The invention discloses a production technology of a medical fabric. The technology comprises the following steps of grey fabric weaving, desizing, drying, splashing and sizing, calendering treatment, and coating of a double-sided coating, wherein the calendered surface of the fabric is coated with a PU resin coating with water pressure resistance; the PU resin coating is divided into a PU polyether two-component base material and a PU one-component fabric for separate coating; after the calendered surface is coated, the fabric is dried through high-temperature oven until being rolled up, and the other side of the fabric is coated with an organic silicone coating, and high-temperature drying is carried out to obtain the medical fabric. The tissue style characteristics of the woven fabric are integrated, and coating finishing is carried out on the front and reverse sides of the fabric, so that the fabric has the characteristics of being waterproof, easy to decontaminate and high in tenacity, and the production technology is suitable for the medical fabric.