Diterpene dimer compounds and pharmaceutical compositions and preparation method and application thereof

Abstract

Diterpene dimer compounds 1-20, pharmaceutical compositions with the compounds as active components, and a preparation method thereof. The preparation method comprises the following steps: taking roots, rhizomes or tubers of lamiaceae plectranthus plants, performing direct cold leaching or thermal reflux extraction with an organic solvent of petroleum ether, n-hexane, chloroform, acetone, methanol, or ethanol, or firstly performing cold leaching or reflux extraction with the organic solvents, then performing extraction with ethyl acetate to obtain total extract, performing repeated chromatography of the total extract to obtain the compounds of the invention. Pharmaceutical compositions with the compounds of the invention as active components can be used for resisting tumor and parasitic diseases. An application of the compounds of the invention in preparation of antitumor agents and anti-parasitic agents comprises: applying the compounds with an amount of 1.6-200 microgram / mL to a substrate or a population, and optionally bonding with carriers and / or media to obtain good cytotoxic activity; applying the compounds with an amount of 0.4-277.8 microgram / mL to a substrate or a population, and optionally bonding with carriers and / or media to obtain good anti-parasitic activity.

Description

Technical field: [0001] The invention belongs to the field of natural medicinal chemistry, and in particular relates to a new class of diterpene dimer compounds, a preparation method thereof, a drug combination with such compounds as active ingredients, and their antitumor and antiparasitic effects. application. technical background: [0002] There are more than 150 species of Isodon or Rabdosia in the Labiatae family. There are 90 species and 21 varieties in my country, almost all over the country, but the most abundant species are in the southwestern provinces, among which 49 species and 15 species are distributed in Yunnan. variants. It has been reported in the literature that the stems and leaves of Camellia are rich in ent-kaurane diterpenoids, which are also the material basis for the biological activities of Camellia, such as antibacterial and antitumor. At the same time, the literature also shows that the underground parts of the plants of the genus Rabdosia Japonic...

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Problems solved by technology

At the same time, the literature also shows that the underground parts of plants of the genus Rabdosia Japonica with abnormal rhizome morphology often have medicinal records, but so far there are few research reports on the underground parts of the plants of the genus, only Rabdosia Japonica (Burm.f.)Hara var.glaucocalyx(Maxim.)Hara]Chemical Composition Research Report

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