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Controlled drug-release magnesium or magnesium alloy bionic bone and preparation method thereof

A magnesium alloy, bionic bone technology, applied in the field of biomedical materials, can solve the problems of affecting the performance, easy formation of oxides or inclusions, complex preparation process, etc., to increase the success rate, improve the quality of life, and alleviate the effects of degradation.

Active Publication Date: 2020-07-14
JIAMUSI UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the preparation process of porous magnesium or magnesium alloy materials, due to the active chemical properties of magnesium, it is easy to oxidize, avoid corrosion and intense combustion, so it is necessary to add a reducing agent for reduction during the preparation process, and it needs to be carried out in a vacuum environment and a reduction furnace. , leading to complex preparation process; moreover, a large number of foaming agents and pore-forming agents are introduced in the process of preparing porous magnesium or magnesium alloy materials, so oxides or inclusions are easily formed in porous magnesium materials, which affects its performance , which limits its application

Method used

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  • Controlled drug-release magnesium or magnesium alloy bionic bone and preparation method thereof
  • Controlled drug-release magnesium or magnesium alloy bionic bone and preparation method thereof
  • Controlled drug-release magnesium or magnesium alloy bionic bone and preparation method thereof

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preparation example Construction

[0033] The invention provides a method for preparing magnesium or magnesium alloy bionic bone with controlled drug release, comprising the following steps:

[0034] According to the predetermined bone structure parameters, pulse laser processing is performed on magnesium or magnesium alloy to obtain porous magnesium or magnesium alloy;

[0035] performing micro-arc oxidation treatment and alkali treatment on the porous magnesium or magnesium alloy in sequence to obtain modified porous magnesium or magnesium alloy;

[0036] Soak the modified porous magnesium or magnesium alloy in the Chinese medicine slow-release solution, take it out and dry it to obtain the controlled drug release magnesium or magnesium alloy bionic bone;

[0037] The traditional Chinese medicine sustained-release liquid includes naringin, polylactic acid-glycolic acid copolymer and an organic solvent; the organic solvent includes methylene chloride, chloroform, petroleum ether or ethyl acetate.

[0038] In ...

Embodiment 1

[0068] Design the pore size data of porous magnesium or magnesium alloy according to the structural parameters of the lower jaw of the rabbit (the porosity is 70%, and the pore size is 500 μm and 1000 μm respectively, such as figure 1 As shown), according to the finite element software, the geometric model and processing track of porous magnesium or magnesium alloy are established, and pulse laser processing is performed to obtain porous magnesium or magnesium alloy; wherein, the working parameters of the pulse laser processing include: a wavelength of 1064nm solid laser, laser spot The output energy is 10J, the output power is 60W, the output voltage is 800V, the pulse width is 1ms, the frequency is 10Hz, and the water temperature is 25°C.

[0069] Use water sandpaper to polish the porous magnesium or magnesium alloy until the surface is smooth, soak in ethanol for 2min, rinse with distilled water, place in 8g / mL NaHCO 3 In the solution for 10s, rinse with tap water, rinse ...

Embodiment 2

[0073] Prepare controlled drug release magnesium or magnesium alloy biomimetic bone according to the method of Example 1. The difference from Example 1 is that the pore diameter data of porous magnesium or magnesium alloy is: the porosity is 65%, and the pore diameters are 300 μm, 500 μm and 300 μm respectively. 1000μm, such as figure 2 shown;

[0074] The working parameters of pulsed laser processing include: solid-state laser with a wavelength of 1064nm, laser spot The output energy is 300μm, the output energy is 7J, the output power is 55W, the output voltage is 600V, the pulse width is 1.5ms, the frequency is 10Hz, and the water temperature is 25°C.

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Abstract

The invention provides a controlled drug-release magnesium or magnesium alloy bionic bone and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparationmethod includes the following steps: performing pulsed laser processing on magnesium or magnesium alloy according to predetermined bone structure parameters so as to obtain porous magnesium or magnesium alloy; successively performing micro-arc oxidation treatment and alkali treatment on the porous magnesium or magnesium alloy so as to obtain modified porous magnesium or magnesium alloy; and soaking the modified porous magnesium or magnesium alloy into a traditional Chinese medicine sustained release solution, and taking the modified porous magnesium or magnesium alloy out to dry so as to obtain the controlled drug-release magnesium or magnesium alloy bionic bone, wherein the traditional Chinese medicine sustained release solution includes naringin, PLGA and a volatile solvent of soluble poly(lactic-co-glycolic acid). The preparation method is simple in technology; the adding of foaming agents or pore forming agents is not needed; and the prepared controlled drug-release magnesium or magnesium alloy bionic bone is excellent in using performance.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a controlled drug release magnesium or magnesium alloy bionic bone and a preparation method thereof. Background technique [0002] Trauma bone repair materials have become one of the current research hotspots in the field of orthopedics. They can be used as surgical implant materials for human hard tissue repair or replacement, and have a wide range of clinical application requirements. Magnesium and magnesium alloys have good osteoinductivity, degradability, biocompatibility and other characteristics, especially in the repair and replacement materials of hard tissues such as bones, teeth and joints, and have broad application prospects and application values. [0003] In the preparation process of porous magnesium or magnesium alloy materials, due to the active chemical properties of magnesium, it is easy to oxidize, avoid corrosion and intense combustion, so it is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/30A61L27/28A61L27/34A61L27/50A61L27/54A61L27/56A61L27/58C25D11/30C23F1/40B23K26/382
CPCA61L27/047A61L27/28A61L27/306A61L27/34A61L27/50A61L27/54A61L27/56A61L27/58A61L2300/216A61L2300/404A61L2300/412A61L2300/602A61L2300/606A61L2400/18A61L2420/02A61L2420/06A61L2420/08A61L2430/02B23K26/382B23K2103/15C23F1/40C25D11/026C25D11/30C08L67/04
Inventor 牟立婷李慕勤马振王晶彦熊鑫刘威于艳霞
Owner JIAMUSI UNIVERSITY
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