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Composition for treating oral mucositis, as well as preparation method and application package thereof

A technology for oral mucositis and a composition, applied in the field of medicine, can solve the problems of single therapeutic effect, inconvenient administration, large side effects, etc., and achieve the effects of simple process, definite clinical efficacy and stable properties

Inactive Publication Date: 2014-12-03
左克源 +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Baking soda solution or concentrated normal saline is commonly used clinically at present to gargle, and the therapeutic effect is single and the effect is very poor; For patients with pain caused by oral mucositis, opioid analgesics or local anesthetic gel are given to the whole body, and the side effects are large and cause severe pain. Medicine is extremely inconvenient

Method used

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  • Composition for treating oral mucositis, as well as preparation method and application package thereof
  • Composition for treating oral mucositis, as well as preparation method and application package thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Mix 96 mg of hydroxyethyl cellulose, 24 mg of hydroxypropyl cellulose and 60 mg of simethicone, heat to 45°C, add 20 ml of warm purified water while stirring, and mix well, then add 600 mg of aluminum hydroxide and 600 mg of magnesium hydroxide , Stir evenly to obtain a suspension. Then, 60 mg of sorbitol, 60 mg of mannitol, 60 mg of butyl p-hydroxybenzoate and 40 ml of purified water were added to the suspension, stirred uniformly, and adjusted to pH 6.5 with acetic acid to obtain a suspension of aluminum hydroxide and magnesium hydroxide. Then, 30 mg of ropivacaine mesylate was added to the aluminum hydroxide and magnesium hydroxide suspension, and the mixture was stirred uniformly to obtain a suspension for treating oral mucositis.

[0026] An application package composed of the composition for treating oral mucositis of the present embodiment, which includes a bottle of aluminum hydroxide magnesium hydroxide suspension and a bottle of 30 mg ropivacaine mesylate. Among...

Embodiment 2

[0028] Mix 156 mg of hydroxyethyl cellulose, 84 mg of hydroxypropyl cellulose and 120 mg of simethicone, heat to 50°C, add 25 ml of warm purified water while stirring, and mix well, then add 800 mg of aluminum hydroxide and 700 mg of magnesium hydroxide , Stir evenly to obtain a suspension. Then, 120 mg of sorbitol, 120 mg of mannitol, 120 mg of butyl p-hydroxybenzoate and 35 ml of purified water were added to the suspension, stirred uniformly, and adjusted to pH 7 with acetic acid to obtain a suspension of aluminum hydroxide and magnesium hydroxide. Then, 90 mg of ropivacaine mesylate was added to the aluminum hydroxide and magnesium hydroxide suspension, and the mixture was stirred uniformly to obtain a suspension for treating oral mucositis.

[0029] An application package composed of the composition for treating oral mucositis of the present embodiment, which includes a bottle of aluminum hydroxide magnesium hydroxide suspension and a bottle of 90 mg ropivacaine mesylate. Am...

Embodiment 3

[0031] Mix 180mg of hydroxyethyl cellulose, 180mg of hydroxypropyl cellulose and 180mg of simethicone, heat to 48℃, add 30ml of warm purified water while stirring, and mix well, then add 1000mg of aluminum hydroxide and 1100mg of magnesium hydroxide , Stir evenly to obtain a suspension. Then, 180 mg of sorbitol, 180 mg of mannitol, 180 mg of butyl p-hydroxybenzoate and 30 ml of purified water were added to the suspension, stirred uniformly, and adjusted to pH 7.5 with acetic acid to obtain a suspension of aluminum hydroxide and magnesium hydroxide. Then, 165 mg of ropivacaine mesylate was added to the aluminum hydroxide and magnesium hydroxide suspension, and the mixture was stirred uniformly to obtain a suspension for treating oral mucositis.

[0032] An application package composed of the composition for treating oral mucositis of the present embodiment, which includes a bottle of aluminum hydroxide and magnesium hydroxide suspension and a bottle of 165 mg of ropivacaine mesyla...

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Abstract

The invention discloses a composition for treating oral mucositis. The composition is prepared from ropivacaine mesylate and an aluminum hydroxide and magnesium hydroxide suspension in a dose ratio of 0.5-5mg to 1ml. The invention further discloses a method for preparing the composition for treating oral mucositis. The method comprises the following steps: 1, preparing the suspension from hydroxyethyl cellulose, hydroxy propyl cellulose, simethicone, aluminum hydroxide and magnesium hydroxide; 2, adding sorbitol, mannitol and butyl p-hydroxybenzoate to regulate the pH value to obtain the aluminum hydroxide and magnesium hydroxide suspension; and 3, adding ropivacaine mesylate into the aluminum hydroxide and magnesium hydroxide suspension, and uniformly stirring to obtain the suspension for treating oral mucositis. The invention further discloses an application package for the composition for treating oral mucositis. The composition for treating oral mucositis has the advantages of relieving pain and diminishing inflammation, repairing the mucosa ulcer face and the like, and is convenient to use.

Description

technical field [0001] The invention relates to a composition for treating mucositis, a preparation method and application packaging thereof, in particular to a composition for treating oral mucositis, a preparation method and application packaging thereof, and belongs to the technical field of medicine. [0002] Background technique [0003] The incidence of cancer has risen rapidly in recent decades, and it has become the number one killer affecting human health. At present, the main means of treating cancer are chemotherapy and radiotherapy. Oral mucositis is a common potential serious complication of cancer patients receiving radiotherapy, mainly manifested as mucosal erythema, edema, peeling, ulceration, bleeding and (or) exudation, leading to oral pain, eating disorders, and secondary Increased risk of infection. The occurrence of oral mucositis will disrupt the anticipation of radiotherapy in cancer patients, significantly affecting the lives of patients and the co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/08A61K9/10A61P1/02A61P29/00A61K31/445
Inventor 何雪心戴小兰左克源傅苗青
Owner 左克源
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