Nonlinear polymer containing doxorubicin structure, and preparation method and application thereof
A doxorubicin and polymer technology, which can be used in medical preparations containing active ingredients, medical preparations without active ingredients, organic active ingredients, etc., can solve the problems of short half-life, low solubility, high toxicity, etc. Prolonged half-life, excellent effect, easy-to-dissolve effect
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Embodiment 1
[0035] 1) The mixture of 80 g of sebacic acid in 800 ml of acetic anhydride is refluxed to form acetyl-sebacic acid;
[0036] 2) Mix the 18g product of step 1) and 8-arm polyethylene glycol ending in a hydroxyl group into a flask, and conduct a solution polymerization reaction under reduced pressure at 180°C for 1 hour; when the polymer is cooled to room temperature, dissolve it with chloroform, and use petroleum washed with ether and dried;
[0037] 3) Put 120mg of doxorubicin and the 800mg polymer of step 2 into 8ml of dimethyl sulfoxide and 12ml of dichloromethane solution for 48 hours; ultrasonic for 3 minutes; then place in an oven for 1 hour; Stir at a high speed in a homogenizer at 20°C for 3 minutes, then put into 1% polyvinyl alcohol solution and stir at 600 rpm for 2 hours; collect by centrifugation and freeze-dry to obtain the nanoparticles of the final product.
Embodiment 2
[0039] 1) The mixture of 100 g of sebacic acid in 900 ml of acetic anhydride is refluxed to form acetyl-sebacic acid;
[0040] 2) Mix the 30 g product of step 1) and 8-arm polyethylene glycol ending in a hydroxyl group into a flask, and conduct a solution polymerization reaction under reduced pressure at 180 ° C for 1 hour; when the polymer is cooled to room temperature, dissolve it with chloroform, and use petroleum washed with ether and dried;
[0041] 3) Put 200mg of doxorubicin and 1000mg of the polymer in step 2 into 6ml of dimethyl sulfoxide and 14ml of dichloromethane solution for 24 hours; ultrasonic for 2 minutes; then put in an oven for 2 hours; at minus 10 degrees Stir in a medium homogenizer at an ultra-high speed for 2 minutes, then put into 10% cholic acid solution and stir at 600 rpm for 3 hours; collect by centrifugation and freeze-dry to obtain the nanoparticles of the final product.
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