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Compositions for senile diabetes patient blood sugar and blood fat reduction

A blood sugar, human body technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, metabolic diseases, etc., can solve the problem of unsolved type II diabetes, and achieve the effect of conforming to the physiological state of the human body, increasing sensitivity, and reducing insulin resistance.

Inactive Publication Date: 2004-12-29
高春平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both of the above two patents only use a single trivalent chromium supplement, which does not solve the most important cause of type II diabetes, that is, insulin resistance caused by obesity after aging, which in turn leads to hyperglycemia and hyperlipidemia.

Method used

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Examples

Experimental program
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preparation example Construction

[0049] Preparation method of the composition:

[0050] In the present invention, the above-mentioned various free amino acids can be purchased from a number of biopharmaceutical companies, or can be prepared by hydrolyzing protein with proteinase from high-quality proteins such as casein white and soybean protein by using the method of protein hydrolysis. The preparation methods are known methods.

[0051] The synthetic method of chromium trippicolinate is disclosed in U.S. Patent (US5,087,623). Chromium trippicolinate can be purchased as a commercial product in many pharmaceutical companies.

[0052] For oral administration, various free amino acids and tripicolinic acid in the above embodiments can be provided in the form of tablets, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules, syrups or elixirs. Compositions for oral administration may be prepared by any of the methods known in the art for the manufacture of pharmaceutical...

Embodiment

[0064] The composite capsule prepared from the composition of the invention is used for clinical trials. Carry out randomized double-blind clinical experiment to 20 type II diabetics, 1 / 2 patient takes orally the compound capsule of composition of the present invention every day, contains 1000mg arginine, 1000mg lysine, 250mg L-glutamine in daily dosage, 500μg chromium tripicolinate (take 5 compound capsules every day, each capsule contains 200mg arginine, 200mg lysine, 50mg glutamine, 100μg chromium tripicolinate). Another 1 / 2 takes placebo, takes 6 months by above-mentioned dosage, measures glycated hemoglobin (HBA1C) and weighing respectively when this experiment begins and ends, after this experiment finishes, the patient who takes composition of the present invention, glycosylation Hemoglobin decreased by an average of 15% and body weight decreased by 8%. In contrast, the changes in these parameters were not statistically significant in patients taking daily placebo.

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Abstract

The present invention is method of replenishing essential nutritive components to lower body's blood fat and blood sugar. Free amino acids and chromium picolinate are provided to replenish amino acids and trivalent chromium, and this can irritate the release of body's growth hormone, strengthen muscle, reduce fat, improve blood fat metabolism, strengthen glucose tolerance factor effect, reduce insulin resistance, lower blood sugar and improve blood sugar metabolism. The said method is suitable for obese senile people to prevent and treat type-II diabetes and metabolism syndrome.

Description

Technical field: [0001] The invention relates to the treatment of senile obesity and non-insulin dependent (type II) diabetes. More particularly, the present invention relates to the treatment of type II diabetic patients by administering complex amino acids and chromium tripicolinate. Background technique: [0002] Diabetes is a chronic metabolic disease. There are about 130 million patients in the world, and about 50 million patients in China. In addition, many people have not yet been diagnosed. Many non-insulin-dependent diabetes mellitus (or type II diabetes) occurs in elderly and obese people. The main feature is that insulin resistance is caused by obesity and lack of exercise, and blood sugar cannot be effectively used to cause hyperglycemia, which then stimulates islet β cells to release more insulin to make up for the lack of hypoglycemic ability of a unit amount of insulin, and eventually leads to pancreatic β cells The function is impaired, the compensatory abi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61K31/40A61P3/06A61P3/10
Inventor 高春平
Owner 高春平
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