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TGF-r antisense sequence and its application in the preparation of anti-airway inflammatory response medicine

A technology of TGF-R and antisense sequence, which is applied in the application field of preparing anti-airway inflammatory response drugs, can solve the problem of lack of TGF-R antisense sequence and the like, and achieve the effect of inhibiting airway inflammation

Inactive Publication Date: 2016-03-30
NANJING CHILDRENS HOSPITAL AFFILIATED TO NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports of highly efficient TGF-R antisense sequences

Method used

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  • TGF-r antisense sequence and its application in the preparation of anti-airway inflammatory response medicine
  • TGF-r antisense sequence and its application in the preparation of anti-airway inflammatory response medicine
  • TGF-r antisense sequence and its application in the preparation of anti-airway inflammatory response medicine

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Experimental program
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Effect test

Embodiment 1

[0021] 1. Obtaining TGF-R antisense sequence

[0022] Use RNAstructure software to select the unstable site in TGF-R mRNA (GenBank: NC_000070.6). Predict the target site for the unstable region of TGF-R, and avoid: four consecutive Gs; more than six palindromic structures.

[0023] The TGF-R antisense sequence is SEQ5'-AGCAGCCCCCGACCCATGGC-3' (SEQ ID NO.1).

[0024] 2. Synthesis of TGF-R antisense sequence

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Abstract

The invention belongs to the fields of genetic engineering and pharmacy, and discloses a TGF-R (Transforming Growth Factor-Receptor) antisense sequence and an application thereof in preparing a medicament for preventing airway inflammation reaction. The nucleotide sequence of the TGF-R antisense sequence is as shown in SEQ ID NO.1. Due to adoption of the antisense sequence, the airway inflammatory cell infiltration is remarkably alleviated, and thus the TGF-R antisense sequence can be applied to preparation of medicaments for preventing airway inflammation reaction.

Description

technical field [0001] The invention belongs to the field of genetic engineering and pharmacy, and relates to a TGF-R antisense sequence and its application in the preparation of anti-airway inflammation medicine. Background technique [0002] Asthma is a common childhood chronic disease, and its prevalence has shown a significant upward trend in recent years. In 1990, the prevalence rate of bronchial asthma in Chinese children was 0.91%, and it rose to 1.5% in 2000. According to the World Health Organization, there are currently 300 million people in the world suffering from bronchial asthma. In 2005, the number of deaths from bronchial asthma in the world was about 255,000, 80% of which occurred in developing countries. The economic burden brought by bronchial asthma has exceeded the sum of tuberculosis and AIDS. Therefore, further research on the pathogenesis of bronchial asthma has an urgent realistic demand. [0003] TGF-β signaling pathway is one of the key signali...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N15/113A61K48/00A61P11/06A61P11/00
Inventor 赵德育刘峰田曼唐珩雷其洪王全秦厚兵
Owner NANJING CHILDRENS HOSPITAL AFFILIATED TO NANJING MEDICAL UNIV
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