Unlock instant, AI-driven research and patent intelligence for your innovation.

Sample applicator sensing and positioning

A sample application and processor technology, applied in the direction of measuring devices, test sample preparation, instruments, etc., can solve problems such as lack of uniformity and hindrance to absolute quantification

Active Publication Date: 2014-06-04
ROCHE DIAGNOSTICS HEMATOLOGY INC
View PDF11 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Additionally, smear preparations are often critical to absolute quantification of sample properties in a given patient due to lack of homogeneity
In general, only relative proportions can be assessed within the smear itself

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sample applicator sensing and positioning
  • Sample applicator sensing and positioning
  • Sample applicator sensing and positioning

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0058] In order to accurately quantify results directly from prepared samples on the substrate, the composition, configuration, and height or thickness of the deposited sample should be as highly uniform as possible across the substrate surface, so that each analytical partition of the sample is also collectively representative of the sample prepared on the substrate. the sample on the bottom, and the patient from whom the sample was taken. In addition, highly consistent and uniformly prepared samples provide a basis for direct comparison of samples and assay results across multiple patient populations. By preparing samples uniformly, automated methods can be used for analysis, significantly increasing throughput.

[0059] A number of different methods can be used to prepare samples in an automated fashion for subsequent analysis. To improve homogeneity, fluid samples of known magnitude (e.g., liquids, suspensions, solutions, and body fluids like human or animal blood or with...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Systems and methods for positioning a sample applicator relative to a substrate include: (a) obtaining an image of the sample applicator in proximity to the substrate, where the image includes a direct image region corresponding to the sample applicator and a first reflected image region corresponding to an image of the sample applicator reflected from a surface of the substrate; (b) determining a position of an edge of the sample applicator in the direct image region; (c) determining a position of a reflected edge of the sample applicator in the first reflected image region; (d) determining a distance between the edge of the sample applicator and the reflected edge of the sample applicator; and (e) determining the position of the sample applicator relative to the substrate based on the distance between the edges.

Description

[0001] Cross reference to related applications [0002] This application claims priority under 35 U.S.C. §119(e) to US Provisional Patent Application No. 61 / 510,728, filed July 22, 2011, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure relates to methods and systems for positioning a sample applicator to dispense a sample on a substrate. Background technique [0004] Traditional methods for analyzing biological samples like blood or body fluids generally involve two steps. First, the automated system performs a qualitative analysis of the sample properties in the liquid state. For example, a sample of blood suspended in a fluid stream is processed using a flow cytometer based on measurements of impedance, fluorescence, and / or scattered light to count red blood cells, white blood cells, platelets, and derive other parameters of a total blood cell count. Second, whenever the flow system detects some abnormality in the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N1/31G01N35/00G01N35/10G01B11/14
CPCG01N1/31G01N35/1011G01N35/00029G01B11/14G06T7/70G06T7/50G06T7/11G06T7/12G06V20/695G01N35/00584G06T2207/30004
Inventor R.扎尼瑟D.扎尼瑟S.康罗伊E.莱克内斯M.扎尼瑟F.波洛斯基
Owner ROCHE DIAGNOSTICS HEMATOLOGY INC