The invention relates to the technical field of medical PVC granules, and discloses an environment-friendly matte medical PVC granule and a preparation method thereof. The preparation method comprises the following steps of S1, enabling PVC cross-linked resin and other auxiliary additives to be subjected to mass weighing, S2, adding the materials into a high-speed mixer for mixing and stirring, S3, adding gas-phase nano silicon dioxide into the hot mixed powder, S4, stirring the hot mixed powder at a constant speed, and cooling the hot mixed powder in a cold mixer, S5, after the temperature of the mixture is cooled, adding the cooled mixed powder into an extruder for granulation, S6, adjusting the temperature of a machine barrel to be 150 DEG C and the temperature of a die head to be 155 DEG C, and carrying out pelletizing, and S7, cooling after pelletizing, and finally packaging and warehousing. According to the environment-friendly matte medical PVC granule and the preparation method thereof, the formula is reasonable, the production process is advanced, the matte requirement of the appearance of a medical instrument can be met, and the environment-friendly performance is high.