34results about How to "Broad anti-tumor spectrum" patented technology

The invention discloses a substituted bismuth thiazolylalkyldithiocarbamate complex and application thereof. Six structural names of the complex are respectively bismuth thiazolylalkyldithiocarbamate, bismuth 2-methylthiazolylalkyldithiocarbamate, bismuth 2-carboxylthiazolylalkyldithiocarbamate, bismuth 2-ethoxycarbonylthiazolylalkyldithiocarbamate, bismuth S-4-carboxylthiazolylalkyldithiocarbamate and bismuth 4-ethoxycarbonylthiazolylalkyldithiocarbamate. The complex can be used for treating in-vivo diseases or symptoms of individuals, wherein the diseases or symptoms can be cancers, including human colon cancer, human mammary cancer, human myeloma, human liver cancer, human lung cancer, human leukaemia and the like. The complex has the advantages of high purity, favorable antitumor effect and broad acting strain spectrum, increases the varieties of the antineoplastic drugs, and has broad market prospects.

The invention discloses a CIK cell, as well as a preparation method and a cell preparation thereof. The method for preparing the CIK cell comprises the following steps: placing a separated mononuclearThe invention discloses a CIK cell, as well as a preparation method and a cell preparation thereof. The method for preparing the CIK cell comprises the following steps: placing a separated mononuclearcell in a culture fluid containing phytohemagglutinin; transplanting the mononuclear cell into a culture flask enveloped by antiCD3 monoclonal antibody and antiCD28 monoclonal antibody after the cell cell in a culture fluid containing phytohemagglutinin; transplanting the mononuclear cell into a culture flask enveloped by antiCD3 monoclonal antibody and antiCD28 monoclonal antibody after the cell is cultured for 24 to 72 hours; and adding a culture fluid containing IL-1alpha and IL-2 into the culture flask to keep on culturing for 5 to 15 days, and separating the cells into different flasks tis cultured for 24 to 72 hours; and adding a culture fluid containing IL-1alpha and IL-2 into the culture flask to keep on culturing for 5 to 15 days, and separating the cells into different flasks to be cultured every 2 to 3 days. The CIK cell prepared by the method has the characteristics of obvious improved cell proliferation, great increase of CD8 cell proportion, wide antineoplastic spectrumo be cultured every 2 to 3 days. The CIK cell prepared by the method has the characteristics of obvious improved cell proliferation, great increase of CD8 cell proportion, wide antineoplastic spectrum and strengthened antineoplastic activity. The CIK cell and the cell preparation can effectively prevent the metastasis and the recrudescence for of postoperative patients with tumor, can be combinedand strengthened antineoplastic activity. The CIK cell and the cell preparation can effectively prevent the metastasis and the recrudescence for of postoperative patients with tumor, can be combinedwith chemicotherapy to effectively reduce toxic and side effects of the chemicotherapy, strengthens the survivability tolerance of the patients to improve healing efficacy, and can obviously prolong lwith chemicotherapy to effectively reduce toxic and side effects of the chemicotherapy, strengthens the survivability tolerance of the patients to improve healing efficacy, and can obviously prolong lifecycle to of end-stage patients so as to improve the life living quality.ifecycle to of end-stage patients so as to improve the life living quality.

The invention discloses a novel hopane-type triterpene compound with 2 and 3 breaks which is rarely seen in natural products at present, and the molecular formula is C30H48O3. The compound may be derived from the Latin name Megacodon? stylophorus? (C.? B.? Clarke)? H.? Smith's plants. The chemical structure and three-dimensional configuration of the compound were confirmed by the comprehensive analysis of two-dimensional nuclear magnetic resonance spectrum and X-ray diffraction. At the same time, the invention also discloses a preparation method of the compound. In addition, the anti-tumor test in vitro shows that the compound has obvious inhibitory effect on more than ten kinds of tumor cell lines. The invention provides a new lead compound for the development of new antitumor drugs, and is of great significance to the development and utilization of Tibetan medicine resources in my country.