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Method for preparing aucubin by adopting decoction dregs after extracting chlorogenic acid from folium cortex eucommiae

A technology of aucubin and chlorogenic acid is applied in the field of green chemical technology, which can solve the problems of high equipment cost, poor safety, environmental pollution and the like, and achieve the effects of simple process, product safety and operation safety.

Inactive Publication Date: 2015-05-06
HUNAN WORLD WELLBEING BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, although the above-mentioned extraction, separation and purification method of Eucommia leaf aucubin can prepare Eucommia leaf aucubin extract with a certain purity and yield, due to the limitation of technical means and the use of a large amount of toxic Organic solvents or chemical preparations make the product obviously have defects such as poor safety or low purity and yield, high equipment cost, and insufficient product quality and market competitiveness.
[0009] At present, most of the utilization of eucommia leaves is limited to the extraction and utilization of eucommia chlorogenic acid, and the residual medicine residue after extraction is directly discarded, which not only fails to make full, efficient and reasonable use of eucommia leaf resources, but also causes serious environmental pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Use 8L of edible ethanol with a volume concentration of 40% and a pH of 6 to extract chlorogenic acid from 1 kg of Eucommia leaves, and filter it for 1 hour at 60°C. Concentrate the filtrate at -0.05MPa and 45°C to recover edible ethanol Solvent, vacuum drying at -0.05MPa, 50°C to obtain the crude extract of aucubin. The yield of aucubin was measured to be 57.8%, and the purity was 2.83%.

[0022] The treated NKA-2 macroporous adsorption resin was selected as the resin for separation and purification of aucubin, and the crude extract of aucubin was made into a solution with a concentration of 0.1 mg / mL in distilled water. Pass the 2BV solution at a flow rate of 2.0BV / h through a separation column equipped with NKA-2 macroporous resin for adsorption separation until the adsorption is saturated, then wash it with 1BV of distilled water at a flow rate of 1BV / h until it is colorless, and then use 1.5BV Edible ethanol with a volume concentration of 40% elutes aucubin at a f...

Embodiment 2

[0024] Extract chlorogenic acid from 1kg Eucommia leaves with 10L of edible ethanol with a volume concentration of 60% and a pH of 7, leach at 80°C for 2 hours, then filter, concentrate the filtrate at -0.07MPa and 40°C, and recover edible ethanol Solvent, -0.07MPa, vacuum drying at 55°C to obtain crude aucubin extract. The yield of aucubin was measured to be 59.1%, and the purity was 2.61%.

[0025] The treated NKA-2 macroporous adsorption resin was selected as the separation and purification resin of Eucommia aucubin, and the above-mentioned crude extract of aucubin was prepared into a solution with a concentration of 0.2 mg / mL with distilled water. Pass the 3.0BV solution at a flow rate of 2.0BV / h through a separation column equipped with NKA-2 macroporous resin for adsorption and separation until the adsorption is saturated, then wash it with 2BV of distilled water at a flow rate of 2BV / h until it is colorless, and then use 2.0 Edible ethanol with a BV volume concentratio...

Embodiment 3

[0027] Extract chlorogenic acid from 1 kg of eucommia leaves with 12L of edible ethanol with a volume concentration of 80% and a pH of 8, leach at 100°C for 3 hours, then filter, concentrate the filtrate at -0.09MPa, 50°C, and recover edible ethanol Solvent, -0.09MPa, vacuum drying at 60°C to obtain the crude extract of aucubin. The yield of aucubin was measured to be 63.4%, and the purity was 2.44%.

[0028]The treated NKA-2 macroporous adsorption resin was selected as the separation and purification resin of Eucommia aucubin, and the above-mentioned crude extract of aucubin was prepared into a solution with a concentration of 0.3 mg / mL with distilled water. 3.5BV of the solution is passed through a separation column equipped with NKA-2 macroporous resin at a flow rate of 3.0BV / h for adsorption and separation until the adsorption is saturated, then washed with 3BV of distilled water until colorless at a flow rate of 3BV / h, and then used 2.5BV of edible ethanol with a volume ...

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Abstract

The invention relates to a method for preparing aucubin by adopting decoction dregs after extracting chlorogenic acid from folium cortex eucommiae. The method comprises the steps: extracting an aucubin crude extract from decoction dregs of folium cortex eucommiae after extracting chlorogenic acid by utilizing edible ethanol, and separating and purifying the aucubin crude extract by utilizing NKA-2 macroporous resin to obtain an aucubin extract. According to the method, the aucubin is safely and toxicity-freely extracted and separated by adopting edible ethanol, so that can the aucubin extracts in different purity specifications be safely and effectively produced in an industrialization manner and can the waste be changed into treasure, but also the high-value utilization of safe, simple, reasonable and economical eucommia ulmoides resource and the industrialized production of series products can be actually realized, and the green production concept and strategy of cycling economy can be adequately reflected.

Description

technical field [0001] The invention relates to a green chemical process technology for preparing aucubin from the dregs of eucommia leaves after extracting chlorogenic acid, especially a method of extracting peach leaves from the dregs of eucommia leaves after extracting chlorogenic acid by using edible ethanol The aucubin is then separated and purified by NKA-2 macroporous resin, which is a green separation and purification method for aucubin. Background technique [0002] Eucommia Ulmoides Olive is a plant of the genus Eucommia in the family Eucommia, a deciduous tree. my country has a very wide area suitable for the growth of Eucommia, and the land that can be used to plant Eucommia is more than 10 million hectares. At present, the cultivation area of ​​Eucommia in China is about 350,000 hectares, accounting for more than 99% of the total planting area of ​​Eucommia in the world. It has unique resource advantages. It can produce 4 million tons of leaves. [0003] The ch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04C07H1/08
Inventor 盛达成肖文军刘家波冯林
Owner HUNAN WORLD WELLBEING BIOTECH
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