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F3 polypeptide-targeted nanoorganometallic framework materials (nmofs) and preparation methods thereof

A metal frame material and nano-organic technology, applied in the field of biopolymer materials and nanometers, can solve the problems of strong non-specific adsorption, low cell entry efficiency, and large side effects, and achieve strong membrane penetration, extended long cycle, and drug loading high volume effect

Active Publication Date: 2021-01-19
WUHAN UNIV OF TECH
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Problems solved by technology

[0002] Many drug molecules have poor water solubility, strong non-specific adsorption, low cell entry efficiency and large side effects, which limit their application in the field of biomedicine.

Method used

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  • F3 polypeptide-targeted nanoorganometallic framework materials (nmofs) and preparation methods thereof
  • F3 polypeptide-targeted nanoorganometallic framework materials (nmofs) and preparation methods thereof
  • F3 polypeptide-targeted nanoorganometallic framework materials (nmofs) and preparation methods thereof

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Embodiment Construction

[0043] Specific embodiments of the present invention are described in detail below, which, as a part of the description, illustrate the principle of the present invention through examples, and other aspects, features and advantages of the present invention will become clear through the detailed description.

[0044] Materials and reagents: Dimethyl 2-aminoterephthalate was purchased from Energy Chemicals (Shanghai, China). 37% HCl, sodium nitrite, potassium hydroxide, sodium azide, tetrahydrofuran, anhydrous copper sulfate, triethylamine (TEA) and dimethylformamide (DMF) were purchased from Sinopharm Chemical Reagent Co., Ltd. (Beijing, China) without further purification. Zirconium chloride octahydrate and sodium ascorbate were ordered from Aladdin (Shanghai, China); doxorubicin hydrochloride (DOX HCl) was obtained from Beijing Huafeng United Technology Company (Beijing, China); MAL-PEG-Alkyne and mPEG-Alkyne Purchased from Toyongbio (Shanghai, China). F3 polypeptide (MW: 353...

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Abstract

The invention discloses an F3 polypeptide targeted nano organic metal frame material (nMOFs) and a preparation method thereof. A transition element Zr and an organic ligand BDC-N3 are synthesized intoa nano-carrier UIO-66-N3, and then two PEGs of which the tail ends are modified by alkynyl are loaded on the surface of the UIO-66-N3 through a click chemical reaction, thereby avoiding the aggregation between nanoparticles, and increasing the long circulation effect of the nanoparticles; then an F3 polypeptide is conjugated on the surface of the UIO-66-N3 to give the UIO-66-N3 targeting. In thewhole chemical transformation process, the structure of a framework of the UIO-66-N3 is retained and loaded with DOX to prepare a fluorescent imaging agent for treatment, and the nanoparticles of thesynthesized DOX / UIO-66-PEG-F3 have the effects of treatment and targeting. The F3 polypeptide targeted nano organic metal frame material (nMOFs) has potential clinical application value, and providesmore powerful technical support for the treatment of malignant tumors.

Description

technical field [0001] The invention relates to the technical field of biopolymer materials and nanotechnology, in particular to a nano-organometallic framework material (nMOFs) targeting tumors and environmental pH stimulus-responsive drug-controlled release nanocarrier F3 polypeptides (nMOFs) and its preparation method. Background technique [0002] Many drug molecules have defects such as poor water solubility, strong non-specific adsorption, low cell entry efficiency and large side effects, which limit their application in the field of biomedicine. Therefore, how to selectively deliver drugs to diseased tissues or cells in the body to improve their diagnostic or therapeutic effects has always been a long-term goal in the field of biomedicine. The use of nanocarriers to load probes or drug molecules and deliver them to target sites can not only effectively overcome the above-mentioned defects of drugs or imaging probe molecules, but also prevent them from being rapidly m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/51A61K47/22A61K47/42A61K47/10A61K31/704A61P35/00A61K49/00C08G83/00
Inventor 徐文瑨肖金玲张超方雪婷蔡莎莉李勇宗琦曾雅文
Owner WUHAN UNIV OF TECH
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