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Application of methyl acetophenone in phellinus igniarius to resisting H5N1 avian influenza virus

A kind of technology of methylacetophenone, Pyroporus firewood, applied in the direction of antiviral agent, application, separation/purification of carbonyl compounds, etc.

Inactive Publication Date: 2014-05-28
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Single type, with certain limitations

Method used

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  • Application of methyl acetophenone in phellinus igniarius to resisting H5N1 avian influenza virus
  • Application of methyl acetophenone in phellinus igniarius to resisting H5N1 avian influenza virus

Examples

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Effect test

example 1

[0031] (1) The fermentation medium formula is in grams / 100 milliliters:

[0032] Corn Starch 1% Glucose 1%

[0033] Peptone 0.1% Yeast Extract 0.1%

[0034] Magnesium sulfate 0.1% Potassium dihydrogen phosphate 0.01%

[0035] (2) Inoculate the Phyloporus spp. strains into the Erlenmeyer flask with the liquid medium in a conventional method, with a temperature of 25° C., a shaking flask rotation speed of 110 r / min, and pH 7 conditions, and vibrate for 7 days; cultivate When the pH value drops to 3, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, stir at a temperature of 25°C, a fermenter pressure of 0.1 kg / cm2, a pH of 3, and an air flow of 0.5-1.1vvm. Under the condition of a speed of 100 r / min, after culturing for 7 days, the crude extract of Pheronotus can be prepared by using the whole liquid fermented with the mycelia of Ph.

[0036] (3) Take the fermented whole solution of Phylophorus mycelium obtained in step (2), and concentrate i...

example 2

[0049] (1) The fermentation medium formula is in grams / 100 milliliters:

[0050] Corn Starch 3% Glucose 2%

[0051] Peptone 0.5% Yeast Extract 0.5%

[0052] Magnesium sulfate 0.5% Potassium dihydrogen phosphate 0.05%

[0053] (2) Inoculate the Phylophorus spp. strain into the Erlenmeyer flask with liquid medium in a conventional way, with a temperature of 30° C., a shaker flask rotation speed of 180 r / min, and pH 6 conditions, and vibrate for 15 days; during the cultivation When the pH value drops to 2.5, inoculate the seeds in the shake flask into the culture solution of a 50L fermenter, with a temperature of 30°C, a fermenter pressure of 0.2 kg / cm2, pH 3, an air flow of 0.5-1.1vvm, and a stirring speed Under the condition of 180 rev / min, after culturing for 15 days, the crude extract of Pheronotus can be prepared by using the fermented whole solution of Phyloporea mycelium.

[0054] (3) Take the fermented whole solution of the Phlomophorus mycelium obtained in step (2), a...

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Abstract

The invention discloses methyl acetophenone with an avian influenza-resisting activity, which is separated from fermentation broth and fruiting bodies of phellinus igniarius (LexFr) Quel (phellinus linteus (BerketCurt) Teng, phellinus baumii and phellinus hartigii (AlleschetSchnabl) Imaz). The invention firstly discloses a new activity of methyl acetophenone and proves that the methyl acetophenone has an avian influenza-resisting action. Compared with the application of a general compound, the method has the advantages that the special new activity of methyl acetophenone is found, and the methyl acetophenone has the action of resisting the avian influenza virus; a new idea and a new direction are created for the development and production of drugs for resisting the avian influenza virus.

Description

technical field [0001] The present invention relates to a method for extracting and preparing active substances from Phylonotus spp., which is resistant to avian influenza H5N1 virus, especially the S. General Microbiology Center of the Preservation Management Committee", the deposit number is CGMCC No.8108, the taxonomic name is Phellinus igniarius, and the deposit address is No. 3, No. 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences. Background technique [0002] Acetophenone is a colorless crystal or light yellow oily liquid with the smell of hawthorn, melting point 20.5°C, boiling point 202.3°C, density (20 / 4°C) 1.0281g / cm 3 Slightly soluble in water, easily soluble in a variety of organic solvents, can volatilize with steam, can generate benzoic acid when oxidized; generate ethylbenzene when reduced, and generate ethylcyclohexane when fully hydrogenated, used to make soap and cigarettes It is also used as a solv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P31/16C07C49/825C07C45/78A01G1/04
Inventor 赵晨宋爱荣孔超黄芳孙效乐
Owner QINGDAO AGRI UNIV