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Yeast powder for reducing and stabilizing blood sugar as well as preparation method and application of yeast powder

A technology of yeast and Pichia pastoris, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and plant/algae/fungus/moss ingredients, etc. To achieve the effect of easy mass production, lower blood sugar, and high safety

Inactive Publication Date: 2015-01-07
XIAN GUOYU BIOTECH
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  • Abstract
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Problems solved by technology

However, the side effects of the drug include gastrointestinal reactions; and the dosage is not easy to control, and hypoglycemia reactions are prone to occur after taking it, and glucose will be administered orally or intravenously

Method used

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  • Yeast powder for reducing and stabilizing blood sugar as well as preparation method and application of yeast powder
  • Yeast powder for reducing and stabilizing blood sugar as well as preparation method and application of yeast powder
  • Yeast powder for reducing and stabilizing blood sugar as well as preparation method and application of yeast powder

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Embodiment Construction

[0045] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0046] In order to overcome the single action mechanism of current diabetes drugs, the present invention considers all aspects of pancreatic islet cell repair, insulin-stimulated release, insulin sensitization, and direct action of insulin, and utilizes genetic technology to construct yeast expressing recombinant GLP-1 analogues, and In order to solve the shortcoming that natural GLP-1 is easily degraded by dipeptidyl peptidase Ⅳ (DPP-Ⅳ) in the body, and its plasma half-life is less than 2 minutes, the recognition site for DPP-Ⅳ to degrade GLP-1 is at the second amino acid A, change it to G, which is not recognized by enzymes, to prolong the half-life without affecting biological activity. The yeast is expressed with the recombinant gene, and the inorganic chromium, inorganic selenium and ino...

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Abstract

The invention discloses yeast powder for reducing and stabilizing blood sugar as well as a preparation method and application of the yeast powder. The yeast is expressed as GLP-1, and contains a glucose tolerance factor, selenium yeast and vanadium yeast converted by inorganic chromium, inorganic selenium and inorganic vanadium. According to the yeast powder disclosed by the invention, islet cells are promoted to secrete insulin through glucagon-like peptide-1; through the glucose tolerance factor, insulin resistance is reduced and insulin sensitivity is enhanced; and through the organic selenium yeast, repairing of the islet cells is promoted. From islet cell repairing and insulin releasing to insulin sensitizing, the organic vanadium directly serves as para-insulin and comprehensively treats pathogen of type II diabetes, and an effect is much better than that of a single treatment scheme; moreover, multiple efficacy factors are prepared through single yeast powder production; the yeast powder is easy for mass production, low in cost, and more economical and applicable.

Description

technical field [0001] The invention belongs to the technical field of diabetes prevention and treatment, and relates to a sugar-lowering and sugar-stabilizing yeast powder and a preparation method and application thereof. Background technique [0002] Diabetes has been listed as the third biggest killer after cardiovascular and cerebrovascular diseases and tumors. With changes in lifestyle and diet, the global prevalence of diabetes is on the rise. It is estimated that by 2030, the number of people with diabetes in the world will increase to 366 million, and diabetes will become a heavy burden for many families and society. [0003] The etiology of type II diabetes patients is multifaceted. Some patients are due to insufficient insulin secretion, but some diabetics not only do not lack insulin in their bodies but are higher than normal. The cause is insensitivity to insulin (insulin resistance). The vast majority of people with type 2 diabetes will inevitably be treated w...

Claims

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Application Information

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IPC IPC(8): A61K36/064A61P3/10A61K33/04A61K33/24
CPCA61K33/04A61K33/24A61K36/064A61K2236/19A61K2300/00
Inventor 李元师长宏赵金礼张明杰
Owner XIAN GUOYU BIOTECH
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