Percutaneous absorption preparation

A technology for transdermal absorption preparations and pharmaceutical preparations, applied in the field of external TDS preparations, which can solve the problems of inconvenient use and poor targeting of tobramycin

Active Publication Date: 2014-12-17
嘉善县魏塘资产管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the disadvantages of inconvenient use and poor targeting of existing tobramycin, the present invention invented a tobramycin skeleton transdermal absorption preparation

Method used

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  • Percutaneous absorption preparation

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Embodiment 1

[0018] It includes four parts: storage layer, adhesive layer, backing layer and protective layer, wherein the drug storage layer of the storage layer includes two layers of drug storage layer 1 and drug storage layer 2, and the composition of drug storage layer 1 is tobramycin 6g, polyvinyl chloride 52g, serine 0.5g, N-ethylpyrrolidone 2g, sodium lauryl sulfate 4g; the composition of the drug reservoir layer 2 is tobramycin 6g, pressure-sensitive adhesive 1g, serine 0.5g, N-ethyl 2 g of pyrrolidone, 2 g of sodium lauryl sulfate; the adhesive layer includes 3 g of pressure-sensitive adhesive. The other ingredient of this embodiment is water. Preferably, 1 "g" above represents 1 gram.

[0019] The preparation method is as follows: after dissolving the drug tobramycin in the drug storehouse layer 1 with water, mix it evenly with polyvinyl chloride, serine, N-ethylpyrrolidone and sodium lauryl sulfate, and place it on a clean, flat and smooth glass plate , make into a thin film,...

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Abstract

The invention relates to an externally-applied TDS preparation and in particular relates to a frame type percutaneous absorption preparation with tobramycin as an active component and a preparation process of the frame type percutaneous absorption preparation. According to the frame type percutaneous absorption preparation, a composition of serine, N-ethyl pyrrolidone and sodium laurylsulfate is used as a penetration enhancer, and the weight proportion of the serine to the N-ethyl pyrrolidone to the sodium laurylsulfate is 1:4:6.

Description

technical field [0001] The application relates to an external TDS preparation, specifically, a skeleton-type transdermal absorption preparation with tobramycin as an active ingredient and a preparation process thereof. Background technique [0002] Tobramycin is an aminoglycoside drug that is actively transported through the bacterial cell membrane, binds to the special receptor protein of the bacterial ribosome 30S subunit, interferes with the formation of the initial complex between the information ribonucleic acid and the 30S subunit, and inhibits Protein synthesis; cause DNA misreading, resulting in the synthesis of non-functional proteins; cause polyribosomes to split and lose the function of synthesizing proteins. It is clinically used for local infection of the outer eye and adnexa caused by sensitive bacteria. Compared with other aminoglycoside antibiotics, it has a wider antibacterial spectrum, higher curative effect and less toxic reaction. Gram-positive Staphylo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/702A61K47/22A61P31/04
Inventor 黄祥彬李志征周祎谢姗瑾
Owner 嘉善县魏塘资产管理有限公司
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