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Method for preparing niacin-glutathione-trivalent chromium ion chelate

A glutathione and chelate technology, which is applied in the field of bioorganic chromium preparation, can solve the problems of low biological activity and large component differences, and achieve the effects of high product quality, high added value, and low energy consumption

Inactive Publication Date: 2016-02-24
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of this method is: as an analog of glucose tolerance factor, the chromium nicotinate chelate product prepared by this method only contains nicotinic acid ligand, and does not contain glutamic acid, glycine, cysteine ​​or short peptides, etc. Ligand, which has a large difference in composition from glucose tolerance factor and low biological activity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A method for preparing niacin-glutathione-trivalent chromium ion chelate, the specific steps are as follows.

[0021] (1) Preparation of niacin-glutathione aqueous solution

[0022] Using niacin and glutathione as raw materials, according to the ratio of the amount of niacin (mol): the amount of glutathione (mol): the volume (L) of purified water is 1: 4: 30 Ratio, in purified water at 55°C, add niacin and glutathione while stirring until dissolved, and prepare a niacin-glutathione aqueous solution with a concentration of niacin and glutathione of 1mol / L.

[0023] (2) Preparation of Niacin-Glutathione-Cr 3+ Chelate solution

[0024] After the (1) step was completed, the ratio of the volume (L) of the nicotinic acid-glutathione aqueous solution prepared according to the amount of chromium trichloride (mol): (1) step was 1: 100 ratio, Add chromium trichloride to the nicotinic acid-glutathione aqueous solution prepared in step (1) and stir until dissolved to obtain nico...

Embodiment 2

[0028] A method for preparing nicotinic acid-glutathione-trivalent chromium ion chelate, same as embodiment 1, wherein:

[0029] In the (1) step, the amount of substance (mol) of niacin: the amount of substance (mol) of glutathione: the ratio of the volume (L) of pure water is 1: 1.5: 20, and the temperature of pure water is 60 °C, the concentration of niacin and glutathione in the prepared niacin-glutathione aqueous solution is 2mol / L.

[0030] In the (2) step, the amount of substance (mol) of chromium trichloride: the ratio of the volume (L) of the nicotinic acid-glutathione aqueous solution prepared in the (1) step is 1: 130, and the pH value of the aqueous solution is 4.86, the temperature is 60°C, and the chelation reaction time is 6h.

[0031]In the (3) step, the vacuum degree of carrying out vacuum concentration is 0.08MPa, and temperature is 60 ℃, and the volume of concentrated solution is until 1 / 4 of former chelate solution volume, the volume (L) of vacuum concentra...

Embodiment 3

[0033] A method for preparing nicotinic acid-glutathione-trivalent chromium ion chelate, same as embodiment 1, wherein:

[0034] In the (1) step, the amount of substance (mol) of niacin: the amount of substance (mol) of glutathione: the ratio of the volume (L) of pure water is 1: 0.25: 10, and the temperature of pure water is 65 °C, the concentration of niacin and glutathione in the prepared niacin-glutathione aqueous solution is 3mol / L.

[0035] In the (2) step, the amount of substance (mol) of chromium trichloride: the ratio of the volume (L) of the nicotinic acid-glutathione aqueous solution prepared in the (1) step is 1: 160, and the pH value of the aqueous solution is 6.86, the temperature is 65°C, and the chelation reaction time is 8h.

[0036] In the (3) step, the vacuum degree of carrying out vacuum concentration is 0.09MPa, and temperature is 65 ℃, and the volume of concentrated solution is until 1 / 5 of former chelate solution volume, the volume (L) of vacuum concent...

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Abstract

The invention relates to a method for preparing a niacin-glutathione-trivalent chromium ion chelate and particularly relates to a preparation method of a biologic organic chromium chelate. According to the method, the niacin-glutathione-trivalent chromium ion chelate is prepared by utilizing following simple processes of with niacin, glutathione and chromium trichloride as raw materials, preparing a niacin-glutathione water solution, preparing a niacin-glutathione-Cr<3+> chelate solution, and preparing niacin-glutathione-Cr<3+> chelate freeze-dried powder. The niacin-glutathione-trivalent chromium ion chelate prepared by utilizing the method does not contain Cl<-1>, the content of Cr<3+> reaches 8.95-14.63%, and is very similar to a natural glucose tolerance factor, the purity is high, and the method has the characteristics of mild condition, simple operation step, high comprehensive resource utilization rate, environmental friendliness, pollution free and the like. The niacin-glutathione-trivalent chromium ion chelate prepared by utilizing the method can be taken as a medicament and a nutrient to be widely applied to the fields of medicines, health products, feed additives and the like and can be used for improving the glycometabolism of diabetics, improving the meat quality of livestock, and the like.

Description

1. Technical field [0001] The invention belongs to the technical field of bioorganic chromium preparation, and in particular relates to a preparation method of bioorganic chromium chelates. 2. Background technology [0002] Glucose tolerance factor (GTF) is an organic chromium chelate with niacin, glutamic acid, glycine, cysteine ​​or short peptide as ligands, in which trivalent chromium ion (Cr 3+ ) is its active center and the basis of organic chromium's biological activity. Glucose tolerance factor, that is, organic chromium chelate has the functions of enhancing insulin activity, regulating metabolism, promoting animal growth, improving immunity, improving reproductive performance, and improving ketone body quality. Therefore, organic chromium chelates are widely used in medicine, health care products, feed additives and other fields as medicines and nutrients, and can improve glucose metabolism of diabetic patients and improve meat quality of poultry and livestock. ...

Claims

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Application Information

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IPC IPC(8): C07K5/037C07K1/107
Inventor 周桢颜李秀周小华王尊贤万玉萍冯琳
Owner CHONGQING UNIV
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