P9/10A61P3/10
Inventor 姚志勇支钦李新宇舒遂智李云开张建松邱焕杰
Owner SHENZHEN XINGYIN PHARML
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