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Method for rapid imaging of biologic fluid samples

A technology for biological fluids and samples, used in biological testing, fluid controllers, laboratory containers, etc., and can solve problems such as limited high-resolution imaging

Inactive Publication Date: 2014-10-01
ABBOTT POINT CARE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the speed of operation of automated devices can be significantly limited by high-resolution imaging

Method used

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  • Method for rapid imaging of biologic fluid samples
  • Method for rapid imaging of biologic fluid samples
  • Method for rapid imaging of biologic fluid samples

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Experimental program
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Embodiment Construction

[0017] refer to figure 1 and Figure 5 , the present invention includes methods and apparatus for analyzing a biological fluid sample (eg, whole blood) quiescently residing in an analysis chamber 10 configured to allow analysis device 12 to automatically analyze the sample. The sample residing stationary within the chamber 10 is imaged and the image of the sample is analyzed by means of an analysis device 12 .

[0018] Figure 1 to Figure 4 A schematic diagram of a cavity 10 that may be used with the present invention is shown in . Chamber 10 is formed from a first planar member 14 and a second planar member 16 and generally has at least three barriers 18 disposed between planar members 14 and 16 . At least one of planar member 14 and planar member 16 is transparent. The height 20 of the chamber 10 is generally such that a sample residing within the chamber 10 will travel laterally within the chamber 10 by capillary forces. Figure 4 A cross-section of cavity 10 is shown,...

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Abstract

A method for analyzing a biologic fluid sample is provided. The method includes the steps of: a) disposing the biologic fluid sample within a chamber; b) imaging the biologic fluid sample at a first resolution, and producing first image signals representative of a low resolution image of the sample; c) analyzing the first image signals to identify one or more first characteristics of the sample, and determining a position of each first characteristic within the chamber using a map of the chamber; d) imaging a portion of the biologic fluid sample at a second resolution and producing second image signals, which portion of the sample is determined using the first characteristics and the map, and wherein the second resolution is greater than the first resolution; and e) analyzing the biologic fluid sample using the second image signals.

Description

[0001] This application claims the benefit of the substantial subject matter disclosed in U.S. Provisional Patent Application No. 61 / 581,851, filed December 30, 2011, and U.S. Provisional Patent Application No. 61 / 594,136, filed February 2, 2012 and which essentially The subject matter is incorporated herein by reference. technical field [0002] The present invention relates generally to methods for imaging biological fluid samples, and more particularly to methods and apparatus for imaging biological fluid samples at more than one resolution, and in some cases less than the entire sample. Background technique [0003] Previously, biological fluid samples (such as whole blood, urine, cerebrospinal fluid, body cavity fluid, etc.) have been assessed for their granular content by smearing a small amount of undiluted fluid on a glass slide and evaluating the smear under a manually operated microscope matter or cell contents. Reasonable results can be obtained using these techn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00G01N15/14G02B21/36G06K9/00
CPCB01L3/5027B01L3/508G01N2015/1486B01L2200/0689B01L2400/0406G01N15/1475B01L9/52G01N33/49B01L2300/0822B01L9/56
Inventor 敏·A·谢大卫·赫尔佐格约翰·维尔兰特
Owner ABBOTT POINT CARE