Application of ERBB2 protein in preparation of reagent for detecting pheochromocytoma metastasis

Abstract

The invention belongs to the field of biological medicines, and particularly relates to application of ERBB2 protein in preparation of a reagent for detecting pheochromocytoma metastasis. 262 patients suffering from pheochromocytoma, confirmed through operations and pathology, are selected, and the pheochromocytoma metastasis is not found in the patients when the patients are hospitalized. Basic clinical data of the patients are collected, such as genders, ages, clinical manifestations, biochemical detection results, pathological results, imaging data and pathology results. Experimental results show that the high expression of the ERBB2 protein in cases of pheochromocytoma metastasis is achieved, so that the close relationship exists between the ERBB2 protein and the pheochromocytoma metastasis. The invention verifies that the pheochromocytoma metastasis has a close relationship with the ERBB2 protein expression, and the pheochromocytoma metastasis is confirmed rapidly and accurately by detection on ERBB2. The invention provides experimental data and a theoretical basis for clinic application of the ERBB2 protein in the detection on the pheochromocytoma metastasis.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of ERBB2 protein in the preparation of reagents for detecting pheochromocytoma metastasis. Background technique [0002] Pheochromocytoma (PCC) is a pheochromocytoma originating from the adrenal medulla. Pheochromocytoma can synthesize, store, metabolize and secrete catecholamine hormones, which can cause paroxysmal hypertension and typical- Triple symptoms of headache, palpitations, and sweating. [0003] The incidence of malignant pheochromocytoma is about 10%. From the perspective of clinical manifestations of patients, there is no particularly obvious difference between malignant pheochromocytoma patients and benign patients. Malignant pheochromocytomas are defined as chromaffin metastases in non-chromaffin tissues of distant organs, excluding adjacent invasion. This definition specifies that metastases must occur where chromaffin tissue does not exist ...

AI Technical Summary

Problems solved by technology

However, the occurrence and development of tumors is a multi-factor and multi-stage process, and a single molecular marker is theoretically difficult to be competent for the differential diagnosis of benign and malignant pheochromocytomas.

In the study of other malignant tumors, it was also found that the expression of a certain molecular marker cannot completely predict the metastasis

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