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A kind of method for preparing acyclovir tablet

A technology for oral tablets and prescriptions, which is applied in the field of acyclovir tablets and its preparation, can solve the problems of short time and cannot be used as an evaluation index to evaluate drug stability, so as to ensure dissolution, superior stability, and safety sexual effect

Active Publication Date: 2017-01-04
LIVZON PHARM GRP INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] CN103462917B discloses a preparation method of acyclovir tablet, which overcomes the dissolution rate problem of acyclovir tablet
However, in the article's experiment, the stability test of acyclovir tablets lasted only 6 months, which was too short to be used as an evaluation index to evaluate the stability of the drug after it went on the market.

Method used

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  • A kind of method for preparing acyclovir tablet
  • A kind of method for preparing acyclovir tablet
  • A kind of method for preparing acyclovir tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015]

[0016]

[0017] The preparation process is as follows: using the wet granulation process to compress tablets, taking acyclovir, mannitol, maltodextrin, pregelatinized starch, magnesium stearate, and sodium carboxymethyl starch in sequence, and mixing them in equal increments. Half of the prescription amount of low-substituted hydroxypropyl cellulose aqueous solution is made into a soft material, sieved and granulated, and air-dried at 80°C. After sieving and granulating, add the remaining low-substituted hydroxypropyl cellulose, lactose, hydroxyl Propyl methyl cellulose and calcium sulfate are uniformly mixed and pressed into tablets.

Embodiment 2

[0019]

[0020] The preparation process is as follows: using the wet granulation process to compress tablets, taking acyclovir, mannitol, maltodextrin, pregelatinized starch, magnesium stearate, and sodium carboxymethyl starch in sequence, and mixing them in equal increments. Half of the prescription amount of low-substituted hydroxypropyl cellulose aqueous solution is made into a soft material, sieved and granulated, and air-dried at 80°C. After sieving and granulating, add the remaining low-substituted hydroxypropyl cellulose, lactose, hydroxyl Propyl methyl cellulose and calcium sulfate are uniformly mixed and pressed into tablets.

Embodiment 3

[0022]

[0023]

[0024] The preparation process is as follows: using the wet granulation process to compress tablets, taking acyclovir, mannitol, maltodextrin, pregelatinized starch, magnesium stearate, and sodium carboxymethyl starch in sequence, and mixing them in equal increments. Half of the prescription amount of low-substituted hydroxypropyl cellulose aqueous solution is made into a soft material, sieved and granulated, and air-dried at 80°C. After sieving and granulating, add the remaining low-substituted hydroxypropyl cellulose, lactose, hydroxyl Propyl methyl cellulose and calcium sulfate are uniformly mixed and pressed into tablets.

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Abstract

The present invention relates to a long-term stable acyclovir oral tablet. A technical scheme is as follows: 800-150 parts of acyclovir, 30-50 parts of mannitol, 15-30 parts of maltodextrin, 15-30 parts of pregelatinized starch, 10 parts of sodium carboxymethyl starch, 10 parts of magnesium stearate, 25-40 parts of low substitution hydroxypropyl cellulose, 10 parts of lactose, 2-3 parts of calcium sulfate and 5 parts of hydroxypropyl methyl cellulose.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an acyclovir tablet and a preparation method thereof. Background technique [0002] Aciclovir (Aciclovir) is a DNA-inhibiting antiviral drug. It is mainly used clinically for hepatitis B and skin and mucous membrane infections caused by chickenpox, shingles, and herpes simplex virus. It has become a major drug sold worldwide. one. The drug is slightly soluble in glacial acetic acid or hot water, but practically insoluble in ether or dichloromethane. [0003] CN101804037A discloses an acyclovir dispersible tablet and a preparation method thereof. Since aciclovir is very slightly soluble in water, this technology produces a dispersible tablet with a shortened disintegration time. [0004] CN103462917B discloses a preparation method of acyclovir tablet, which overcomes the dissolution rate problem of acyclovir tablet. [0005] But above-mentioned ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/522A61P31/20A61K47/38
Inventor 孔祥生金鑫吴起娟周禹
Owner LIVZON PHARM GRP INC
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