The invention discloses a preparation method of a compound food base material enriched with blood glucose reducing factors. The preparation method of the compound food base material enriched with the blood glucose reducing factors comprises the following steps: a), taking 
oat bran, adding 
distilled water into the 
oat bran, adding saccharifying enzymes so as to carry out 
enzymatic hydrolysis, and carrying out sterilization so as to obtain a saccharified oat-
bran solution; b), inoculating 
saccharomyces cerevisiae into the saccharified oat-
bran solution, and simultaneously adding inorganic chrome so as to carry out 
fermentation, so that compound chrome-enriched oat-
bran yeast liquid is obtained; c), putting dried 
mulberry leaf power into an extraction tank, adding a 0.05 mol / l 
hydrochloric acid-
ethanol solution, carrying out extraction at 30-50 DEG C for 60-150 minutes, carrying out 
centrifugation for 10-20min and obtaining the supernatant, extracting the residues by repeating the steps for 1-2 times, and combining the supernatant, so that a deoxynojirimycin-enriched 
mulberry leaf extract is obtained; and d), mixing the compound chrome-enriched oat-bran 
yeast liquid with the deoxynojirimycin-enriched 
mulberry leaf extract, concentrating the mixture, and carrying out 
drying, so that the compound food base material enriched with blood glucose reducing factors is prepared. The preparation method is basically performed in the presence of low temperature, so that changes of the three natural active ingredients, namely the deoxynojirimycin, the oat beta-
dextran and the glucose tolerance factors, can be effectively avoided so as to ensure the nutritional qualities of the compound food base material enriched with the blood glucose reducing factors.