Biodegradable lutein microspheres and manufacturing method thereof

A biodegradable and lutein technology, used in the fields of medicine, beverage and food, can solve the problems of limited solubility and high sensitivity, hinder the direct use of crude products, poor dyeing effect, etc., to improve the slow and controlled release treatment effect, improve Gastrointestinal side effects, improvement of physical properties

Inactive Publication Date: 2015-02-11
天津新济复兴药业科技有限公司
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Limited solubility and high sensitivity to oxidation prevent the direct use of the synthetically obtained crude product in food and feed dyeing, since only poor absorption and poorer dyeing results are obtained in the crude crystalline form of the substance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Biodegradable lutein microspheres and manufacturing method thereof
  • Biodegradable lutein microspheres and manufacturing method thereof
  • Biodegradable lutein microspheres and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0026] Different organic solvents of example 1 are used to prepare lutein PLGA microspheres

[0027] In this example, dimethyl carbonate (DMC), dichloromethane (DCM), and ethyl acetate (Et-Ac) were selected as organic solvents to prepare three groups of microsphere preparations. The formulations of the three groups of microsphere preparations are shown in Table 1. The formula of each microsphere preparation is 10wt% lutein and 90wt% polyester.

[0028] The type of solvent has a significant impact on the morphology of the product. In this example, lutein PLGA microspheres were prepared through different organic solvents. The preparation method using UPPS system is as follows:

[0029] (1) Weigh 0.1g lutein (1) and 0.9g ester-terminal PLGA (molecular weight is 40,000, LA / GA=50 / 50) in proportion;

[0030] (2) Put the PLGA (molecular weight is 40,000, LA / GA=50 / 50) at the end of the ester group in the step (1) into an organic solvent to completely dissolve to obtain a clear orga...

example 2

[0036] The preparation of the lutein microspheres of the PLGA of the different types of ester group end of example 2

[0037] This example prepares group 1: the lutein microsphere preparation of PLGA (molecular weight is 40,000, LA / GA=50 / 50) of ester group end, group 2: the PLGA of ester group end (molecular weight is 45,000, LA / GA=75 / 25 ) lutein microsphere preparation, the organic solvent used in this embodiment is a mixed solution of dichloromethane (DCM) and dimethyl carbonate (DMC), wherein the lutein microsphere formulation of group 1 is 32wt% lutein and 68wt% polyester Class, specifically PLGA (molecular weight is 40,000, LA / GA=50 / 50) of 0.45g lutein and 0.97g ester group terminal, and its preparation method is:

[0038] (1) Weigh 0.45g lutein and 0.97g ester-terminal PLGA (molecular weight is 40,000, LA / GA=50 / 50) in proportion;

[0039] (2) Put the PLGA (molecular weight is 40,000, LA / GA=50 / 50) in step (1) into dichloromethane (DCM) and dimethyl carbonate (volume rati...

example 3

[0049] Mix 50g of lutein (content: 70% ± 5%) and 25g of microporous starch at room temperature, add 35g of maltodextrin, 6g of CMC-Na (carboxymethyl cellulose), 5g of sucrose, 0.1g of TBHQ, silk Mix the aqueous solution of 15g of plain protein colloid and stir evenly. The solution is supplied to the high-speed rotating disc of the droplet generating device through the peristaltic pump through the nozzle at an even speed. Micro-droplets are formed, the micro-droplets are in contact with the gas molecules in the gas field, the solvent volatilizes, the liquid-gas interface on the surface of the micro-droplets first solidifies, and then the internal solvent molecules gradually diffuse outward, and the polymer polymers precipitate inward until the micro-droplets are completely solidified The microspheres are obtained and the solidified microspheres settle and are collected in a sample collector or via a cyclone. Microspheres with an average particle size of 90 μm and a lutein conte...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
molecular weightaaaaaaaaaa
viscosityaaaaaaaaaa
Login to view more

Abstract

The invention provides a manufacturing method for preparing biodegradable lutein microspheres through applying an ultrafine particle preparation system (UPPS). The manufacturing method comprises the steps: dissolving an insoluble drug lutein in an organic solvent, mixing with an easily-soluble biodegradable carrier material, treating by a UPPS device to form micro-droplets, solidifying the micro-droplets, and thus forming the lutein microspheres. The method can be used for continuous large-scale production, the lutein loading amount is 1-30%, the particle size distribution is uniform, and the entrapment rate reaches 95% or more. The lutein microspheres prepared by the method can reach the purpose of sustained release, increases the stability and water solubility of the lutein, and is convenient for transportation and preservation of lutein.

Description

technical field [0001] The invention belongs to the technical fields of medicine, food, beverage and the like, in particular, the invention relates to a lutein microsphere and a preparation method thereof. Background technique [0002] Lutein is a carotenoid, a natural pigment, with bright color, strong tinting power, good anti-oxidation, safe and non-toxic, and rich in nutritional value. It is a natural substance that widely exists in vegetables, flowers, fruits and some algae plants, and is widely used in many fields such as food, health care products, cosmetics, medicine, tobacco and animal and poultry feed. The U.S. Food and Drug Administration has approved lutein as a food supplement for use in food as early as 1995. Due to the wide application of lutein, in the international market, 1g of lutein is equivalent to 1g of gold, so it has the reputation of "plant gold". [0003] The results of the latest research show that lutein can protect vision. In addition, it also h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/047A61P27/12A61P9/10A61P37/04A61P35/00
Inventor 崔景柏吴传斌梁华辉张乃军
Owner 天津新济复兴药业科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap