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Oral cavity basement membrane and preparation method thereof

A matrix film and oral cavity technology, which is applied in the field of oral matrix film and its preparation to achieve the effects of ensuring product quality, promoting cell reproduction, and simple and easy process.

Active Publication Date: 2014-06-25
广州市弘健生物医用制品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the lack of biodegradable matrix materials in the existing periodontal disease treatment technology, and can not ensure the success of bone grafting treatment. Provided is an oral matrix membrane that has good tissue adhesion, can promote cell proliferation, and can completely biodegrade within a certain period of time, and a preparation method thereof

Method used

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  • Oral cavity basement membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The base material of the oral matrix membrane in this example is a mixture of polylactic acid polymer (PDLLA), acetyl tributyl citrate (ATBC) and L-polylactic acid (PLLA), of which polylactic acid polymer is 77%, acetyl citrate Tributyl is 13%, L-polylactic acid is 10%.

[0023] The molecular weight of polylactic acid polymer is 200,000, and the molecular weight of L-polylactic acid is 50,000 to 80,000. The molecular weight of PDLLA is about 200,000, which is conducive to processing and molding. The effect of adding PLLA is to enhance the physical strength of the film. The degradation time of PLLA is slower than that of PDLLA, so its molecular weight is lower, which is helpful for degradation. The intrinsic viscosity of the final oral matrix membrane substrate is >1.0 dl / g.

[0024] The oral matrix membrane has a three-layer structure, that is, an upper layer 1 , a middle layer 2 and a bottom layer 3 , each layer is provided with a through hole 4 .

[0025] The throug...

Embodiment 2

[0028] The oral matrix membrane in this example is the same as that in Example 1 except that the proportion of base material components is 89.5% of polylactic acid polymer, 10.5% of acetyl tributyl citrate, and 0 of L-polylactic acid.

Embodiment 3

[0030] The oral matrix membrane of this example is the same as that of Example 1 except that the proportion of base material components is 75% of polylactic acid polymer, 13% of acetyl tributyl citrate, and 12% of L-polylactic acid.

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Abstract

The invention provides an oral cavity basement membrane and a preparation method thereof, belonging to the field of medical biodegradable filling material preparation methods. A matrix of the oral cavity basement membrane is formed by mixing 75-89.5% of polylactic acid polymer (PDLLA), 10.5-13% of acetyl tributyl citrate (ATBC) and 0-12% of poly-L-lactic acid (PLLA). The oral cavity basement membrane has a three-layer structure and comprises a top layer (1), a middle layer (2) and a bottom layer (3), wherein through holes (4) are formed in each layer. The defects that existing periodontal disease treatment technology lacks biodegradable matrix materials so that success in bone grafting treatment can not be ensured are overcome by adopting the oral cavity basement membrane and the preparation method. The oral cavity basement membrane provided for people has good tissue adhesion, can promote cell reproduction and can be completely biodegraded in a certain time.

Description

[0001] Technical field: [0002] The invention belongs to the field of preparation methods of medical biodegradable filling materials, and in particular relates to an oral matrix membrane and a preparation method thereof. [0003] Background technique: [0004] Human alveolar bone is the most active bone tissue in the human body, and it tends to absorb throughout life. Once absorbed, the current technology cannot reverse its hyperplasia. Teeth are rooted in the alveolar bone, and the natural resorption of the alveolar bone is the main cause of senile tooth loss and loss of masticatory function. In addition, the destruction of alveolar bone caused by periodontal disease, because there is currently no technical method to promote alveolar bone hyperplasia, in addition to controlling the inflammation of periodontal disease, the only way to allow the alveolar bone to be destroyed is to cause all teeth to fall out. [0005] Although a variety of bone graft materials and bone graf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/26A61L27/50
Inventor 朱晓明
Owner 广州市弘健生物医用制品科技有限公司
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