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A preparation method of Danshi Tongli Tablet and its application in the preparation of drugs for inhibiting the proliferation of ascites tumor cell sac-iic3 cells

A Danshi Tongli Tablet and cell proliferation technology, which is applied in the field of traditional Chinese medicine, can solve the problems of large dosage for patients, rough craftsmanship, and backwardness, and achieve the effect of reducing dosage

Active Publication Date: 2016-04-20
山东源科生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no gallstone tongli capsule that adopts ultrafine pulverization, CO 2 There are reports on supercritical extraction, microwave technology and macroporous resin adsorption technology. However, the traditional Chinese medicine is directly extracted by powdering and decocted in water. The process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. products in clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the extracted frankincense, myrrh residue and other nine herbs are crushed, added with 3.6L of 70% ethanol, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 700W, extraction 2 times, 8 minutes each time, combined...

Embodiment 2

[0034] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for later use; the extracted frankincense, myrrh residue and other nine medicinal materials are crushed, and 3.6L of 70% ethanol is added, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 600W, extraction 2 times, 8 minut...

Embodiment 3

[0037]Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, add to CO2 supercritical extractor, use ethanol as entrainer, and the entrainer accounts for 6% by volume of the total extraction solvent %, extraction pressure 15MPa, temperature 30°C, CO2 flow rate 1ml / g crude drug·min, extraction time 220min, supercritical extract was obtained, and used for later use; extracted frankincense, myrrh residue and other nine herbs were crushed and added to 3.6L Put 70% ethanol into a microwave extraction device for microwave extraction, extraction power 800W, extraction 2 times, 10 minutes each time, combine extracts, concentrate, add to DiaionHP-10 macroporous adsorption resin co...

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Abstract

The invention belongs to the technical field of traditional Chinese medicaments, and in particular relates to a preparation method and application of Danshitongli tablets. The Danshitongli tablets prepared by the preparation method are prepared from 225 g of loosestrife herb, 225 g of oriental wormwood, 90 g of curcuma, 150 g of dried orange peel, 45 g of Baikal skullcap root, 35 g of frankincense, 80 g of mirabilite, 35 g of alum, 45 g of rhubarb, 45 g of rhizoma sparganii, 45 g of gardenia, 25 g of licorice and 35 g of myrrh serving as raw medicinal materials by adopting superfine crushing, supercritical extraction, microwave extraction and macroporous resin adsorption, so that the content of hesperidin is greatly increased. The invention also provides the application of the Danshitongli tablets in preparation of a medicament for suppressing cell proliferation of mouse ascites tumor cells SAC-IIC3.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Danshi Tongli Tablet and its application in the preparation of drugs for inhibiting the proliferation of mouse ascites tumor cells SAC-IIC3 cells. Background technique [0002] The standard number of Danshi Tongli Capsules is WS-10324 (ZD-0324)-2002, which is recorded in the Hepatobiliary Subvolume of the National Compilation of Chinese Patent Standards. Made from 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, and 35g Myrrh. , has the effect of clearing heat and gallbladder, removing blood stasis and removing stones. For acute and chronic cholecystitis and gallstones caused by damp-heat in the liver and gallbladder. [0003] In the prior art, there is no gallstone tongli capsule that adopts ul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/20A61P35/00A61K33/04A61K33/06
Inventor 孙波
Owner 山东源科生物科技股份有限公司
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