Polygala fallax hemsl extract and application thereof in preparation of antitumor drugs

Abstract

The invention discloses a polygala fallax hemsl extract which is prepared according to the following method: carrying out superfine grinding on roots of polygala fallax hemsl into fine powder with theparticle size of 100-200 meshes, then adding the fine powder into fermentation liquor containing a complex microbial inoculant for mixed fermentation, heating and boiling for 10-30 minutes after thefermentation is completed to inactivate microorganisms, and filtering with a 0.22 mu m ceramic membrane, concentrating the filtrate under reduced pressure, and carrying out vacuum freeze drying. A animal testing result shows that the polygala fallax hemsl extract provided by the invention can be used for remarkably prolonging the lifetime of an H22 ascites tumor mouse, also has a remarkable inhibiting effect on a mouse S180 solid tumor, and has an anti-tumor effect superior to that of a conventional water extract and a polysaccharide extract, so that the polygala fallax hemsl extract can be better used for preparing an anti-tumor drug.

Description

technical field [0001] The invention relates to a lotus chrysanthemum extract, and also relates to the use of the extract in preparing antitumor drugs. Background technique [0002] Malignant tumors are complex and difficult to treat clinically. Surgical resection is the first choice for traditional treatment, but only a small number of patients can undergo radical resection. Although chemotherapy is the main method for the treatment of malignant tumors, it has disadvantages such as unsatisfactory curative effect and serious side effects. It is urgent to find a safe and effective treatment for malignant tumors, and it is also a hot research direction at present. Yellow-flowered water lotus (Polygala fallax Hemsl.) is a deciduous shrub or small tree of the genus Polygala of the family Polygala, mainly distributed in Jiangxi, Hunan, Fujian, Yunnan, Guangxi and other regions. It is a common medicine for both medicine and food for the Zhuang, Yao, and Miao nationalities of eth...

AI Technical Summary

Problems solved by technology

[0004] At present, the traditional method of decocting the drug is still used, or the crude drug is crushed and used directly as a medicine. The active ingredients of traditional Chinese medicine cannot be extracted in a targeted manner, resulting in the inability to fully guarantee the curative effect. Decoction under high temperature conditions will also extract a large amount of impurities including heavy metals, etc. , resulting in large doses and side effects, poor compliance, and does not meet the modern natural medicine "three small" (small dose, low toxicity, small side effects), "three effects" (high efficiency, quick-acting, long-acting), "five conveniences" ( The development direction of taking, carrying, production, transportation and storage)

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