Compound as well as preparation method and application thereof

A compound and chemical technology, applied in the field of medicine, can solve the problems of undiscovered anti-tumor activity, undisclosed patent reports, and few reports of hopane-type triterpenoids, etc., and achieve the effect of broad anti-tumor spectrum and obvious inhibitory effect

Inactive Publication Date: 2014-08-13
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, it has been found that many triterpenoids have antitumor activity, but there are relatively few reports on hopane-type triterpenoids
According to the literature reports in the past 10 years, only two 2,3-cracked fern-type triterpenoids similar to hopane-type triterpenoids were found from Alstonia scholaris plants [Wang F, Ren FC, Liu JK. Alstonic acids A and B, unusual 2,3-secofernane triterpenoids from Alstonia scholaris. Phytochemistry 2009; 70: 650–654], therefore, the No report on the antitumor activity of Hoppane-type triterpenoids has been found so far, and no relevant patent reports have been found in the search of the State Intellectual Property Office

Method used

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  • Compound as well as preparation method and application thereof
  • Compound as well as preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0019] A kind of preparation method of new antitumor compound is as follows:

[0020] (1) Extraction: Firstly, the Latin-named Megacodon stylophorus (C. B. Clarke) The whole plant of H. Smith was dried in the shade, weighing about 8.0 kg. After the whole plant was crushed, it was soaked and extracted four times with 95% ethanol 10 times its weight, each time for 7 days. Recover ethanol to obtain 1189 g of liquid extract: dissolve the liquid extract in 3000 mL of water, extract 3 times with petroleum ether equal to the volume of the extract suspension, combine and concentrate to obtain the petroleum ether extract (165 g).

[0021] (2) Separation and purification: After the petroleum ether extraction part is concentrated under reduced pressure, use 200~300 mesh silica gel to absorb and mix the sample. After evaporating the solvent, place it on a 200~300 mesh silica gel column. First, use petroleum ether:ethyl acetate=10: 8 liters were eluted with an eluent with a volume ratio...

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Abstract

The invention discloses a novel hopane type triterpene compound which is rare in natural products at present has fracture at 2 and 3 positions and has the molecule formula of C30H48O3. The compound can be obtained from a plant of which the Latin name is Megacodonstylophorus (C.B.Clarke) H.Smith. Comprehensive analysis of two-dimension nuclear magnetic resonance spectrum and X-ray diffraction confirms the chemical structure and the spatial configuration of the compound. The invention further discloses a preparation method of the compound. In addition, the in-vitro anti-tumor experiment shows that the compound has a remarkable inhibition function on dozens of tumor cell stains. The compound provides a novel lead compound for researching novel anti-tumor medicines, and is significant for Tibetan medicine resource development and utilization.

Description

technical field [0001] The invention relates to a compound and its preparation method and application, belonging to the technical field of medicine. Background technique [0002] Cancer threatens human health and life. Among the 6 billion people in the world, about 8 million new cancer patients are added every year, and more than 6 million people die of cancer, almost every 6 seconds. One cancer patient dies. There are more than 80 kinds of anti-tumor drugs commonly used in clinical practice in the world today. Among them, anti-tumor herbal medicines and traditional Chinese medicines for adjuvant chemotherapy mainly include paclitaxel, camptothecin, vinblastine, resveratrol, podophyllotoxin, artemisinin, Ginseng etc. They have definite curative effect and small adverse reactions in tumor treatment, and have become the protagonists in the anti-tumor drug market. With the development of information science and the rise of molecular biology, searching for active ingredients ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J1/00A61P35/00
Inventor 廖志新刘超
Owner SOUTHEAST UNIV
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