Use of 2-alkyl substituted 4,6-diamino-1,3-5-triazine derivate

A technology of hydrocarbyl substitution and diamino, applied in the application field of 2-hydrocarbyl substitution of 4,6-diamino-1,3,5-triazine derivatives

Inactive Publication Date: 2008-11-19
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hexamethylmelamine is an effective drug against breast cancer, lung cancer and ovarian cancer, but its severe side effects such as nausea, vomiting, abdominal cramps and anorexia limit its clinical application [Cancer Treat.Rev., 1986, 13, 197-217]

Method used

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  • Use of 2-alkyl substituted 4,6-diamino-1,3-5-triazine derivate
  • Use of 2-alkyl substituted 4,6-diamino-1,3-5-triazine derivate
  • Use of 2-alkyl substituted 4,6-diamino-1,3-5-triazine derivate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] Example: In vitro inhibitory effect of 2-hydrocarbyl substituted 4,6-diamino-1,3,5-triazine derivatives on different tumor cells

[0016] (1) Experimental materials

[0017] Cell lines: human lung cancer A549 cells, human leukemia K562 cells, human prostate cancer PC-3 cells, human ovarian cancer HO8910 cells and human breast cancer MCF-7 cells.

[0018] Medium: RPMI 1640 medium, containing 10% calf serum.

[0019] Drug and preparation: The drug is the 2-hydrocarbyl substituted 4,6-diamino-1,3,5-triazine derivative synthesized above dissolved in dimethyl sulfoxide (DMSO). Compound structures are shown in Table 1. The positive control drug was doxorubicin.

[0020] (2) Experimental method

[0021] The above-mentioned tumor cells in the logarithmic growth phase were divided into 5×10 3 Seed in a 96-well plate at a density of 96 wells, add 200 μl of cell suspension to each well, and add 5 concentrations of 2-hydrocarbyl-substituted 4,6-diamino-1,3,5-triazines after 24...

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Abstract

The invention provides the application of 2-alkyl substitution4, 6-diamino-1, 3, 5-triazine derivatives to the preparation of anti-neoplastic drugs. Research shows that the 2-alkyl substitution4, 6-diamino-1, 3, 5-triazine derivatives have the proliferation inhibiting action on multiple cancer cell strains, more particularly have obvious inhibition action on multiple tumor cell strains such as human lung cancer A549 cells, human leukemia K562 cells, human prostatic cancer PC-3 cells, human ovarian cancer HO8910 cells, human breast cancer MCF-7 cells, etc., and the antitumor spectra is wider.

Description

technical field [0001] The invention belongs to the medical use of compounds, and mainly relates to the anti-proliferation effect of triazine derivatives on various tumor cancer cell lines and their application in the preparation of antitumor drugs. Background technique [0002] With the influence of various factors such as environmental pollution, the incidence of tumor continues to rise, and the mortality rate of patients is increasing day by day. Therefore, governments, research institutes and pharmaceutical companies of various countries have long attached great importance to tumor research and anti-tumor drugs. At present, chemotherapy is the main method for treating tumors, but many antitumor drugs have disadvantages such as poor selectivity, low efficiency, immunosuppression, and drug resistance, and the therapeutic effect is not ideal. Therefore, new compounds with anti-tumor potential have become the focus and focus of medicinal chemistry research and development. ...

Claims

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Application Information

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IPC IPC(8): A61K31/53A61P35/00
Inventor 胡章陈哲叶子奇羊红玉楼宜嘉俞永平
Owner ZHEJIANG UNIV
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