The invention discloses an efficient cultivation method of greenhouse muskmelons. The cultivation method comprises the following steps of 1, seedling raising, namely, 1, seedling raising time, 2, seedsoaking and germination accelerating, 3, sowing, and 4, seedbed management; 2, preparation before cultivation, namely, 1, rice husk pavement on the ground, 2, cultivation bed setting out, 3, cake fertilizer application, 4, edible fungus leftover applying, 5, cultivation groove manufacturing, and 6, commercial organic fertilizer application; 3, planting cultivation, namely, muskmelon seedling planting; 4, field management, namely 1, hose drip tube belt placement, 2, mulching film laying, 3, muskmelon seedling vine hanging, 4, pruning, 5, artificial pollination, 6, honeybee pollination, 7, muskmelon pre-flowering management, 8, muskmelon hanging, 9, water and fertilizer management, and 10, pest control; and 5, harvesting. The cultivation method is scientific and reasonable, damage of diseases and insect pests to the muskmelons can be reduced, soil is improved, the yield of the muskmelons is increased, economic benefits are increased, and the cultivation method has good market prospects.