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An adsorbent for removing beta-2 microglobulin from blood

A technology of BETA-2 and microglobulin, which is applied in the field of adsorbents for removing BETA-2 microglobulin in blood, can solve the problems of poor adsorption selectivity of BETA-2 microglobulin, and achieve excellent adsorption performance

Active Publication Date: 2016-07-06
TIANJIN YOUNASI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no such product on the market in my country
There is a patent to prepare a large-pore adsorbent by grafting basic ligands on cellulose and other ligands. The molecular permeability range of the adsorbent is 11,000-5,100,000 Daltons, and the adsorption selectivity for BETA-2 microglobulin is relatively high. Difference

Method used

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  • An adsorbent for removing beta-2 microglobulin from blood

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Embodiment 1

[0021] The preparation of embodiment 1 highly cross-linked macroporous microspheres

[0022] At room temperature, dissolve 10g of gelatin in 1000ml of water to make a 1.0% (mass fraction) aqueous solution, place it in a 2000ml three-necked flask and heat it to 45°C to fully dissolve the gelatin; mix 50g of styrene, 100g of divinylbenzene , 0.3g polylysine, 99.7g toluene, 200g gasoline (No. 200 gasoline) and 1.5g azobisisobutyrocyanide were mixed evenly, then added to the three-necked bottle, started to stir, and adjusted the speed to disperse the oil droplets, and after suspension Polymerization, slowly heat up to 78°C at a speed of 1-2°C / 5 minutes, react for 3 hours, then slowly heat up to 85°C at a speed of 1-2°C / 5 minutes, react for 3 hours, and then heat up at a speed of 1-2°C / 5 minutes Slowly raise the temperature to above 95°C at a speed of 5 minutes, react for 5 hours, then stop the reaction, filter and wash, and prepare cross-linked polystyrene-divinylbenzene macroporo...

Embodiment 2

[0023] The preparation of embodiment 2 highly cross-linked macroporous microspheres

[0024] At room temperature, dissolve 12g of polyvinyl alcohol in 1200ml of water to make a 1.0% (mass fraction) aqueous solution, place it in a 3000ml three-neck bottle and heat it to 45°C to fully dissolve the polyvinyl alcohol; add 25g of styrene, 125g Divinylbenzene, 1.0g polylysine, 99g toluene, 25g liquid paraffin, 25g solid paraffin and 2.0g benzoyl peroxide were evenly mixed and then added to the three-necked bottle, started to stir, and adjusted the speed to disperse the oil beads, and suspended Polymerization, slowly heat up to 78°C at a speed of 1-2°C / 5 minutes, react for 3 hours, then slowly heat up to 85°C at a speed of 1-2°C / 5 minutes, react for 3 hours, and then heat up at a speed of 1-2°C / 5 minutes Slowly raise the temperature to above 95°C at a speed of 5 minutes, react for 5 hours, then stop the reaction, filter and wash, and prepare highly cross-linked polystyrene-divinylben...

Embodiment 3

[0025] The preparation of embodiment 3 highly cross-linked macroporous microspheres

[0026] At room temperature, dissolve 10g of polyvinyl alcohol in 1000ml of water to make a 1.5% (mass fraction) aqueous solution, place it in a 2000ml three-necked bottle and heat it to 45°C to fully dissolve the polyvinyl alcohol; dissolve 150g of divinylbenzene , 1.5g polylysine, 198.5g toluene, 125g liquid paraffin, 125g solid paraffin and 2.0g benzoyl peroxide were mixed evenly and then added to the three-necked bottle, started to stir, and adjusted the speed to disperse the oil beads. After suspension polymerization, the Slowly heat up to 78°C at a speed of 1-2°C / 5 minutes, react for 3 hours, then slowly heat up to 85°C at a speed of 1-2°C / 5 minutes, react for 3 hours, and then heat up at a speed of 1-2°C / 5 minutes Slowly raise the temperature to above 95°C, react for 5 hours, then stop the reaction, filter and wash to prepare highly cross-linked polystyrene-divinylbenzene macroporous mi...

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Abstract

The invention relates to an adsorbent for removing BETA-2 microglobulin in blood. The polystyrene type adsorbent with certain aperture and high specific surface area is designed according to the molecular dimensions of albumin and BETA-2 microglobulin; the adsorbent is capable of selectively removing medium molecular substances (such as the BETA-2 microglobulin) instead of macromolecular protein. Furthermore, the adsorbent has the characteristics of being simple in preparation technology, good in biocompatibility, large in adsorption capacity, free from risk of electrolyte disturbance and the like, thus being used for plasma perfusion and used for removing medium molecular toxin in the blood by all-blood perfusion.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a novel medical adsorbent, in particular to an adsorbent suitable for removing BETA-2 microglobulin in blood through in vitro blood perfusion. Background technique [0002] BETA-2 microglobulin is a small molecular globulin with a molecular weight of 11800 and a single-chain polypeptide composed of 99 amino acids. It is the β-chain part of the human lymphocyte antigen (HLA) on the cell surface. Produced by polymorphonuclear leukocytes, most of the BETA-2 microglobulin in normal human body is absorbed or eliminated by the proximal renal tubule. In patients with chronic renal failure and chronic dialysis, the concentration is abnormally increased. The concentration of BETA-2 microglobulin in the blood of patients with renal dysfunction can be 40-60 times higher than the normal level. The accumulation of BETA-2 microglobulin is a key factor in inducing postdialysis amylopathy (DR...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/14
Inventor 欧来良俞耀庭王为超
Owner TIANJIN YOUNASI BIOTECH
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