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Medicament for treating damp-heat spreading type motor neuron diseases and preparation method thereof

A technology for motor neuron disease and external use of drugs, applied in the field of pharmacy, can solve problems such as immaturity, and achieve the effects of not easy recurrence, high safety, and no toxic side effects

Inactive Publication Date: 2014-08-27
陈龙霏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, some new treatments such as stem cell transplantation and gene therapy are still in the research stage and are not yet mature for clinical use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0078] The dosage form of described internal medicine is tablet, and its preparation method comprises the following steps:

[0079] The first step is to mix the raw materials of the traditional Chinese medicine in proportion, add ethanol with an alcohol concentration of 85-95% 2-4 times the mass of the mixture, heat and reflux for 1-3 hours, extract, and filter to obtain the first extract ; The medicinal residue obtained by filtering is then added with ethanol with an alcohol concentration of 85-95% relative to the quality of the medicinal residue 1-2 times, heated and refluxed for 1-3 hours, extracted, and filtered to obtain the second extract; the first extracted The liquid and the second extract are combined, concentrated under reduced pressure to remove the ethanol solvent, and dried to obtain a dry paste;

[0080] In the second step, the dry paste obtained in the first step is placed in an ultrafine pulverizer for 1 to 2 hours, pulverized, and sieved to obtain an ultrafin...

Embodiment 1

[0089] Example 1 tablet

[0090] The embodiment of the present invention provides a kind of medicine that is used for the treatment of damp-heat immersion type motor neuron disease, and its dosage form is a tablet, and the parts by weight of its raw materials are: phellodendron 18 parts by weight, bark bark 15 parts by weight, horsetail root 15 parts by weight, 15 parts by weight of Andrographis paniculata, 15 parts by weight of Lulu, 21 parts by weight of canna, 15 parts by weight of curculigo, 14 parts by weight of Hualuomo, 15 parts by weight of Jiaogulan, 20 parts by weight of Patrinia, Hedyotis diffusa 14 parts by weight, 12 parts by weight of brocade lanterns, 14 parts by weight of Persica barbadensis, 24 parts by weight of Qumai, 14 parts by weight of Heliconia chinensis, 21 parts by weight of Ganoderma lucidum, 23 parts by weight of Mori twigs, 21 parts by weight of scorpion vine, 24 parts by weight of geranium Parts, 12 parts by weight of Chuanshanlong, 12 parts by we...

Embodiment 2

[0096] Example 2 Umbilical patch

[0097] The embodiment of the present invention provides a kind of medicine that is used for the treatment of damp-heat soaking type motor neuron disease, and its dosage form is umbilical patch, and the parts by weight of each raw medicinal material of it is: Radix Astragali 15 parts by weight, Salvia miltiorrhiza 15 parts by weight, Cortex chinensis 12 parts by weight, 15 parts by weight of fennel, 13 parts by weight of loofah, 12 parts by weight of cinnamon and 15 parts by weight of longan.

[0098] Its preparation method comprises the following steps:

[0099]In the first step, the raw medicinal materials are mixed in proportion, crushed into 50-mesh powder, and ethanol with an alcohol concentration of 90% that is three times the mass of the mixture is added, heated and refluxed for 2 hours, extracted, and filtered to obtain the first extract; The medicinal residue obtained by filtering is then added with ethanol with an alcohol concentrat...

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PUM

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Abstract

The invention discloses a medicament for treating damp-heat spreading type motor neuron diseases and a preparation method thereof. The medicament is prepared from internal medicinal materials and external medicinal materials, wherein the internal medicinal materials comprise the following raw medicinal materials: cortex phellodendri, ash bark, meadowrue root and rhizome, herba andrographitis, uniflower swisscentaury root, canna, white-stemmed scorzonera root, metaplexis hemsleyana, gynostemma pentaphylla, dahurian patrinia herb, oldenlandia diffusa, physalis permviana, cortex periplocae, fringed pink, yam rhizome, lucid ganoderma, mulberry twig, Chinese starjasmine stem, erodium stephanianum willd, rhizoma dioscoreae nipponicae, loofah sponge, mistletoe, ligusticum wallichii, turmeric, trogopterus dung, Chinese trumpet creeper, artemisia anomala, radix achyranthis bidentatae and zygophyllum fabago; the external medicinal materials comprise the following raw medicinal materials: astragalus membranaceus, salviae miltiorrhizae, ash bark, fennel, loofah sponge, cinnamon and longan pulp. The medicament has the beneficial effects that the medicament is mainly used for clearing heat and drying dampness as well as promoting tendons and vessels, and has the advantages of good curative effect, high safety, no toxic or side effect and relapse prevention when being used for treating damp-heat spreading type motor neuron diseases.

Description

[0001] technical field [0002] The invention relates to the technical field of pharmacy, in particular to a medicine for treating damp-heat immersion type motor neuron disease and a preparation method thereof. [0003] Background technique [0004] Motor neuron disease is a group of chronic progressive degenerative diseases that mainly damage the anterior horn of the spinal cord, bridging cranial nerve motor nuclei and pyramidal tracts. Symptoms such as muscle atrophy and muscle weakness are the most common, such as slurred speech, difficulty swallowing, difficulty moving, and difficulty breathing. Finally, the patient died of inability to breathe while conscious. So this kind of patient is also called "gradually frozen person". [0005] The etiology and pathogenesis are unclear, and 5% to 10% of patients have a family history, which is called familial motor neuron disease. In recent years, peroxides have been found in this group of patients with motor neuron disease wit...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K36/77A61P25/00A61P25/28A61K35/24
Inventor 陈龙霏张宪忠
Owner 陈龙霏
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