A kind of compound and its preparation method and application

A compound and chemical technology, applied in the field of medicine, can solve the problems of undiscovered anti-tumor activity, no patent reports, and few reports of Hoparan-type triterpenoids, etc., and achieves obvious inhibitory effect and broad anti-tumor spectrum effect.

Inactive Publication Date: 2016-01-13
SOUTHEAST UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

In recent years, it has been found that many triterpenoids have antitumor activity, but there are relatively few reports on hopane-type triterpenoids
According to literature reports in the past 10 years, only two fernane-type triterpenoids that are similar to hopane-type triterpenoids at positions 2 and 3 were obtained from Alstonia academicis Found in plants [WangF, RenFC, LiuJK. Alstonic acids A and B, unusual2, 3-secofernanetriterpenoids from Alstonia scholaris. Phytochemistry2009;70:650–654], therefore, no reports on the antitumor activity of Hoppane-type triterpenoids with A-ring cracking have been found so far, and no relevant patent reports have been found in the search of the State Intellectual Property Office

Method used

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  • A kind of compound and its preparation method and application
  • A kind of compound and its preparation method and application

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Embodiment 1

[0019] A kind of preparation method of new antitumor compound is as follows:

[0020] (1) Extraction: Firstly, the Latin name of the extract from Cuona County, Tibet Megacodon stylophorus (C.B.Clarke) The whole herb of H.Smith was dried in the shade and weighed about 8.0kg. After the whole herb was crushed, it was soaked and extracted four times with 10 times its weight in 95% ethanol, each time for 7 days. Recover ethanol to obtain 1189g of liquid extract: dissolve the liquid extract in 3000mL of water, extract 3 times with petroleum ether equal to the volume of the extract suspension, combine and concentrate to obtain the petroleum ether extraction fraction (165g).

[0021] (2) Separation and purification: After the petroleum ether extraction part is concentrated under reduced pressure, use 200~300 mesh silica gel to absorb and mix the sample. After evaporating the solvent, place it on a 200~300 mesh silica gel column. First, use petroleum ether:ethyl acetate=10: 8 liters ...

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Abstract

The invention discloses a novel hopane-type triterpene compound with 2 and 3 breaks which is rarely seen in natural products at present, and the molecular formula is C30H48O3. The compound may be derived from the Latin name Megacodon? stylophorus? (C.? B.? Clarke)? H.? Smith's plants. The chemical structure and three-dimensional configuration of the compound were confirmed by the comprehensive analysis of two-dimensional nuclear magnetic resonance spectrum and X-ray diffraction. At the same time, the invention also discloses a preparation method of the compound. In addition, the anti-tumor test in vitro shows that the compound has obvious inhibitory effect on more than ten kinds of tumor cell lines. The invention provides a new lead compound for the development of new antitumor drugs, and is of great significance to the development and utilization of Tibetan medicine resources in my country.

Description

technical field [0001] The invention relates to a compound and its preparation method and application, belonging to the technical field of medicine. Background technique [0002] Cancer threatens human health and life. Among the 6 billion people in the world, about 8 million new cancer patients are added every year, and more than 6 million people die of cancer, almost every 6 seconds. One cancer patient dies. There are more than 80 kinds of anti-tumor drugs commonly used in clinical practice in the world today. Among them, anti-tumor herbal medicines and traditional Chinese medicines for adjuvant chemotherapy mainly include paclitaxel, camptothecin, vinblastine, resveratrol, podophyllotoxin, artemisinin, Ginseng etc. They have definite curative effect and small adverse reactions in tumor treatment, and have become the protagonists in the anti-tumor drug market. With the development of information science and the rise of molecular biology, searching for active ingredients ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J1/00A61P35/00
Inventor 廖志新刘超
Owner SOUTHEAST UNIV
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